Anti-Mullerian hormone in adolescent girls: physiology, clinical role, and the results of the study
Kolsanova A.V., Kartashova P.V., Dufinets I.E., Tarasova V.G., Chombaeva S.T., Zubova M.A.
Background: Anti-Mullerian hormone (AMH) is known to be a key marker of ovarian function. It reflects the number of growing follicles and the level of ovarian reserve. The clinical significance of this indicator is poorly studied during the period of adolescence, which limits its use for the early diagnosis of reproductive disorders.
Objective: To study the relationship between AMH levels and a complex of genetic and environmental factors in adolescent girls.
Materials and methods: 48 girls aged 15–17 with no burden of pathology were enrolled in the study. A clinical and anamnestic examination, questionnaires, assessment of menstrual function parameters and psychoemotional state, as well as testing of AMH levels using an enzyme-linked immunosorbent assay were conducted. Spearman's correlation coefficient was used to evaluate relationships between the above-mentioned indicators.
Results: We identified a statistically significant weak positive correlation between the age and AMH level (R=0.378; p=0.008), which reflects the physiological age-related dynamics in the formation of ovarian reserve during puberty. Other parameters, including anthropometric indicators, menstrual function characteristics, lifestyle and psycho-emotional state, did not demonstrate a statistically significant link with hormone levels.
Conclusion: AMH levels in healthy adolescent girls are primarily age-associated and are independent of anthropometric, behavioral, and psychological factors. Our findings confirm the physiological nature of age-related changes in ovarian reserve and highlight the need to develop age-specific standards.
Authors’ contributions: Kolsanova A.V. – study concept and design; Kartashova P.V., Dufinets I.E. – data collection and processing; Tarasova V.G. – literature review, article text writing; Chombaeva S.T., Zubova M.A. – data collection. The authors declare the compliance of their authorship according to the international ICMJE criteria.
Conflicts of interest: The authors declare no conflicts of interest.
Funding: The authors declare that there is no external funding for the exploration and analysis work.
Ethical Approval: The study protocol was approved by the local ethics committee of the Samara State Medical University, Ministry of Health of Russia. The study was conducted in accordance with the principles of the Declaration of Helsinki.
Patient Consent for Publication: The authors obtained the written consent of the patient's legal representatives for the analysis and publication of medical data.
Authors' Data Sharing Statement: The authors declare the possibility of providing the original data upon reasonable request.
For citation: Kolsanova A.V., Kartashova P.V., Dufinets I.E., Tarasova V.G., Chombaeva S.T., Zubova M.A.
Anti-Mullerian hormone in adolescent girls: physiology, clinical role, and the results of the study.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2026; (4): 168-174 (in Russian)
https://dx.doi.org/10.18565/aig.2026.118
Keywords
anti-Mullerian hormone
ovarian reserve
puberty
adolescent girls
prediction
family planning
fertility
References
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Received 09.04.2026
Accepted 17.04.2026
About the Authors
Anna V. Kolsanova, Dr. Med. Sci., Associate Professor, Head of the Department of Obstetrics and Gynecology, Samara State Medical University, Ministry of Health of Russia, 443099, Russia, Samara, Chapaevskaya str., 89, a.v.kazakova@samsmu.ru, https://orcid.org/0000-0002-9483-8909Polina V. Kartashova, Teaching Аssistant, Department of Obstetrics and Gynecology of the Institute of Pediatrics, Samara State Medical University, Ministry of Health of Russia, 443099, Russia, Samara, Chapaevskaya str., 89, https://orcid.org/0009-0003-1340-5154
Victoria G. Tarasova, Resident, Department of Obstetrics and Gynecology of the IPE, Samara State Medical University, Ministry of Health of Russia, 443099, Russia, Samara, Chapaevskaya str., 89, https://orcid.org/0009-0000-6818-2056
Irina E. Dufinets, PhD, Associate Professor, Department of Obstetrics and Gynecology, Samara State Medical University, Ministry of Health of Russia, 443099, Russia, Samara, Chapaevskaya str., 89, https://orcid.org/0000-0002-2281-6495
Sogdiana T. Chombaeva, 5th year student, Institute of Pediatrics, Samara State Medical University, Ministry of Health of Russia, 443099, Russia, Samara, Chapaevskaya str., 89.
Milana A. Zubova, 5th year student, Institute of Pediatrics, Samara State Medical University, Ministry of Health of Russia, 443099, Russia, Samara, Chapaevskaya str., 89.
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