Assisted reproductive technologies in married couples at high risk for genetic disorders. Preimplantation genetic screening

Kulakova E.V., Kalinina E.A., Trofimov D.Yu., Makarova N.P., Khechumyan L.R., Dudarova A.Kh.

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow 117997, Ac. Oparina str. 4, Russia
Objective. To carry out a systematic analysis of the data available in the current literature on the role of preimplantation genetic screening (PGS) in the effectiveness of assisted reproductive technology (ART) programs.
Material and methods. The review includes the data of foreign and Russian articles published in the past 10 years and found in Pubmed on this topic.
Results. The paper describes current methods for GS, indications for the latter, as well as the clinical effectiveness of IVF programs with PGS.
Conclusion. The data on the effectiveness of PGS are presently controversial. According to the Cochrane systematic review, there is no strong evidence that PGS is effective in increasing live birth rates. The data on PGS use in men with impaired spermatogenesis are also uncertain. However, PGS is increasingly being used in IVF clinics, by leaning on the opposite points of view that whatever PGS procedure is performed, its application increases embryo implantation rates and reduces the risk of spontaneous abortions, thereby enhancing the effectiveness of ART programs and increasing the chance of having a healthy baby.

Keywords

preimplantation genetic screening
preimplantation genetic diagnosis
in vitro fertilization
embryo implantation
intracytoplasmic sperm injection

Supplementary Materials

  1. Table. The most frequent monogenic diseases on the territory of Russia (according to the data of the Institute of Human Stem Cells OJSC)

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Received 03.11.2017

Accepted 11.11.2017

About the Authors

Kulakova Elena Vladimirovna, PhD, Senior Researcher of department of assisted reproductive technology in treating sterility, Research Center of Obstetrics,
Gynecology, and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina 4. Tel.: +74954381341. E-mail: evkulakova@mail.ru
Kalinina Elena Anatolievna, MD, Associate Professor, The chief of department of assisted reproductive technology in treating sterility, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina 4. Tel.: +74954381341. E-mail: e_kalinina@oparina4.ru
Trofimov Dmitri Yurievich, PhD, Associate Professor, The chief of department of clinical and molecular genetics, Research Center of Obstetrics, Gynecology,
and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina 4. Tel.: +749543849
Makarova Natalia Petrovna, PhD, Researcher of IVF Department, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina 4. Tel.: +74954387700. E-mail: np_makarova@oparina4.ru
Khechumyan Lusine Robertovna, graduate student of department of assisted reproductive technology in treating sterility, Research Center of Obstetrics, Gynecology,
and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina 4. Tel.: +74954382501. E-mail: khechumyan_l@mail.ru
Dudarova Alina Khasanovna, postgraduate of the department of assisted reproductive technology in infertility treatment, Research Center of Obstetrics, Gynecology,
and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina 4. Tel.: +74954382501. E-mail: kanshaov85@mail.ru

For citations: Kulakova E.V., Kalinina E.A., Trofimov D.Yu., Makarova N.P.,
Khechumyan L.R., Dudarova A.Kh. Assisted reproductive technologies in married
couples at high risk for genetic disorders. Preimplantation genetic screening.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (8): 21-7. (in Russian)
http://dx.doi.org/10.18565/aig.2017.8.21-7

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