Liver function parameters in patients with external genital endometriosis and infertility
Gerasimov A.M., Malyshkina D.A., Malyshkina A.I.
Relevance: Inflammation is a key factor in the pathogenesis of endometriosis. To reduce secondary autoaggression, the body utilizes several detoxification systems, the most important of which are the urinary system, the macrophage-macrocytic system, and the liver. Liver function parameters in endometriosis have been understudied.
Objective: To assess liver function based on biochemical blood tests in patients with external genital endometriosis and infertility.
Materials and methods: The study included the patients who were admitted to hospital for therapeutic and diagnostic laparoscopy to determine the causes of infertility. Among them were women with external genital endometriosis (n=36) and the signs of chronic salpingitis (n=36). All patients underwent blood tests for creatinine, total bilirubin, urea, glucose, total protein, ALT, AST, as well as measurements of the liver frailty index (LFI) and De-Ritis ratio (DRR).
Results: Analysis of the relationship between the liver function test results and the stages of endometriosis showed a moderately negative correlation for the DRR (r=-0.49; p<0.05). The LFI values were not associated with the degrees of endometriosis (r=0.23; p>0.05).
Conclusion: Our study demonstrated changes in liver function with the development of endometriosis. Based on the obtained data it is prudent to recommend a comprehensive evaluation of hepatobiliary function in patients with external genital endometriosis, that will enable a multidisciplinary approach and subsequently, a rationale for expanding drug therapy options for these patients.
Authors' contributions: Gerasimov A.M. – the study concept and design, statistical data processing; Malyshkina D.A. – material collection and processing; Gerasimov A.M., Malyshkina D.A. – manuscript writing; Malyshkina A.I. – manuscript editing.
Conflicts of interest: The authors confirm that they have no conflicts of interest to declare.
Funding: The study was carried out without any sponsorship.
Ethical Approval: The study was approved by the Ethics Committee of Ivanovo Research Institute of Maternity and Childhood named after V.N. Gorodkov, Ministry of Health of Russia.
Patient Consent for Publication: The patients have signed informed consent for participation in the study and publication of their data.
Authors' Data Sharing Statement: The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator.
For citation: Gerasimov A.M., Malyshkina D.A., Malyshkina A.I. Liver function parameters
in patients with external genital endometriosis and infertility.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2026; (4): 128-133 (in Russian)
https://dx.doi.org/10.18565/aig.2025.316
Keywords
external genital endometriosis
chronic salpingitis
reproductive age
liver function
hyperproliferative diseases
multidisciplinary approach
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Received 30.10.2025
Accepted 09.04.2026
About the Authors
Aleksey M. Gerasimov, Dr. Med. Sci., Professor, Department of Obstetrics, Gynecology and Medical Genetics, Ivanovo State Medical University, Ministry of Health of Russia, 153012, Russia, Ivanovo region, Ivanovo, Sheremetevsky Ave., 8, +7(903)879-33-50, quake98@mail.ru, eLibrary SPIN: 5656-6210, https://orcid.org/0000-0002-6254-1385Darya A. Malyshkina, PhD, Associate Professor at the Department of Obstetrics, Gynecology and Medical Genetics, Academic Director of the Scientific Society of Students and Young Scientists, Ivanovo State Medical University, Ministry of Health of Russia, 153012, Russia, Ivanovo Region, Ivanovo, Sheremetevsky Ave., 8; Оbstetrician-Gynecologist, Ivanovo Research Institute of Maternity and Childhood named after V.N. Gorodkov, Ministry of Health of Russia, 153045, Russia, Ivanovo region, Ivanovo, Pobedy str., 20, +7(920)377-96-99, nidsumi@mail.ru, eLibrary SPIN: 3738-4508, https://orcid.org/0000-0002-1200-3570
Anna I. Malyshkina, Dr. Med. Sci., Professor, Director, Ivanovo Research Institute of Maternity and Childhood named after V.N. Gorodkov, Ministry of Health of Russia, 153045, Russia, Ivanovo region, Ivanovo, Pobedy str., 20; Head of the Department of Obstetrics, Gynecology and Medical Genetics, Ivanovo State Medical University,
Ministry of Health of Russia, 153012, Russia, Ivanovo Region, Ivanovo, Sheremetevsky Ave., 8, +7(910)982-24-19, anna_im@mail.ru, https://orcid.org/0000-0002-1145-0563
Corresponding author: Aleksey M. Gerasimov, quake98@mail.ru
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