Asherman’s syndrome in patients of reproductive age

DOI

https://dx.doi.org/10.18565/aig.2024.150

Sulima A.N., Rumyantseva Z.S., Nikolaeva E.I., Efremova N.V., Bakharovskaya A.S.
Medical Institute named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Simferopol, Russia

Asherman’s syndrome (AS) is an acquired endometrial condition defined by the presence of nonvascular myofibrous intrauterine adhesions and at least one of the following symptoms: history of decreased fertility, recurrent miscarriages, dysmenorrhea, noncyclic pelvic pain, aberrant placentation, or menstrual disorders (amenorrhea, hypomenorrhea, or oligomenorrhea). The review presents a comprehensive analysis and summary of studies on AS, considering the etiology, pathogenesis, diagnosis, advantages and disadvantages of the treatment methods, as well as the latest therapeutic possibilities for intrauterine adhesions. The existing medical literature on the subject accessible via open sources was studied. These sources included the eLibrary (a scientometric database), PubMed (an English-language text database of medical and biological publications), and CyberLeninka (a scientific electronic library). It is essential to consider the findings of the anamnesis, clinical and instrumental studies when selecting an appropriate treatment and prevention of AS. Treatment methods should certainly be aimed at correcting the pathogenetic mechanisms involved in the development of intrauterine adhesions. Hysteroscopy, hormone therapy and the use of intrauterine contraceptives are the traditional methods. Modern techniques such as the use of biomaterials and stem cells are important components of regenerative medicine. The description of treatment, recurrence prevention, and the incidence of AS is a challenging and clinically significant task.
Conclusion: It is worth noting that if uterine surgery is indicated, the risk of developing intrauterine adhesions should be minimized.

Authors’ contributions: Sulima A.N., Rumyantseva Z.S. – developing the concept and design of the study; Nikolaeva E.I., Efremova N.V., Bakharovskaya A.S. – collecting and processing the material, writing the text; Sulima A.N. – editing the text.
Conflicts of interest: Authors declare lack of the possible conflicts of interest.
Funding: The study was conducted without sponsorship. None of the authors has any financial interest in the materials or methods presented.
For citation: Sulima A.N., Rumyantseva Z.S., Nikolaeva E.I., Efremova N.V.,
Bakharovskaya A.S. Asherman’s syndrome in patients of reproductive age.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2024; (10): 19-26 (in Russian)
https://dx.doi.org/10.18565/aig.2024.150

intrauterine adhesions

menstrual cycle disorders

infertility

termination of pregnancy

reproductive age

Asherman’s syndrome

diagnosis

treatment

prevention

Full text (in Russian)

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Received 30.06.2024

Accepted 04.10.2024

Anna N. Sulima, Dr. Med. Sci., Professor, Professor at the Department of Obstetrics, Gynecology and Perinatology № 1, Order of the Labor Red Banner Medical Institute named after S.I. Georgievsky of V.I. Vernadsky Crimean Federal University, 295051, Russia, Republic of Crimea, Simferopol, Lenin blvd., 5/7, +7(978)764-82-00,
gsulima@yandex.ru, https://orcid.org/0000-0002-2671-6985
Zoya S. Rumyantseva, PhD, Associate Professor, Head of the Department of Obstetrics, Gynecology and Perinatology № 1, Order of the Labor Red Banner Medical Institute named after S.I. Georgievsky of V.I. Vernadsky Crimean Federal University, 295051, Russia, Republic of Crimea, Simferopol, Lenin blvd., 5/7, +7(978)855-85-37,
zoyarum@inbox.ru, https://orcid.org/0001-0002-1711-021X
Yelizaveta I. Nikolaeva, Resident Physician at the Department of Obstetrics, Gynecology and Perinatology № 1, Order of the Labor Red Banner Medical Institute named
after S.I. Georgievsky of V.I. Vernadsky Crimean Federal University, 295051, Russia, Republic of Crimea, Simferopol, Lenin blvd., 5/7, +7(978)860-51-88,
yelizavetakaraseva19@gmail.com, https://orcid.org/0000-0002-7316-1062
Natalia V. Efremova, Resident Physician at the Department of Obstetrics, Gynecology and Perinatology № 1, Order of the Labor Red Banner Medical Institute named
after S.I. Georgievsky of V.I. Vernadsky Crimean Federal University, 295051, Russia, Republic of Crimea, Simferopol, Lenin blvd., 5/7, +7(988)252-03-12,
natasha_horunzhaya@mail.ru, https://orcid.org/0000-0002-0494-9358
Anastasiya S. Bakharovskaya, Student at the Department of Obstetrics, Gynecology and Perinatology № 1, Order of the Labor Red Banner Medical Institute
named after S.I. Georgievsky of V.I. Vernadsky Crimean Federal University, 295051, Russia, Republic of Crimea, Simferopol, Lenin blvd., 5/7, +7(978)755-00-78,
nastyabakharovskaya@gmail.com, https://orcid.org/0009-0002-1489-0289
Corresponding author: Anna N. Sulima, gsulima@yandex.ru

Asherman’s syndrome in patients of reproductive age

Sulima A.N., Rumyantseva Z.S., Nikolaeva E.I., Efremova N.V., Bakharovskaya A.S.

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