The value of folates for child health and development

Narogan M.V., Lazareva V.V., Ryumina I.I., Vedikhina I.A.

1) Academician V. I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia; 2) I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia, Moscow, Russia
The literature review describes a modern view on the metabolism of folates and folic acid in the human body and their role in the development of a child. It presents studies used to diagnose folate deficiency. The authors discuss the sequelae of folate deficiency and folic acid excess in pregnant women and newborn infants. They analyze data on the folate status of premature babies. Existing studies show that there is no risk of folate deficiency in premature infants receiving the current feeding regimens, and uncontrolled additional prescription of folic acid can lead to its excessive intake and excessive blood concentrations in premature infants.

Keywords

folate
folic acid
fetus
premature infants

References

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Reseived 25.02.2019

Accepted 19.04.2019

About the Authors

Narogan Marina Viktorovna, MD, Leading Researcher, Department of Pathology of Newborn and Premature Infants, Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia; Professor, Department of Neonatology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia; ORCID 0000-0002-3160-905X
E-mail: m_narogan@oparina4.ru. 4, Academician Oparin St., Moscow 117997, Russia; 8, Trubetskaya St., Build. 2, Moscow 119991
Lazareva Valentina Vladimirovna, Postgraduate Student, Department of Neonatology, I.M. Sechenov First Moscow State Medical University (Sechenov University),
Ministry of Health of Russia. E-mail: l_tifi@mail.ru 8, Trubetskaya St., Build. 2, Moscow 119991
Ryumina Irina Ivanovna, MD, Head, Department of Pathology of Newborn and Premature Infants, Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia. ORCID 0000-0003-1831-887X
E-mail: i_ryumina@oparina4.ru 4, Academician Oparin St., Moscow 117997, Russia
Vedikhina Irina Aleksandrovna, Biologist, Clinical Diagnostic Laboratory, Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia E-mail: i_vedikhina@oparina4.ru 4, Academician Oparin St., Moscow 117997, Russia

For citation: Narogan M.V., Lazareva V.V., Ryumina I.I., Vedikhina I.A. The value of folates for child health and development.
Akusherstvo i Ginekologiya/ Obstetrics and gynecology. 2019; 8:46-52 (in Russian).
https://dx.doi.org/10.18565/aig.2019.8.46-52

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