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The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
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Obstetrics and Gynegology2026№3

The association of polymorphic loci affecting sex hormone-binding globulin levels with the risk of isolated uterine myoma

DOI
https://dx.doi.org/10.18565/aig.2025.255

Ponomarenko M.S., Reshetnikov E.A., Churnosova M.M., Churnosov M.I., Ponomarenko I.V.

Belgorod State National Research University, Belgorod, Russia

Objective: To evaluate the role of polymorphic variants in genes associated with sex hormone-binding globulin (SHBG) levels in the development of isolated uterine myomas.
Materials and methods: The study group comprised 192 patients with isolated uterine myomas and 973 healthy women (controls). Molecular genetic analysis was performed on five gene loci associated with SHBG levels based on data from genome-wide studies: rs8023580 [T/C] NR2F2 (chromosome 15), rs780093 [C/T] GCKR (chromosome 2), rs3779195 [T/A] BAIAP2L1 (chromosome 7), rs7910927 [G/T] JMJD1C (chromosome 10), and rs4149056 [T/C] SLCO1B1 (chromosome 12). Logistic regression with the gPLINK program was used to study the association between polymorphic loci of SHBG candidate genes and the development of isolated uterine fibroids.
Results: An association was found between the rs3779195 [T/A] polymorphism in the BAIAP2L1 gene and the development of isolated uterine fibroids (OR=1.44 for the A allele in the dominant model). The rs3779195 [T/A] polymorphism of BAIAP2L1 and 20 SNPs in linkage disequilibrium with it are functionally significant. These polymorphisms are associated with the interaction of DNA in the BAIAP2L1/BRI3 gene region with 86 transcription factors and regulatory proteins, and with the transcription of 15 genes and splicing of three genes in various organs and tissues related to the pathophysiology of uterine fibroids.
Conclusion: The molecular genetic marker rs3779195 [T/A] of the BAIAP2L1 gene is associated with an increased risk of developing uterine fibroids.

Authors' contributions: Ponomarenko M.S. – conception and design of the study, data synthesis, drafting of the manuscript; Reshetnikov E.A. – drafting of the manuscript; Churnosova M.M. – literature search and analysis; Churnosov M.I. – review, final editing; Ponomarenko I.V. – statistical analysis, editing of the manuscript.
Conflicts of interest: The authors have no conflicts of interest to declare.
Funding: The study was conducted with the support of Russian Science Foundation grant No. 25-25-00034, https://rscf.ru/project/25-25-00034/.
Ethical Approval: The study was reviewed and approved by the Research Ethics Committee of the Belgorod State National Research University.
Patient Consent for Publication: All patients provided informed consent for the publication of their data.
Authors' Data Sharing Statement: The data supporting the findings of this study are available upon request from the corresponding author after approval from the principal investigator.
For citation: Ponomarenko M.S., Reshetnikov E.A., Churnosova M.M., Churnosov M.I., Ponomarenko I.V. 
The association of polymorphic loci affecting sex hormone-binding globulin levels with the risk of isolated uterine myoma.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2026; (3): 104-110 (in Russian)
https://dx.doi.org/10.18565/aig.2025.255

Keywords

uterine myoma
polymorphism
sex hormone-binding globulin
Full text (in Russian)

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Received 17.09.2025

Accepted 12.02.2026

About the Authors

Marina S. Ponomarenko, PhD student at the Department of Biomedical Disciplines, Belgorod State National Research University, 308015, Russia, Belgorod, Pobedy str., 85, +7(4722)30-13-83, ponomarenkomc@yandex.ru, https://orcid.org/0009-0009-0312-0829
Evgeny A. Reshetnikov, Dr. Sci. (Bio), Professor at the Department of Medical and Biological Disciplines, Belgorod State National Research University, 308015, Russia, Belgorod, Pobedy str., 85, +7(4722)30-13-83, reshetnikov@bsuedu.ru, http://orcid.org/0000-0002-5429-6666
Maria M. Churnosova, student at the Medical Institute, Belgorod State National Research University, 308015, Russia, Belgorod, Pobedy str., 85, +7(4722)30-13-83, churnosovamary@gmail.com, https://orcid.org/0000-0001-6444-8806
Mikhail I. Churnosov, Dr. Med. Sci., Head of the Department of Medical and Biological Disciplines, Belgorod State National Research University, 308015, Russia, Belgorod, Pobedy str., 85, +7(4722)30-13-83, churnosov@bsuedu.ru, http://orcid.org/0000-0003-1254-6134
Irina V. Ponomarenko, Dr. Med. Sci., Professor at the Department of Medical and Biological Disciplines, Belgorod State National Research University, 308015, Russia, Belgorod, Pobedy str., 85, +7(4722)30-13-83, ponomarenko_i@bsuedu.ru, https://orcid.org/0000-0002-5652-0166
Corresponding author: Irina V. Ponomarenko, ponomarenko_i@bsuedu.ru

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