Influence of alcohol consumption on the bioelement status of pregnant women in the prenatal period

Marianian A.Yu., Kalkova A.N., Akudovich N.V.

Research Center for Family Health and Human Reproduction Problems, Irkutsk, Russia
The paper analyzes the results of the Russian and foreign studies published in the international databases, which deal with the problems of alcohol consumption in pregnant women and its impact on their bioelement status. To date, a huge amount of clinical and experimental material has been accumulated on the effects of many macro- and microelements on human physiology and pathology, but there are few studies of the effect of alcohol and its metabolites on the body, the bioelement status of pregnant women in particular. Nevertheless, the study results presented in this article indicate an extremely negative effect of alcohol on a pregnant woman, including on her bioelement status. It is also noted that when pregnant women abuse alcohol, they are found to have impairments in all lineages of hematopoiesis, especially those of erythropoiesis.
Conclusion: There are not enough studies on the relationship of the content of bioelements in alcohol consumption to the course of pregnancy, childbirth, fetal development, and neonatal adaptation. In addition, they do not fully cover all aspects of this problem. There is a need for pregravid preparation, that is, to prepare for a favorable pregnancy, and this is primarily to refuse to drink alcohol and to replenish the lack of vital bioelements. The use of drugs that contain various bioelements, the development of diets with an optimized content of micro- and macroelements for pregnant women with an alcoholic history, and the development of special infant formulas will certainly help improve the health of the mother, fetus, and newborns.




  1. World Health Organization. Global status report on alcohol and health. Available at:
  2. Балашова Т.Н., Барбара Л.Б., Исурина Г.Л., Регентова А.Ю., Цветкова Л.А. Изучение влияния информационных материалов на отношение женщин к употреблению алкоголя во время беременности. Вестник Санкт-Петербургского университета. 2012; 12(4): 101-7. [Balashova T.N., Barbara L.B., Isurina G.L., Regentova A.Yu., Tsvetkova L.A. Study of the influence of information materials on women's attitudes towards alcohol consumption dur-ing pregnancy. Vestnik Sankt-Peterburgskogo universiteta/ St. Petersburg University Press. 2012; 12(4): 101-7. (in Russian)].
  3. Marianian A., Atalyan A., Bohora S., Darenskaya M., Grebenkina L., Kolesnikova L., Kolesnikov S., Mikhaylevich I., Protopopova N., Stockett M., Yamaoka Y., Balachova T. The effect of low alcohol consumption during pregnancy on the lipid peroxidation-antioxidant defense system of women, their alcohol-exposed infants, and growth, health, and developmental outcomes. Birth De-fects Res. 2019; 112(1): 40-53.
  4. Subramoney S., Eastman E., Adnams C., Stein D.J., Donald K.A. The early developmental outcomes of prenatal alcohol exposure: A review. Front. Neurol. 2018; 9: 1108.
  5. Popova S., Lange S., Temple V., Poznyak V., Chudley A.E., Burd L. et al. Profile of mothers of children with fetal alcohol spectrum disorder: A population-based study in Canada. Int. J. Environ. Res. Public Health. 2020; 17(21): 7986.
  6. Hoyme H.E., Kalberg W.O., Elliott A.J., Blankenship J., Buckley D., Marais A.S. et al. Updated clinical guidelines for diagnosing fetal alcohol spectrum disorders. Pediatrics. 2016; 138(2): e20154256.
  7. Зобнин Ю.В., Церковникова Г.Ю., Лазарева Ж.М., Флоренсов В.В., Иванова Е.И. Опийная интоксикация и абстинентный синдром у новорожденных. Сибирский медицинский журнал. 2005; 56(7): 43-5. [Zobnin Yu.V., Tserkovnikova G.Yu., Lazareva Z.M., Florensov V.V., Ivanova E.I. The intoxication of opiates and the abstinence syndrome at newborns. Sibirskij medicinskij zhurnal/ Siberian Medical Journal. 2005; 56(7): 43-5. (in Russian)].
  8. Сафина Л.З., Шакирова А.З., Салманидина Д.Р. Фетальный алкогольный синдром и синдром абстиненции у новорожденных. Российский вестник перинатологии и педиатрии. 2016; 61(5): 174-8. [Safina L.Z., Shakirova A.Z., Salmanidina D.R. Fetal alcohol syndrome and abstinence syndrome in newborns. Rossijskij vestnik perinatologii i pediatrii/Russian Bulletin of Perinatology and Pediatrics. 2016; 61(5): 174-8. (in Russian)].–4065–2016–61–5–174–178.
  9. Kolesnikova L.I., Darenskaya M.A., Kolesnikov S.I. Free radical oxidation: A pathophysiologist’s view. Bulletin of Siberian Medicine. 2017; 16(4): 16-29.
  10. Darenskaya M.A., Kolesnikov S.I., Rychkova L.R., Grebenkina L.A., Kolesnikova L.I. Oxidative stress and antioxidant defense parameters in different diseases: Ethnic aspects. Free Rad. Biol. Med. 2018; 120(Suppl. 1): S60.
  11. Kolesnikova L.I., Darenskaya M.A., Grebenkina L.A., Labygina A.V., Suturina L.V., Dolgikh M.I., Shiphineeva T..I, Darzhaev Z.Y., Tsyrenov T.B., Rinchindorzhieva M.P. Activity of lipid peroxidation in infertile women from different populations. Bull. Exp. Biol. Med. 2012; 154(2): 203-5.
  12. Balachova T.N., Isurina G.L., Skitnevskaya L.V., Bard D., Tsvetkova L.A., Volkova E.N. Alcohol consumption among pregnant and non-pregnant women in Russia: evidence for prevention. Acta Biomed. Scientifica. 2018; 3(3): 59-67.
  13. Савченко Т.Н., Дергачева И.А., Агаева М.И. Микронутриенты и беременность. Русский медицинский журнал. Мать и дитя. 2016; 15: 1005-8. [Savchenko T. N., Dergacheva I. A., Agaeva M. I. Micronutrients and pregnan-cy. Russkij medicinskij zhurnal. Mat' i ditya/ Russian Medical Journal Mother and Child. 2016; 15: 1005-8. (in Russian)].
  14. Коденцова В.М., Рисник Д.В. Витаминно-минеральные комплексы для коррекции множественного микронутриентного дефицита. Медицинский совет. 2020; 11: 192-200. [Kodentsova V.M., Risnik D.V. Vitamin and mineral complexes for the correction of multiple micronutrient deficiency. Meditsinskiy sovet/Medical Council. 2020; 11: 192-200. (in Russian)].
  15. Таюпова И.М. К вопросу рационального питания, коррекции микронутриентного статуса, профилактики и лечения дефицита железа у беремен-ных. Вопросы питания. 2015; 84(2): 25-31. [Tayupova I.M. On the issue of rational nutrition, correction of micronutrient status, prevention and treatment of iron deficiency in pregnant women. Voprosy pitaniya/Nutrition issues. 2015; 84(2): 25-31. (in Russian)].
  16. Milman N., Byg K.E., Bergholt T., Eriksen L., Hvas A.M. Body iron and individual iron prophylaxis in pregnancy-should the iron dose be adjusted according to serum ferritin? Ann. Hematol. 2006; 85(9): 567-73.
  17. Zhang F.X., Sliwowska J.H., Weinberg J. Prenatal alcohol exposure and fetal programming: effects on neuroendocrine and immune. Exp. Biol. Med. 2005; 230(6): 376-88.
  18. Полянская И.С. Новая классификация биоэлементов в биоэлементоло-гии. Молочнохозяйственный вестник. 2014; 1: 34-42. [Polyanskaya I.S. New classification of bioelements in bioelementology. Journal "Dairy Bulletin" of the Vologda State Dairy Academy named after N.V. Vereshchagin. 2014; 1(13): 34-42. (in Russian)].
  19. Яковлева Л.М., Михайлова Л.А. Нарушение микробиоценоза и реабсорбции микроэлементов толстой кишки крыс при алкогольной интоксикации. Вестник Чувашского университета. 2012; 3: 541-3. [Yakovleva L.M., Mikhailova L.A. The disturbance of microbiocenosis and the reabsorbtion of microelements in the colon of rats during alcoholic intoxication. Vestnik Chuvashskogo universiteta/ Chuvash University Bulletin. 2012; 3: 541-3. (in Russian)].
  20. Самандаров Н.Ю., Рузиева С., Мирзоева Н., Ганиев Х.А., Махкаманова Б.Х., Давлатова Г.Х., Самандаров А.Ю. Содержаний микроэлементов и макро­элементов в сыворотке крови условиях развития хронической алко-гольной интоксикации. Colloquium-journal. 2019; 24(48): 8-9. [Samandarov N.Yu., Ruzieva S., Mirzoeva N., Ganiev H.A., Mahkamanova B.Kh., Davlatova G.Kh. et al. The content of microelements and macroelements in the blood serum under the conditions of the development of chronic alcohol intoxication. Colloquium-journal. 2019: 1-2. (in Russian)].
  21. Skalny A.V., Skalnaya M.G., Grabeklis A.R., Skalnaya A.A., Tinkov A.A. Zinc deficiency as a mediator of toxic effects of alcohol abuse. Eur. J. Nutr. 2018; 57(7): 2313-22.
  22. Ordak M., Bulska E., Jablonka-Salach K., Luciuk A., Maj-Żurawska M., Matsumoto H. et al. Effect of disturbances of zinc and copper on the physical and mental health status of patients with alcohol dependence. Biol. Trace Elem. Res. 2018; 183(1): 9-15.
  23. Sebastiani G., Borrás-Novell C., Casanova M.A., Pascual T.M., Ferrero M.S., Gómez Roig M.D. et al. The effects of alcohol and drugs of abuse on maternal nutritional profile during pregnancy. Nutrients. 2018; 10(8):1008.
  24. Cogswell M.E., Weisberg P., Spong C. Cigarette smoking, alcohol use and adverse pregnancy outcomes: implications for micronutrient supplementation. J. Nutr. 2003; 133(5, Suppl. 2): 1722S-31S.
  25. Мамонова Л.Г. Современные проблемы питания беременных и кормящих женщин. Вопросы современной педиатрии. 2006; 5(4): 104-6. [Mamonova L.G. Modern problems of nutrition of pregnant and lactating women. Questions of modern pediatrics. 2006; 5(4): 104-6. (in Russian)].
  26. Bjorklund G. The role of zinc and copper in autism spectrum disorders. Acta Neurobiol. Exp. 2013; 73(2): 225-36.
  27. Прасад А.С. Цинк для человека: терапевтическое действие и токсичность. Вопросы биологической, медицинской и фармацевтической химии. 2011; 6: 9-13. [Prasad A.S. Zinc for humans: therapeutic effect and toxicity. Voprosy biologicheskoj, medicinskoj i farmacevticheskoj himii/Questions of biological, medical and pharmaceutical chemistry. 2011; 6: 9-13. (in Russian)].
  28. Таюпова И.М. Витаминный статус при дефиците железа у беременных. Электронный научно-образовательный вестник: здоровье и образование в XXI веке. 2015; 17(6): 11-5. [Tayupova I.M. Vitamin status in iron deficiency in pregnant women. Elektronnyj nauchno-obrazovatel'nyj vestnik: zdorov'e i obrazovanie v XXI veke/Electronic scientific and educational bulletin: health and education in the XXI century. 2015; 17(6): 11-5. (in Russian)].
  29. Стуклов Н.И., Семенова Е.Н. Лечение железодефицитной анемии. Что важнее, эффективность или переносимость? Существует ли оптимальное решение? Журнал международной медицины. 2013; 1(2): 47-55. [Stuklov N.I., Semenova E.N. Treatment of iron deficiency anemia. What is more important, efficiency or portability? Is there an optimal solution? Zhurnal mezhdunarodnoj mediciny/Journal of International Medicine. 2013; 1(2): 47-55. (in Russian)].
  30. Гасанова Б.М., Полина М.Л. Беременность и анемия различного генеза: эффективность дифференцированной тактики. Доктор.Ру. 2020; 19(8): 25-31. [Hasanova B.M., Polina M.L. Pregnancy and anemia of various origins: the effectiveness of differentiated tactics. Doctor.Ru. 2020; 19(8): 25-31. (in Russian)].
  31. Milman N. Prepartum anaemia: prevention and treatment. Ann. Hematol. 2008; 87(12): 949-59.
  32. Петунина Н.А., Гончарова Е.В. Йодный дефицит при беременности. Осложнения со стороны матери и плода.Гинекология. 2016; 18(3): 20-2. [Petunina N.A., Goncharova E.V. Iodine deficiency during pregnancy. Complications from the mother and the fetus. Ginekologiya/Gynecology. 2016; 18(3): 20-2. (in Russian)].
  33. Беспалов В.Г., Туманян И.А. Йод и женское здоровье. Consilium Medicum, 2019; 21(6): 13-21. [Bespalov V.G., Tumanyan I.A. Iodine and Women's Health. Consilium Medicum, 2019; 21(6): 13-21. (in Russian)].
  34. Нечаева М.В., Власова О.В., Пинкина А.С. Влияние йодного дефицита на течение беременности и родов, пути коррекции у женщин города Самары. Известия Самарского научного центра Российской академии наук. 2011; 13(7): 1631-3. [Nechaeva M.V., Vlasova O.V., Pinkina A.S. Influence of iodic deficiency on the current of pregnancy and sorts, ways of correction at women from Samara city. Izvestiya Samarskogo nauchnogo centra Rossijskoj akademii nauk/Bulletin of the Samara Scientific Center of the Russian Academy of Sciences. 2011; 13(7): 1631-3. (in Russian)].
  35. Абдулхабирова Ф.М. Йододефицитные состояния во время беременности. Consilium Medicum. 2016; 18(6): 43-5. [Abdulhabirova F.M. Iodine deficiency during pregnancy. Pregnancy pathology. 2016; 18(6): 43-5. (in Russian)].
  36. Софронов В.В., Волошин А.В., Скворцова Г.Ш. Особенности содержания хрома, марганца, меди и цинка в плазме и эритроцитах у матерей и их новорожденных при угрозе прерывания беременности в анамнезе. Российский вестник перинатологии и педиатрии. 2020; 65(4): 61-6. [Sofronov V.V., Voloshyn A.V., Skvortsova G.S. The content of chromium, manganese, copper and zinc in plasma and red blood cells in mothers and their newborns with a threatened pregnancy in the anamnesis. Rossiyskiy Vestnik Perinatologii i Pediatrii/Russian Bulletin of Perinatology and Pediatrics. (in Russian)].
  37. Grober U., Schmidt J., Kisters K. Magnesium in prevention and therapy. Nutrients. 2015; 7(9): 8199-226.
  38. Дадак К., Макацария А.Д., Блинов Д.В., Зимовина У.В. Клинические и биохимические аспекты применения препаратов магния в акушерстве, гинекологии и перинатологии. Акушерство, гинекология и репродукция. 2014; 8(2): 69-78. [Dadak K., Makatsaria A.D., Blinov D.V., Zimovina U.V. Clinical and biochemical aspects of the use of magnesium preparations in ob-stetrics, gynecology and perinatology. Akusherstvo, ginekologiya i reprodukciya/Obstetrics, gynecology and reproduction. 2014; 8(2): 69-78. (in Russian)].
  39. Балан В.Е., Журавель А.С., Тихомирова Е.В., Панина Е.М., Овчинникова В.В. Современный взгляд на необходимость коррекции дефицита магния при беременности. Медицинский совет. 2017; 20: 198-202. [Balan V.E., Zhuravel A.S., Tikhomirova E.V., Panina E.M., Ovchinnikova V.V. The modern view on the need to correct magnesium deficiency during pregnancy. Medicinskij sovet/Medical Council. 2017; 20: 198-202. (in Russian)].
  40. Селихова М.С., Смольянинов А.А., Калачева Л.С. Репродуктивное здоровье женщины и дефицит магния. Вестник Волгоградского государствеyного медицинского университета ("Вестник ВолгГМУ"). 2019; 4: 3-7. [Selikhova M.S., Smolyaninov A.A., Kalacheva L.S. Women's reproductive health and magnesium deficiency. Vestnik Volgogradskogo gosudarstvennogo medicinskogo universiteta ("Vestnik VolgGMU")/Bulletin of the Volgograd State Medical University. 2019; 4(72): 3-7. (in Russian)].
  41. Щербавская Э.А., Гельцер Б.И. Обмен кальция и метаболизм костной ткани при беременности. Остеопороз и остеопатии. 2002; 2: 1-4. [Shcherbavskaya E.A., Geltser B.I. Calcium metabolism and bone metabolism during pregnancy. Osteoporoz i osteopatii /Osteoporosis and Osteopathy 2002; 2: 1-4. (in Russian)].
  42. Baran D.T., Bryant C., Robson D. Alcohol-induced alterations in calcium metabolism in the pregnant rat. Am. J. Clin. Nutr. 1982; 36(1): 41-4.
  43. Marianian A.Y., Kolesnikova L.I., Protopopova N.V., Burina E.A., Kalinkina O.B. Influence of small doses of alcohol on the stateof healthof pregnant women and their newborns. Alcoholism: Clinical and Experimental Research. 2018; 42(6): 77.
  44. Шелепова Е.С., Зазерская И.Е., Хазова Е.Л., Кузнецова Л.В., Яковлева Н.Ю., Васильева Е.Ю. Особенности обмена кальция при беременности в зависимости от насыщенности организма витамином D. Гинекология. 2016; 18(2): 8-10. [Shelepova E.S., Zazerskaya I.E., Khazova E.L., Kuz-netsova L.V., Yakovleva N.Yu., Vasilieva E.Yu. Features of calcium metabolism during pregnancy, depending on the saturation of the body with vitamin D. Ginekologiya/Gynecology. 2016; 18(2): 8-10. (in Russian)].

Received 31.05.2021

Accepted 02.07.2021

About the Authors

Anait Yu. Marianian, MD, PhD, Head of the Laboratory of Socially Important Problems of Reproductology, Leading Researcher of Scientific Centre
for Family Health and Human Reproduction Problems (SC FHHRP); Associate Professor of the Department of Obstetrics and Gynecology,
ISMAPGE – Branch of the RMACPE MOH, +7(3952)20-76-36; +7(914)014-70-65,;,
664003, Russia, Irkutsk, Timiryazev str., 16.
Anastasia N. Kalkova, clinical resident and laboratory researcher of the Laboratory of Socially Important Problems of Reproductology, Scientific Centre for Family Health and Human Reproduction Problems (SC FHHRP), +7(902)576-00-19,, 664003, Russia, Irkutsk, Timiryazev str., 16.
Natalya V. Akudovich, MD, PhD, obstetrician-gynecologist, laboratory assistant-researcher of the Laboratory of Socially Important Problems of Reproductology, Scientific Centre for Family Health and Human Reproduction Problems (SC FHHRP); Assistant of the Department of Obstetrics and Gynecology, Irkutsk State Medical University,
+7(3952)20-76-36,;,, 664003, Russia, Irkutsk, Timiryazev str., 16.
Corresponding author: Anait Yu. Marianian,

Authors' contributions: Marianian A.Yu., Kalkova A.N. – concept and design of the investigation; Kalkova A.N., Akudovich N.V. – material collection and processing; literary search for Russian and foreign studies in Russian and international databases; Marianian A.Yu., Kalkova A.N., Akudovich N.V. – analysis of the data of published studies; writing the text; Marianian A.Yu. – editing.
Conflicts of interest: The authors declare that there are no possible conflicts of interest.
Funding: The investigation was conducted within the framework of the state budget topic and fundamental researches since 2021.
For citation: Marianian A.Yu., Kalkova A.N., Akudovich N.V. Influence of alcohol consumption on the bioelement status of pregnant women in the prenatal period.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2021; 10: 21-30 (in Russian)

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