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Obstetrics and Gynegology2021№8
Vitamins and trace elements in...

Vitamins and trace elements in the prevention of infectious diseases in women of reproductive age

DOI
https://dx.doi.org/10.18565/aig.2021.8.220-228

Shikh E.V., Makhova A.A., Prokofiev A.B., Nazarchuk A.S.

1) I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia, Moscow, Russia; 2) Center for Clinical Pharmacology, Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Health of Russia, Moscow, Russia
The issue of increasing nonspecific immunity is becoming particularly relevant in the context of the spread of a new coronavirus infection SARS-CoV-2. Thus, there is question of supplementation with vitamins and micronutrients, especially in reproductive-aged women planning pregnancy, due to socio-economic aspects, geographical latitude, dietary habits, and increased needs associated with the epidemiological situation. The deficiency of certain micronutrients in the diet has been found to impair the chemical, structural and regulatory processes in the body, which can negatively affect the state of the immune system. Certain associations have been identified between sufficiency of micronutrients, the severity of the course and development of complications of COVID-19. Severe course of infection is associated with severe deficiency of vitamin D (<10 ng/ml). Vitamin D contributes to changing the macrophage phenotype from pro-inflammatory Th1 to anti-inflammatory Th2, which may reduce the risk of a cytokine storm. There was a statistically significant decrease in the level of inflammatory markers, including ferritin and D-dimer, a decrease in the risks of multiple organ failure, a tendency to reduce the need for ventilation, vascular damage in patients with acute respiratory distress syndrome with parenteral use of high doses of ascorbic acid. The experimental studies have shown that cations Zn2+ inhibit the activity of SARS-coronavirus RNA polymerase by reducing its replication; this fact opens up prospects for the use of Zn2+ as an antiviral agent in the treatment of COVID-19. Vitamin E and selenium have effects that reduce the risk of infection: they increase the number of T cells, enhance the responses of mitogenic lymphocytes, increase the secretion of IL-2 cytokines, and stimulate the activity of natural killer cells. The causative agent influences beta-carotene which accelerates the immune response of the body by increasing the activity of macrophages. Conclusion. The strategies for the prevention of COVID-19 provide for the intake of vitamin and mineral complexes containing vitamins D, A, E, zinc, selenium. The optimal intake of micronutrients largely determines the protection of a person from the effects of negative environmental factors including biological agents, namely microbes and viruses.

Keywords

COVID-19
prevention
nonspecific resistance
vitamins
trace elements
Full text (in Russian)

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Received 03.08.2021

Accepted 11.08.2021

About the Authors

Evgenia V. Shikh, Dr. Med. Sci., Professor, Head of the Department of Clinical Pharmacology and Propaedeutics of Internal Diseases, I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University). Tel.: +7(495)609-19-91. E-mail: chih@mail.ru. ORCHID: 0000-0001-6589-7654.
119991, Russia, Moscow, Trubetskaya str., 8-2.
Anna A. Makhova, Dr. Med. Sci., Associate Professor of the Department of Clinical Pharmacology and Propaedeutics of Internal Diseases, I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University). Tel.: +7(495)609-19-91. E-mail: annabramova@gmail.com.
ORCHID: 0000-0001-9817-9886. 119991, Russia, Moscow, Trubetskaya str., 8-2.
Alexey B. Prokofiev, Dr. Med. Sci., Professor, Director of the Center for Clinical Pharmacology of the Scientific Centre for Expert Evaluation of Medicinal Products, Ministry
of Health of Russia. Tel.: +7(495)121-06-00 (ex. 6375). E-mail: prokofyev56@gmail.com. ORCHID: 0000-0001-7024-5546. 127051, Russia, Moscow, Petrovsky Boulevard, 8-2.
Anastasiia S. Nazarchuk, student, I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University).
Tel.: +7(915)530-01-29. E-mail: nazarchuk_a_s@student.sechenov.ru. ORCID: 0000-0002-5000-2771. 119991, Russia, Moscow, Trubetskaya str., 8-2

For citation: Shikh E.V., Makhova A.A., Prokofiev A.B., Nazarchuk A.S. Vitamins and trace elements in the prevention of infectious diseases in women of reproductive age.
Akusherstvo i Ginekologiya / Obstetrics and gynecology. 2021; 8: 220-228 (in Russian)
https://dx.doi.org/10.18565/aig.2021.8.220-228

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