A successful outcome of in vitro fertilization in absolute teratozoospermia after spermatozoon selection by the zeta potential
Modern sperm selection methods have not been widely applied in embryological practice, which is primarily associated with the insufficient volume of the documentary basis on their effectiveness. Sperm selection by the zeta potential is one of few methods, the clinical results of which have been published in the world literature.Gamidova P.S., Makarova N.P., Smolnikova V.Yu., Lobanova N.N.
Case report: This paper describes a clinical case of the in vitro fertilization protocol with sperm selection by the zeta potential in a couple with a history of few unsuccessful attempts to use assisted reproductive technologies (ART). The main cause of infertility in the couple was absolute teratozoospermia (0% of morphologically intact spermatozoa by Kruger’s strict criteria). After intracytoplasmatic injection of the sperm selected by the zeta potential into the oocytes, seven normal zygotes formed; three embryos developed; two embryos were cryo-preserved, and one embryo was transferred into the uterine cavity with the subsequent onset of pregnancy that resulted in the birth of a baby.
Conclusion: Sperm selection by the zeta potential and other studied methods for selecting male gametes deserve more active use in the ART protocols, especially in couples with repeated implantation failures. The experience gained in this way will be able to choose the most effective methods, to formulate indications for each of them, and provide a rationale their application in the context of evidence-based medicine.
Authors' contributions: Gamidova P.S. – collection and analysis of literary data, processing and analysis of source material, article writing; Makarova N.P. – collection and analysis of literary data, manuscript editing; Smolnikova V.Yu. – manuscript editing, critical analysis; Lobanova N.N. – analysis of literary sources, article reviewing.
Conflicts of interest: The authors declare that there are no possible conflicts of interest.
Funding: The investigation was conducted without additional third-party funding.
Patient Consent for Publication: The female patient has signed an informed consent form to the publication of her data.
For citation: Gamidova P.S., Makarova N.P., Smolnikova V.Yu., Lobanova N.N.
A successful outcome of in vitro fertilization in absolute teratozoospermia after
spermatozoon selection by the zeta potential.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2023; (6): 155-159 (in Russian)
https://dx.doi.org/10.18565/aig.2023.29
Keywords
teratozoospermia
sperm selection
in vitro fertilization (IVF)
zeta potential
pregnancy
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Received 01.02.2023
Accepted 04.05.2023
About the Authors
Gamidova Parvin Safail kizi, PhD student, Department of IVF named after Professor B.V. Leonov, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation, gamidova.parvina@yandex.ru, 117997, Russia, Moscow, Academician Oparin str., 4.Natalya P. Makarova, Dr. Bio. Sci., Leading Researcher, Department of IVF named after Professor B.V. Leonov, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation, np_makarova@oparina4.ru,
117997, Russia, Moscow, Academician Oparin str., 4.
Veronika Yu. Smolnikova, Dr. Med. Sci., Leading Researcher, Department of IVF named after Professor B.V. Leonov, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation, v_smolnikova@oparina4.ru,
117997, Russia, Moscow, Academician Oparin str., 4.
Natalia N. Lobanova, Junior Researcher, Department of IVF named after Professor B.V. Leonov, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation, n_lobanova@oparina4.ru, 117997, Russia, Moscow, Academician Oparin str., 4.
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