The potential role of the nervous system in endometrial cancer and endometrial hyperplasia as one of the risk factors for neotransformation

DOI

https://dx.doi.org/10.18565/aig.2024.126

Levakov S.A., Gromova T.A., Gvazava E.N.
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia, Moscow, Russia

Endometrial hyperplasia is one of the common pathologies of the uterine mucosa among reproductive-aged patients. It can be considered as a potential risk factor for malignant transformation of the endometrium with subsequent development of endometrioid adenocarcinoma. Studies have demonstrated that the presence of nerve fibres is a part of the malignant microenvironment that plays an active role in tumour progression and invasion. Due to the increasing rate of these conditions, it is relevant to consider the relationship of uterine nerve fibres with the possible development and progression of endometrial adenocarcinoma. Endometrial hyperplasia may serve as an indicator for the development of this cancer. This review also describes the possible promising role of nicotinic acetylcholine receptors in hyperplastic changes and endometrial cancer.
Conclusion: Further research is required to establish the interactions between hormonal status, uterine nerve fibres and the development of endometrial cancer which could lead to a broader range of diagnostic and prognostic possibilities. These aspects may also help to guide the development of innovative medicines for this group of patients, thereby improving outcomes and quality of life.

Authors’ contributions: Levakov S.A. – developing the concept of the study; Gromova T.A., Gvazava E.N. – collecting and processing the material, writing the text; Levakov S.A., Gromova T.A. – editing the text.
Conflicts of interest: Authors declare lack of the possible conflicts of interests.
Funding: The study was conducted without sponsorship.
For citation: Levakov S.A., Gromova T.A., Gvazava E.N. The potential role of the nervous system in
endometrial cancer and endometrial hyperplasia as one of the risk factors for neotransformation.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2024; (10): 27-33 (in Russian)
https://dx.doi.org/10.18565/aig.2024.126

endometrial hyperplasia

uterine cancer

nervous system

nicotinic acetylcholine receptors

Full text (in Russian)

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Received 27.05.2024

Accepted 16.10.2024

Sergey A. Levakov, Dr. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology, N.V. Sklifosovsky ICM, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), 119991, Russia, Moscow, Trubetskaya str., 8-2, +7(495)609-14-00, levakoff@yandex.ru,
https://orcid.org/0000-0002-4591-838X
Tatyana A. Gromova, PhD, Teaching Assistant at the Department of Obstetrics and Gynecology, N.V. Sklifosovsky ICM, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), 119991, Russia, Moscow, Trubetskaya str., 8-2, +7(495)609-14-00, tgromova928@yandex.ru,
https://orcid.org/0000-0001-6104-9842
Ekaterina N. Gvazava, PhD student at the Department of Obstetrics and Gynecology, N.V. Sklifosovsky ICM, I.M. Sechenov First Moscow State Medical University,
Ministry of Health of Russia (Sechenov University), 119991, Russia, Moscow, Trubetskaya str., 8-2, +7(495)609-14-00, https://orcid.org/0000-0001-9062-5351

The potential role of the nervous system in endometrial cancer and endometrial hyperplasia as one of the risk factors for neotransformation

Levakov S.A., Gromova T.A., Gvazava E.N.

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