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The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
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Obstetrics and Gynegology2026№2

Oxidant–antioxidant profile of the endometrium: pathogenesis of hyperplastic processes

DOI
https://dx.doi.org/10.18565/aig.2026.26

Boldyreva A.A, Shcherbakova L.N., Bugerenko A.E., Ogay D.S., Sichinava L.G., Panina O.B.

1) Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, Moscow, Russia; 2) Lomonosov Moscow State University, Medical Research and Education Institute, Moscow, Russia; 3) N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia

Endometrial hyperplasia and endometrial cancer represent a major clinical burden and continue to raise substantial pathophysiological questions. Disturbances in redox homeostasis are increasingly recognized as an important contributor to the molecular landscape underlying the initiation and progression of these disorders. This review synthesizes clinical and experimental data exploring the redox profile of the endometrium in non-atypical and atypical hyperplasia, as well as in endometrial cancer, with the goal of integrating biochemical findings into a coherent framework for interpreting clinical phenotypes.
Evidence suggests that redox imbalance emerges early, already in non-atypical endometrial hyperplasia, and is characterized by enhanced lipid peroxidation, depletion of thiol groups, and reduced activities of key antioxidant enzymes. Atypical hyperplasia demonstrates a more heterogeneous redox phenotype, reflecting compensatory or adaptive cellular responses. In endometrial cancer, redox dysregulation becomes functionally bifurcated: moderate levels of reactive oxygen species (ROS) promote proliferative and survival signaling, whereas excessive ROS accumulation initiates programmed cell death pathways. Clinical studies increasingly report correlations between redox biomarkers and tumor burden, metastatic potential, patient survival, and treatment responsiveness, underscoring their prognostic relevance.
Conclusion: Current evidence confirms the potential of redox biomarkers in diagnostic assessment of hyperplastic and malignant endometrial disorders, since their changes correlate with the characteristics of the course of the disease, the extent of the tumor, and the response to treatment. Incorporating indicators of oxidant–antioxidant balance into routine evaluation may enhance risk stratification and support more individualized therapeutic decision-making.

Authors’ contributions: Boldyreva A.A. – developing the concept of the study, search and analysis of literature data, writing the text; Shcherbakova L.N. – developing the concept of the study, reviewing and editing the manuscript, final approval of the version for publication; Bugerenko A.E. Ogay D.S. – search and analysis of literature data; Sichinava L.G., Panina O.B. – scientific consulting, editing and final approval of the version for publication.
Conflicts of interest: The authors declare that there are no conflicts of interest.
Funding: The study was conducted within the framework of the state assignment of the Lomonosov Moscow State University.
For citation: Boldyreva A.A, Shcherbakova L.N., Bugerenko A.E., Ogay D.S., Sichinava L.G., Panina O.B.
Oxidant-antioxidant profile of the endometrium: pathogenesis of hyperplastic processes.
Akusherstvo i Ginekologiy/Obstetrics and Gynecology. 2026; (2): 70-77 (in Russian)
https://dx.doi.org/10.18565/aig.2026.26

Keywords

endometrial hyperplasia
atypical endometrial hyperplasia
endometrial cancer
oxidative stress
antioxidant system
reactive oxygen species
lipid peroxidation
biomarkers
Full text (in Russian)

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Received 28.01.2026

Accepted 11.02.2026

About the Authors

Anastasia A. Boldyreva, obstetrician-gynecologist, Junior Researcher at the Department of Aesthetic Gynecology and Rehabilitation, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russia, 4 Ac. Oparin str., Moscow, 117997, Russia; PhD student, Department of Obstetrics and Gynecology, Faculty of Fundamental Medicine, Medical Research and Education Institute, Lomonosov Moscow State University, 27-1 Lomonosovsky Ave., Moscow, 119991, Russia, boldyreva.anastasi@gmail.com, https://orcid.org/0009-0003-4679-3229
Liya N. Shcherbakova, Dr. Med. Sci., Associate Professor at the Department of Obstetrics and Gynecology, Faculty of Fundamental Medicine, Medical Research and Education Institute, Lomonosov Moscow State University, 27-1 Lomonosovsky Ave., Moscow, 119991, Russia, liya.fbm@gmail.com, https://orcid.org/0000-0003-2681-4777
Andrey E. Bugerenko, Dr. Med. Sci., Associate Professor at the Department of Obstetrics and Gynecology, Faculty of Fundamental Medicine, Medical Research and Education Institute, Lomonosov Moscow State University, 27-1 Lomonosovsky Ave., Moscow, 119991, Russia, jeddit@yandex.ru, https://orcid.org/0000-0001-5691-7588
Dmitry S. Ogay, Dr. Med. Sci., Head of the Department of Breast Tumors and Gynecologic Oncology, University Clinic, Medical Research and Education Institute,
Lomonosov Moscow State University, 27-1 Lomonosovsky Ave., Moscow, 119991, Russia, dogay2008@yandex.ru, https://orcid.org/0009-0009-1723-5336
Lali G. Sichinava, Dr. Med. Sci., Professor, G.M. Savelyeva Department of Obstetrics and Gynecology, Faculty of Pediatrics, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, 1-6 Ostrovityanov str., Moscow, 117513, Russia, lalisichinava@gmail.com, https://orcid.org/0000-0003-0820-4772
Olga B. Panina, Dr. Med. Sci., Head of the Department of Obstetrics and Gynecology, Professor, Department of Obstetrics and Gynecology, Faculty of Fundamental Medicine, Medical Research and Education Institute, Lomonosov Moscow State University, 27-1 Lomonosovsky Ave., Moscow, 119991, Russia, olgapanina@yandex.ru,
https://orcid.org/0000-0003-1397-6208

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