Possibilities of alternative pharmacological approaches to monotherapy for bacterial vaginosis in reproductive-aged patients
Objective: To present the authors’ own experience with monotherapy for bacterial vaginosis with vaginal gel (Vapigel) in reproductive-aged patients.Lebedenko E.Yu., Gaida O.V., Mikhailenko Ya.V., Anufrieva V.G., Rymashevsky M.A., Sablina N. V., Bespalaya A. V.
Materials and methods: The efficiency and compliance of monotherapy for bacterial vaginosis with intravaginal gel (Vapigel) were evaluated in 30patients on the basis of the time course of changes in clinical symptoms, vaginal fluid pH-metry, the quantitative characteristics of representatives of the vaginal microbiota, and treatment adherence.
Results: Vaginal gel (Vapigel) monotherapy for bacterial vaginosis eliminates subjective complaints and clinical symptoms of the disease in 29/30 (96.7%) patients, determines the detection rate for Lactobacillus spp. at a concentration of107 CFU/ml in 26/30(86.6%), and restores the physiological vaginal discharge pH level in 28/30 (93.3%). Adherence to the use of Vapigel was noted in 25/30 (83.3%) patients; no adverse events were observed in 30/30 (100.0%) patients.
Conclusion: Clinical efficacy, acceptability, absence of adverse events, and treatment refusals determine the advisability of using Vapigel as a monotherapy for bacterial vaginosis in reproductive-aged women as an important component in the implementation of measures to reduce the prescription of antimicrobial drugs in clinical practice.
Keywords
bacterial vaginosis
reproductive age
intravaginal gel
prebiotics
plant polysaccharides
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Received 09.12.2021
Accepted 24.12.2021
About the Authors
Elizaveta Yu. Lebedenko, Doctor of Medicine, Head of the Department of Obstetrics and Gynecology No. 3, Rostov State Medical University, Ministry of Health of Russia, +7(863)252-24-65, Lebedenko08@mailru, 344022, Russia, Rostov-on-Don, per. Nahichevanskiy, 29.Oksana V. Gaida, PhD (Med.), Associate Professor of the Department of Obstetrics and Gynecology, Rostov State Medical University,
Ministry of Health of Russia, gajdaoksana@mail.ru, https://orcid.org/0000-0002-6966-1793, 344022, Russia, Rostov-on-Don, per. Nahichevanskiy, 29.
Yana V. Mikhailenko, obstetrician-gynecologist of the Gynecological Department, Regional Hospital No. 2, Rostov-on-Don, +7(863)252-31-83, yanochka.podina@inboxru, 344023, Russia, Rostov-on-Don, 1st Cavalry Army str., 33.
Mikhail A. Rymashevskiy, assistant of the Department of Obstetrics and Gynecology, Rostov State Medical University, Ministry of Health of Russia, +7(863)285-32-13, mikhail.rymashevskiy@mail.ru, 344022, Russia, Rostov-on-Don, per. Nahichevanskiy, 29.
Vitaliya G. Anufrieva, obstetrician-gynecologist of the Gynecological Department, Rostov State Medical University, Ministry of Health of Russia, +7(863)234-38-66, vitaliya@list.ru, 344022, Russia, Rostov-on-Don, per. Nahichevanskiy, 29. Tel.:
Natalya V. Sablina, obstetrician-gynecologist, Gynecological Department, Botkin Hospital, Moscow Healthcare Department, +7(495)677-16-11, natalie_sablina@yahoo.de, https://orcid.org/0000-0002-8068-120Х, 125284, Russia, Moscow, 2nd Botkinsky pr-d, 5
Angelina V. Bespalaya, оbstetrician-gynecologist of the Maternity Department, State Perinatal Center of the Rostov Region, +7(863)235-50-18, angelina-koshka@yandex.ru, 344068, Russia, Rostov-on-Don, Bodraya str., 90.
Corresponding author: Elizaveta Yu. Lebedenko, Lebedenko08@mail.ru
Authors’ contributions: Lebedenko E.Yu. - research coordinator, development of the design of the investigation and its protocol, IRC, analysis of the findings, editing the text; Gaida O.V., Rymashevsky M.A. - collection and analysis of the findings, writing the text; Mikhailenko Ya.V., Anufrieva V.G., Sablina N.V., Bespalaya A.V. - collection and analysis of the findings.
Conflicts of interest: The authors declare that there are possible conflicts of interest.
Funding: The clinical trial has been conducted with the support of the Kinetik-Farm LLC, Russian Federation.
Patient Consent for Publication: All patients provided informed consent for the publication of their data.
Authors' Data Sharing Statement: The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator.
For citation: Lebedenko E.Yu., Gaida O.V., Mikhailenko Ya.V., Anufrieva V.G., Rymashevsky M.A., Sablina N. V., Bespalaya A. V. Possibilities of alternative pharmacological approaches to monotherapy for bacterial vaginosis in reproductive-aged patients. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2022; 1:129-134 (in Russian)
https://dx.doi.org/10.18565/aig.2022.1.129-134
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