Clinical significance of placental lesions
To analyze the data available in the literature on the causes of placental lesions and their role in the development of fetal and maternal complications. The paper gives literature data on major vascular disorders and inflammatory changes in the placenta. The vascular disorders are divided into two subgroups: maternal blood flow disorders and fetal blood flow disorders. The paper presents the characteristics of histological changes in blood vessels and villous lesions in the placenta, which are caused by diminished maternal vascular perfusion and impaired fetal blood flow. It is emphasized that the exact location of a lesion, as well as the form, stage, and degree of inflammation should be indicated when placental inflammatory and immune processes are identified. Morphologically detected placental lesions are noted to be of clinical significance for the mother and fetus, which include fetal growth restriction, intrauterine fetal death, preterm labor, brain injuries, fetal respiratory distress syndrome, necrotizing enterocolitis, and congenital anomalies in a newborn baby.Shchegolev A.I., Serov V.N.
Keywords
placenta
placental abruption
villitis
chorioamnionitis
pregnancy complications
fetus
newborn infant
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Received 19.02.2019
Accepted 22.02.2019
About the Authors
Shchegolev, Aleksandr I., MD, professor, head of the Department of Morbid Anatomy, National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel: +74955314444. E-mail: ashegolev@oparina4.ruSerov, Vladimir N., MD, professor, academician of the Russian Academy of Sciences, chief researcher, National Medical Research Center of Obstetrics, Gynecology,
and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Тel.: +74954387287. E.mail: v_serov@oparina4.ru
For citation: Shchegolev A.I., Serov V.N. Clinical significance of placental lesions. Akusherstvo i Ginekologiya/Obstetrics and Gynecology.2019; (3): 54-62. (in Russian)
https://dx.doi.org/10.18565/aig.2019.3.54-62