Antiphosphatidylserine/prothrombin complex antibodies in patients with healthy pregnancies
Ischuk V.V., Kerchelaeva S.B., Aleksandrova E.N., Novikov A.A., Khashukoeva I.Z.
Antiphosphatidylserine/prothrombin complex (aPS/PT) antibodies are an additional set of biomarkers that can be used to detect thromboembolic and obstetric complications, in addition to the traditional panel of phospholipid antibodies.
Objective: To determine aPS/PT levels in patients with healthy pregnancies.
Materials and methods: A study of serum aPS/PT IgG and IgM levels was conducted in 50 pregnant women with normal pregnancies during the first, second, and third trimesters of gestation.
Results: The median level of aPS/PT IgG in pregnant women during the first trimester was 3.77
(2.67; 5.72) U/ml; in the second trimester, it was 3.48 (2.93; 5.39) U/ml; and in the third trimester, it was 3.72 (3.02; 4.79) U/ml. The median level of aPS/PT IgM in these patients was 3.6 (2.61; 5.09) U/ml in the first trimester; 4.1 (2.65; 5.4) U/ml in the second trimester; and 5.0 (3.41; 6.38) U/ml in the third trimester. Statistically significant changes were observed only in the third trimester (p=0.018).
Conclusion: The scientific community recognizes aPS/PT among non-criterial phospholipid antibodies as a promising diagnostic marker that may enhance the effectiveness of antiphospholipid syndrome diagnosis. Further studies involving patients with complicated pregnancies are needed to determine the significance of aPS/PT and confirm their potential use in the clinical practice of obstetricians and gynecologists.
Authors' contributions: Ischuk V.V. – patient examination, review of the relevant literature, drafting of the manuscript; Kerchelaeva S.B. – conception and design of the study, drafting and editing of the manuscript; Aleksandrova E.N. – collection and analysis of literature sources, drafting of the manuscript; Novikov A.A. – literature review, patient examination, drafting of the manuscript; Khashukoeva I.Z. – literature review, drafting of the manuscript. All of the authors contributed significantly to developing the concept, conducting the study, and drafting of the manuscript. They all read and approved the final version before submission.
Conflicts of interest: The authors have no conflicts of interest to declare.
Funding: There was no funding for this study.
Ethical approval: The study was reviewed and approved by the Research Ethics Committee of the Pirogov RNRMU, Ministry of Health of Russia (Ref. No: 236 of 22.01.2024).
Patient Сonsent for Publication: All patients provided informed consent for the publication of their data.
Authors' Data Sharing Statement: The data supporting the findings of this study are available upon request from the corresponding author after approval from the principal investigator.
For citation: Ischuk V.V., Kerchelaeva S.B., Aleksandrova E.N., Novikov A.A., Khashukoeva I.Z. Antiphosphatidylserine/prothrombin complex antibodies in patients with healthy pregnancies.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2025; (11): 70-76 (in Russian)
https://dx.doi.org/10.18565/aig.2025.292
Keywords
antibodies to the phosphatidylserine/prothrombin complex
antiphospholipid antibodies
pregnancy
childbirth
antiphospholipid syndrome
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Received 17.10.2025
Accepted 11.11.2025
About the Authors
Valeriya V. Ischuk, PhD student at the Departments of Obstetrics and Gynecology, Institute of Surgery, N.I. Pirogov Russian National Research Medical University,Ministry of Health of Russia, 117513, Russia, Moscow, Ostrovityanova str., 1. lerchonokmark@mail.ru, https://orcid.org/0000-0003-4328-2370
Svetlana B. Kerchelaeva, Dr. Med. Sci., Professor at the Departments of Obstetrics and Gynecology, Institute of Surgery, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, 117513, Russia, Moscow, Ostrovityanova str., 1, ksb65@mail.ru, https://orcid.org/0000-0002-4411-4478
Elena N. Aleksandrova, Dr. Med. Sci., Head of the Laboratory of Clinical Immunology, A.S. Loginov Moscow Clinical Scientific Center, Moscow Healthcare Department, 111123, Russia, Moscow, Novogireevskaya str., 1, aleksandrovaen2015@yandex.ru, https://orcid.org/0000-0003-4074-5907
Alexander A. Novikov, Dr. Bio. Sci., Leading Researcher at the Laboratory of Clinical Immunology, A.S. Loginov Moscow Clinical Scientific Center, Moscow Healthcare Department, 111123, Russia, Moscow, Novogireevskaya str., 1, irramnlab@yandex.ru, https://orcid.org/0000-0002-2738-2956
Ilona Z. Khashukoeva, student, H.M. Berbekov Kabardino-Balkarian State University, 360004, Russia, Nalchik, Chernyshevsky str., 173, ilona_1017@mail.ru,
https://orcid.org/0009-0000-4378-910X
Corresponding author: Valeriya V. Ischuk, lerchonokmark@mail.ru
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