Mirror syndrome in the presence of fetofetal transfusion syndrome

Kostyukov K.V., Gladkova K.A., Sakalo V.A., Tetruashvili N.K., Gus A.I., Pyregov A.V., Shmakov R.G.

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow 117997, Ac. Oparina str. 4, Russia
Background. Mirror syndrome is a rare complication with an adverse pregnancy outcome to both the mother and the fetus. The authors give the data available in the literature and their own clinical cases that demonstrate diagnostic methods, management tactics, and a pregnancy outcome in mirror syndrome resulting from fetofetal transfusion syndrome (FFTS).
Case report. Two clinical cases of mirror syndrome in multiple pregnancy complicated by FFTS are analyzed.
Conclusion. In FFTS, there is a risk for mirror syndrome that is accompanied by a high rate of maternal and perinatal complications. The timely treatment of FFTS or termination of pregnancy after failure of treatment can prevent severe obstetric complications.

Keywords

mirror syndrome
Ballantyne syndrome
fetofetal transfusion syndrome
multiple pregnancy
monochorionic twins
ultrasound diagnosis
prenatal diagnosis

References

1. Braun T., Brauer M., Fuchs I., Czernik C., Dudenhausen J.W., Henrich W., Sarioglu N. Mirror syndrome: a systematic review of fetal associated conditions, maternal presentation and perinatal outcome. Fetal Diagn. Ther. 2010; 27(4): 191-203.

2. Dunn P.M. Dr John Ballantyne (1861–1923): perinatologist extraordinary of Edinburgh. Arch. Dis. Child. 1993; 68: 66-7.

3. Brochot C., Collinet P., Provost N., Subtil D. Mirror syndrome due to parvovirus B19 hydrops complicated by severe maternal pulmonary effusion. Prenat. Diagn. 2006; 26(2): 179-80.

4. Matsubara M., Nakata M., Murata S., Miwa I., Sumie M., Sugino N. Resolution of mirror syndrome after successful fetoscopic laser photocoagulation of communicating placental vessels in severe twin–twin transfusion syndrome. Prenat. Diagn. 2008; 28(12): 1167-8.

5. Ordorica S.A., Marks F., Frieden F.J., Hoskins I.A., Young B.K. Aneurysm of the vein of Galen: a new cause for Ballantyne syndrome. Am. J. Obstet. Gynecol. 1990; 162(5): 1166-7.

6. Finamore P.S., Kontopoulos E., Price M., Giannina G., Smulian J.C. Mirror syndrome associated with sacrococcygeal teratoma: a case report. J. Reprod. Med. 2007; 52(3): 225-7.

7. Dorman S.L., Cardwell M.S. Ballantyne syndrome caused by a large placental chorioangioma. Am. J. Obstet. Gynecol. 1995; 173(5): 1632-3.

8. Midgley D.Y., Harding K. The Mirror syndrome. Eur. J. Obstet. Gynecol. Reprod. Biol. 2000; 88(2): 201-2.

9. Ville Y., de Gayffier A., Brivet F., Leruez M., Marchal P., Morinet F. et al. Fetal-maternal hydrops syndrome in human parvovirus infection. Fetal Diagn. Ther. 1995; 10(3): 204-6.

10. Ambrosini G., Nanhorngue K., Pascoli I., Cester M., Cosmi E. Mirror syndrome due to Coxsackie B virus associated to maternal peripartum cardiomyopathy. J. Perinat. Med. 2008; 36(5): 453-4.

11. Chaoui R., Bollmann R., Hoffmann H., Zienert A., Bartho S. Ebstein anomaly as a rare cause of a non-immunological fetal hydrops: prenatal diagnosis using Doppler echocardiography. Klin. Pädiatr. 1990; 202(3): 173-5.

12. Савельева Г.М., Сухих Г.Т., Серов В.Н., Радзинский В.Е., ред. Акушерство. Национальное руководство. М.: ГЭОТАР-Медиа; 2015. 1122с. [Savelyeva G.M., Sukhikh G.T., Serov V.N., Radzinsky V.E., ed. Obstetrics. National guideline. Moscow: GEOTAR-Media; 2015. 1122p. (in Russian)]

13. Веропотвелян Н.П., Ошовский В.И., Бондаренко А.А., Гладкая О.Н., Усенко Т.В. Редкий случай материнского зеркального синдрома при неиммунной водянке плода, вызванной аномалией сосудов пуповины. Пренатальная диагностика. 2014; 13(4): 339-46. [Veropotvelyan N.P., Oshovskiy V.I., Bondarenko A.A., Gladkaya O.N., Usenko Т.V. A rare case of a maternal mirror syndrome in non-immune fetal edema caused by an abnormality of the umbilical cord. Prenatalnaya diagnostika. 2014; 13(4): 339-46. (in Russian)]

14. Айламазян Э.К., Кулаков В.И., Радзинский В.Е., Савельева Г.М., ред. Акушерство. Национальное руководство. М.: ГЭОТАР-Медиа; 2013. 1200с. [Aylamazyan E.K., Kulakov V.I., Radzinsky V.E., Saveleva G.M., ed. Obstetrics. National guideline. Moscow: GEOTAR-Media; 2013. 1200p. (in Russian)]

15. Айламазян Э.К., Павлова Н.Г. Изоиммунизация при беременности. СПб.: Издательство Н-Л; 2012. [Aylamazyan E.K., Pavlova N.G. Isoimmunization during pregnancy. St. Petersburg: Publisher NL; 2012. (in Russian)]

16. Simpson L.L. Twin-twin transfusion syndrome. Am. J. Obstet. Gynecol. 2013; 208: 3-18.

17. Chmait R.H., Kontopoulos E.V., Korst L.M., Llanes A., Petisco I., Quintero R.A. Stage-based outcomes of 682 consecutive cases of twin-twin transfusion syndrome treated with laser surgery: the USFetus experience. Am. J. Obstet. Gynecol. 2011; 204(5): 393. e1-6.

18. Prefumo F., Pagani G., Fratelli N., Benigni A., Frusca T. Increased concentrations of antiangiogenic factors in mirror syndrome complicating twin-to-twin transfusion syndrome. Prenat. Diagn. 2010; 30(4): 378-9.

19. Espinoza J., Romero R., Nien J.K., Kusanovic J.P., Richani K., Gomez R. et al. A role of the anti-angiogenic factor sVEGFR-1 in the ‘mirror syndrome’ (Ballantyne’s syndrome). J. Matern. Fetal Neonatal Med. 2006; 19(10): 607-13.

20. Lobato G., Nakamura-Pereira M. Reversion of the Ballantyne syndrome despite fetal hydrops persistence. Fetal Diagn. Ther. 2008; 24(4): 474-7.

21. Kusanovic J.P., Romero R., Espinoza J., Nien J.K., Kim C.J., Mittal P. et al. Twin-to-twin transfusion syndrome: an antiangiogenic state? Am. J. Obstet. Gynecol. 2008; 198(4): 382. e1-8.

22. Pirhonen J.P., Hartgill T.W. Spontaneous reversal of mirror syndrome in a twin pregnancy after a single fetal death. Eur. J. Obstet. Gynecol. Reprod. Biol. 2004; 116(1): 106-7.

23. Zhao Y., Liu G., Wang J., Yang J., Shen D., Zhang X. Mirror syndrome in a Chinese hospital: diverse causes and maternal fetal features. J. Matern. Fetal Neonatal Med. 2013; 26(3): 254-8.

Received 03.02.2017

Accepted 17.02.2017

About the Authors

Kostyukov Kirill V., MD, doctor of the Department of the Functional Diagnosis, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79262149784. E-mail: k_kostykov@oparina4.ru
Gladkova Kristina A., MD, senior researcher of the Department of Pregnancy Loss Prevention and Therapy, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79163211007. E-mail: k_gladkova@oparina4.ru
Sakalo Viktoria A., clinical resident, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79295887208. E-mail: v_sakalo@oparina4.ru
Tetruashvili Nana K., MD, PhD, Head of the Department of Pregnancy Loss Prevention and Therapy, Research Center of Obstetrics, Gynecology and Perinatology,
Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954381477. E-mail: tetrauly@mail.ru
Gus Alexander I., MD, PhD, Head of the the Department of the Functional Diagnosis, Research Center of Obstetrics, Gynecology and Perinatology,
Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954381177. E-mail: a_gus@oparina4.ru
Pyregov Aleksey V., MD, PhD, Head of the Department of Anesthesiology and intensive care, Research Center of Obstetrics, Gynecology and Perinatology,
Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954383310. E-mail: a_pyregov@oparina4.ru
Shmakov Roman G., MD, PhD, the Chief physician, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954387200. E-mail: r_shmakov@oparina4.ru

For citations: Kostyukov K.V., Gladkova K.A., Sakalo V.A., Tetruashvili N.K., Gus A.I., Pyregov A.V., Shmakov R.G. Mirror syndrome in the presence of fetofetal transfusion syndrome. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (11): 176-80. (in Russian)
https://dx.doi.org/10.18565/aig.2017.11.176-180

Similar Articles

By continuing to use our site, you consent to the processing of cookies that ensure the proper functioning of the site.