A study of risk factors for preeclampsia in pregnant women aged over 35 living in Southern Kyrgyzstan (Osh region)
Subanova G.A., Askerov A.A., Subanova N.A., Yrysbaev E.Y., Yrysbaev A.Y., Muratova G.K., Ikhtiyarova G.A., Karybekova A.M.
Objective. To study the prevalence and risk factors for severe preeclampsia in pregnant women aged over 35 living in southern Kyrgyzstan (Osh Region).
Materials and methods. A retrospective analysis was carried out of 67 birth records at the Osh Interregional Clinical Hospital (2022–2024). The studies included the following groups: women with preeclampsia younger than 35 years (n=39), aged 35 years or older (n=21), and a control group without hypertension (n=7). The statistical analysis was performed using Fisher’s exact test, OR with a 95% CI.
Results. Severe preeclampsia was diagnosed in 73.1% of cases. Significant risk factors were life at high altitude (p=0.008), parity of ≥4 births (p=0.04), a complicated obstetric history (p=0.039), anemia (p=0.048) and being a housewife (p=0.018). The age group ≥35 years demonstrated a trend (p=0.12). Headache, nausea and oedema were observed in 80–92% of severe cases (p<0.001).
Conclusion. In this sample, severe preeclampsia is associated with environmental, social and obstetric factors. Early prevention and close monitoring are necessary for multiparous rural women aged over 35.
Authors’ contributions. Subanova N.A., Askerov A.A. – developing the concept and design of the study; Subanova G.A., Muratova G.K. – collecting and processing the data; Yrysbaev A.Y, Karybekova A.M. – statistical analysis of the data; Yrysbaev E.Y. – writing the text; Ikhtiyarova G.A. – editing the article.
Conflicts of interest. Authors declare lack of the possible conflicts of interests.
Funding. The study was conducted without sponsorship.
Ethical Approval. The study was approved by the Committee on Biomedical Ethics of the International Medical Faculty, Osh State University on February 17, 2025.
Generative Artificial Intelligence. Generative artificial intelligence technologies were not used in preparing this article.
Patient Consent for Publication. The patients signed informed consent for the publication of their data.
Authors' Data Sharing Statement. The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator.
For citation: Subanova G.A., Askerov A.A., Subanova N.A., Yrysbaev E.Y., Yrysbaev A.Y., Muratova G.K.,
Ikhtiyarova G.A., Karybekova A.M. A study of risk factors for preeclampsia in pregnant women
aged over 35 living in Southern Kyrgyzstan (Osh region).
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2026; (7): 145-152 (in Russian)
https://dx.doi.org/10.18565/aig.2025.360
Keywords
preeclampsia
severe preeclampsia
risk factors
age ≥35 years
Kyrgyzstan
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Received 08.12.2025
Accepted 11.06.2026
About the Authors
Guljamal A. Subanova, PhD, Associate Professor at the Department of Obstetrics, Gynecology, and Surgical Disciplines, International Medical Faculty, Osh State University, Kyrgyzstan, Osh city, Abiy Kabylov str., 215/2, build. 2, +996(772)23-05-19, gsubanova@oshsu.kg, https://orcid.org/0000-0003-1003-678XArsen A. Askerov, Dr. Med. Sci., Associate Professor, Head of the Department of Clinical Disciplines, Bishkek International Medical Institute, 720065, Kyrgyzstan, Bishkek city, Shabdan Baatyr Ave., 4a, +996(550)33-17-31, askerov.arsen@inbox.ru, https://orcid.org/0000-0003-4447-9650
Nargiza A. Subanova, Teaching Assistant at the Department of Obstetrics and Gynecology No. 2, I.K. Akhunbaev Kyrgyz State Medical Academy, 720020, Kyrgyzstan, Bishkek city, Isa Akhunbaev str., 92, 1st floor, +996(507)50-55-05, nargiza.subanova@bk.ru, https://orcid.org/0000-0003-1455-7902
Erzamat Y. Yrysbaev, Lecturer at the Department of Public Health with the Course of Evidence-Based Medicine, International Medical Faculty, Osh State University, Kyrgyzstan, Osh city, Abiy Kabylov str., 215/2, build. 1, +996(706)82-03-50, yrysbaev@oshsu.kg, https://orcid.org/0000-0003-0476-2654
Azmat Y. Yrysbaev, Lecturer at the Department of Morphophysiological Disciplines, International European University, 720080 Kyrgyzstan, Bishkek city, Mukhtar Auezov str., 3, +996(704)24-52-96, yrysbaev1996@gmail.com, https://orcid.org/0009-0009-4978-994X
Gulkayir K. Muratova, PhD, Department of Obstetrics and Gynecology, Medical Faculty, Osh State University, Kyrgyzstan, Osh city, Abiy Kabylov str., 215/2, build. 2, +996(555)12-11-91, gulkayir78@gmail.com, https://orcid.org/0000-0002-2425-1854
Gulchekhra A. Ikhtiyarova, Professor, Dr. Med. Sci., Head of the Department of Obstetrics and Gynecology, Bukhara State Medical Institute named after Abu Ali ibn Sina, Uzbekistan, Bukhara city, Gijduvan str., 23, +998(90)205-25-52, ixtiyarova7272@mail.ru, https://orcid.org/0000-0002-2398-3711
Aizhan M. Karybekova, Lecturer, Southern branch of the Kyrgyz State Medical Institute of Retraining and Advanced Training named after S.B. Daniyarov, Osh, Kyrgyzstan, +996777855385, erikosor99@gmail.com, https://orcid.org/0009-0006-4503-1427
Corresponding author: Erzamat Y. Yrysbaev, yrysbaev@oshsu.kg
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