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The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
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Obstetrics and Gynegology2025№10

Organ-preserving treatment of borderline ovarian tumors: modern surgical strategies and reproductive outcomes

DOI
https://dx.doi.org/10.18565/aig.2025.211

Petrozhitskaya A.A., Tandelov R.K., Bendzhenova B.B., Morkhov K.Yu., Martirosyan Ya.O., Biryukova A.M.

Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, Moscow, Russia

Borderline ovarian tumors (BOT) are a unique type of epithelial neoplasms that mainly affect women of reproductive age. Due to their favorable course and high detection rate in the early stages, organ-preserving treatment is becoming a top priority, especially for patients planning a pregnancy.
Objective: To summarize and systematize current data on oncological safety, surgical approaches, reproductive outcomes, and the role of assisted reproductive technologies (ART) in patients with BOT who had a previous history of fertility-sparing treatment.
Materials and methods: The literature was searched using PubMed, Scopus, Web of Science, and CNKI databases. The review article included original studies with more than 20 patients. The studies provided the data on the types of surgery, disease recurrence and reproductive outcomes. The total sample included 4,586 patients.
Results: The lowest recurrence rate after fertility sparing surgery (FSS) was observed in ultrasound guided ovarian wedge resection (UGOWR) (0–3%); intermediate rate was observed in unilateral salpingo-oopherectomy (USO) (10–15%); maximum rate was noted in cystectomy (25–31%); micropapillary serous variant is associated with a recurrence risk of up to 45%. In the total sample of 4,586 patients, the pregnancy rate after FSS was 39–52%, the proportion of live births was up to 30%, miscarriages were ~11%, and premature births were 9%; ART was effective after thorough selection (8.6–20% recurrences, more often after cystectomy); full staging procedure reduces recurrence rate to 8–12% versus 30–40% without staging.
Conclusion: Organ-preserving interventions in BOT are oncologically justified if there is an individualized approach combined with complete surgical staging; UGOWR demonstrates the best profile of oncological safety and fertility preservation, and the use of ART is acceptable in specialized centers with controlled stimulation.

Authors’ contributions: Petrozhitskaya A.A. – developing the research design; Tandelov R.K. – review of publications on the subject of the article; Bendzhenova B.B. – analysis of the obtained data; Morkhov K.Yu., Martirosyan Ya.O., Biryukova A.M. – writing the text of the manuscript.
Conflicts of interest: The authors declare that there are no conflicts of interest.
Funding: The study was conducted without sponsorship.
For citation: Petrozhitskaya A.A., Tandelov R.K., Bendzhenova B.B., Morkhov K.Yu., Martirosyan Ya.O., Biryukova A.M. Organ-preserving treatment of borderline ovarian tumors: 
modern surgical strategies and reproductive outcomes.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2025; (10): 30-35 (in Russian)
https://dx.doi.org/10.18565/aig.2025.211

Keywords

borderline ovarian tumors
organ-preserving treatment
fertility
UGOWR
ART
Full text (in Russian)

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Received 06.08.2025

Accepted 03.09.2025

About the Authors

Anna A. Petrozhitskaya, obstetrician-gynecologist, oncologist, Researcher at the Oncology Department of Surgical Methods of Treatment, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 117997, Moscow, Russia, Ac. Oparina str., 4, +7(926)257-27-54,
a_petrozhitskaya@oparina4.ru, https://orcid.org/0000-0001-9026-8331
Roman K. Tandelov, Researcher at the Oncology Department of Surgical Methods of Treatment, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 117997, Moscow, Russia, Ac. Oparina str., 4, r_tandelov@oparina4.ru, https://orcid.org/0009-0005-8135-5165
Bova B. Bendzhenova, oncologist, PhD student at the Oncology Department of Surgical Methods of Treatment, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 117997, Moscow, Russia, Ac. Oparina str., 4, b_bendzhenova@oparina4.ru,
https://orcid.org/0009-0004-4744-0422
Konstantin Yu. Morkhov, PhD, oncologist, Head of the Oncology Department of Surgical Methods of Treatment, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 117997, Moscow, Russia, Ac. Oparina str., 4, k_morhov@oparina4.ru,
https://orcid.org/0000-0001-7985-9050
Yana O. Martirosyan, PhD, obstetrician-gynecologist, Researcher at the F. Paulsen Research and Educational Center for ART with the Clinical Department,
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia,
117997, Moscow, Russia, Ac. Oparina str., 4, marti-yana@yandex.ru, https://orcid.org/0000-0002-9304-4410
Almina M. Biryukova, PhD, obstetrician-gynecologist, Clinical Supervisor at the F. Paulsen Research and Educational Center for ART with the Clinical Department,
V Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia,
117997, Moscow, Russia, Ac. Oparina str., 4, a_birukova@oparina4.ru
Corresponding author: Anna A. Petrozhitskaya, a_petrozhitskaya@oparina4.ru

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