Clinical portrait of female patients and causes of early pregnancy failure in the Tyumen region
Dikke G.B., Sukhanov A.A., Kukarskaya I.I., Shilova N.V.
Objective. To assess the prevalence of early pregnancy failure (EPF) in the Tyumen region and to identify the most significant social and clinical features of women with EPF.
Materials and methods. We used statistical data from the Ministry of Health of the Tyumen Region, covering both the period of 2021–2025 and visits to the Tyumen Perinatal Center. The analytical data enrolled 1,457 patients with EPF. Examination methods covered history data, gynecological examination, pelvic ultrasound, and histological examination of gestational tissue.
Results. The prevalence of spontaneous miscarriages (SM) among all pregnant women in the Tyumen region averaged 14.0% over a 5-year period. The percentage of SM within EPF was 49.0%, with the incidence of SM increasing by 5.2% and EPF by 2.0% from 2021 to 2025. Anembryonic type EPF was observed in an average of 12.0% of patients, and embryonic death type EPF – in 88.0%. The percentage of SM among the total number of patients registered at the Tyumen Perinatal Center was 54.3%, while the EPF proportion within SM was 97.6%. EPF of the anembryonic type was observed in 13.8% of patients, with the embryonic death type – in 86.2%. Over a five-year period, the clinical profile of patients with EPF observed at the Tyumen Perinatal Center underwent changes, characterized by a 1.5-fold increase in the patients aged over 41 and an increase in genetically specified losses from 11.8 to 15.1% (p<0.001). A statistically significant increase in the number of unsuccessful ART cycles was revealed in EPF patients (from 1 to 4 in the upper quartile Q3; p=0.003), indicating a concentration of women with severe forms of reproductive dysfunction. A high prevalence of chronic endometritis (80.2%) was noted due to an increase in risky sexual behavior associated with social factors, and a shift in the period of ultrasound EPF finding from 6 to 7 weeks of gestation.
Conclusion. Following stable incidence of SM over the period of 2021–2025 (approximately 14%), an increase in SM and EPF with embryonic death being the predominant cause was recorded in the Tyumen Region. The clinical profile of patients diagnosed with EPF at the Tyumen Perinatal Center is characterized by an increased number of women of late reproductive age with a history of unsuccessful ART attempts, an increased number of genetic abnormalities, a high incidence of chronic endometritis, and an upward shift in the median ultrasound diagnosis of EPF by one week.
Authors’ contributions. Dikke G.B. – study concept and design, study planning, statistical analysis of clinical material processing and its interpretation, search for sources, writing of fragments of the article and article editing after review; Sukhanov A.A. – collection of clinical material, formation of an electronic database, writing of fragments of the article; Kukarskaya I.I. – organization of the study, supervision; Shilova N.V. – statistical analysis of the study results, writing of article fragments.
Conflicts of interest. The authors declare no conflict of interest and guarantee that the article is the original research.
Funding. The study was funded by the authors themselves. Publication of the article was supported by Biotekhpharm OOO.
Generative Artificial Intelligence. The authors declare that they did not use artificial intelligence technologies for the article conduction.
Authors' Data Sharing Statement. The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator.
For citation: Dikke G.B., Sukhanov A.A., Kukarskaya I.I., Shilova N.V.
Clinical portrait of female patients and causes of early pregnancy failure in the Tyumen region.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2026; (8): 154-162 (in Russian)
https://dx.doi.org/10.18565/aig.2026.223
Keywords
spontaneous miscarriage
non-developing pregnancy
anembryonic pregnancy
embryonic death
epidemiology
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Received 16.07.2026
Accepted 14.08.2026
About the Authors
Galina B. Dikke, Dr. Med. Sci., Professor, Department of Obstetrics and Gynecology with a Course of Reproductive Medicine, Academy of Medical Education namedafter F.I. Inozemtsev, 22 Liter M, Moskovskiy Ave., Saint Petersburg, 190013, Russia, galadikke@yandex.ru, https://orcid.org/0000-0001-9524-8962
Anton A. Sukhanov, Dr. Med. Sci., Head of the Gynecology Department, Tyumen Perinatal Center, 1 Daudelnaya str., Tyumen, 625002, Russia; Associate Professor, Department of Obstetrics and Gynecology, Tyumen State Medical University, Ministry of Health of Russia, 10 Permyakov str., Tyumen, 625013, Russia,
saa2505anton@yandex.ru, https://orcid.org/0000-0001-9092-9136
Irina I. Kukarskaya, Dr. Med. Sci., Associate Professor, Head of the Department of Obstetrics, Gynecology, and Perinatology, Institute of Maternal and Child Health, Tyumen State Medical University, Ministry of Health of Russia, 10 Permyakov str., Tyumen, 625013, Russia; Chief Physician, Tyumen Perinatal Center, 1 Daudelnaya str., Tyumen, 625002, Russia; Chief Specialist in Obstetrics and Gynecology, Department of Health of the Tyumen Region, kukarskay@mail.ru, https://orcid.org/0000-0002-8275-3553
Natalya V. Shilova, PhD, Associate Professor, Department of Industrial Pharmacy, National Research Nuclear University MEPhI (Moscow Engineering Physics Institute),
31 Kashirskoe shosse, Moscow, 115409, Russia, nvshilova@gmail.com, https://orcid.org/0000-0001-6734-0147
Corresponding author: Galina B. Dikke, galadikke@yandex.ru
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