Successful pregnancy outcome of nonimmune hydrops fetalis due to parvovirus B19
Background. Parvovirus B19 infection during pregnancy can lead to nonimmune hydrops fetalis (NIHF), a condition characterized by a high perinatal mortality.Kadyrberdieva F.Z., Tetruashvili N.K., Shmakov R.G., Bokeria E.L., Kostyukov K.V., Kim L.V., Bystrykh O.A., Donnikov A.E., Podurovskaya Y.L.
Clinical case report. The paper describes a clinical case of NIHF caused by parvovirus B19 with a favorable outcome during treatment. The main therapeutic methods for antenatal exposure, which include drug and fetal surgical treatments, are depicted. The applied integrated approach could not only prolong pregnancy to full term, but also led to a significant intrauterine reversal of NIHF phenomena.
Conclusion. This clinical case demonstrates the need for further study of the problem of NIHF and for the selection of therapeutic measures based on the determination of an etiological factor. Such an approach contributes to the selection of optimal management tactics for pregnancy, delivery, and neonatal care.
Keywords
nonimmune hydrops fetalis
ascites
hydrothorax
parvovirus B19
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Received 27.11.2019
Accepted 29.11.2019
About the Authors
Faina Z. Kadyrberdieva, postgraduate student, National Medical Research Center of Obstetrics, Gynecology and Perinatology named after Acad. V.I. Kulakov, Ministry of Health of Russia. Tel.: +79099165852. E-mail: f_kadyrberdieva@oparina4.ruMoscow 117997, Ac. Oparina str. 4, Russia.
Nana K. Tetruashvili, MD, head of the department of pregnancy loss prevention and therapy, National Medical Research Center of Obstetrics, Gynecology and Perinatology named after Acad. V.I. Kulakov, Ministry of Health of Russia. Tel.: +74954381477. E-mail: n_tetruashvili@oparina4.ru
Moscow 117997, Ac. Oparina str. 4, Russia.
Roman G. Shmakov, MD, professor of the Russian Academy of Sciences, National Medical Research Center of Obstetrics, Gynecology and Perinatology named
after Acad. V.I. Kulakov, Ministry of Health of Russia. Tel.: +74954387200. E-mail: r_shmakov@oparina4.ru
Moscow 117997, Ac. Oparina str. 4, Russia.
Ekaterina L. Bokeriya, MD, professor, head of the department of pathology of newborn and premature babies, National Medical Research Center of Obstetrics, Gynecology and Perinatology named after Acad. V.I. Kulakov, Ministry of Health of Russia/ Moscow 117997, Ac. Oparina str. 4, Russia. Tel.: +74954382705. E-mail: e_bokeriya@oparina4.ru
Kirill V. Kostyukov, PhD, doctor of the department of the functional diagnosis, National Medical Research Center of Obstetrics, Gynecology and Perinatology named after Acad. V.I. Kulakov, Ministry of Health of Russia, Moscow 117997, Ac. Oparina str. 4, Russia. Tel.: +74954382529. E-mail: k_kostyukov@oparina4.ru
Lydmila V. Kim, PhD, doctor of the department of pregnancy loss prevention and therapy, National Medical Research Center of Obstetrics, Gynecology and Perinatology named after Acad. V.I. Kulakov, Ministry of Health of Russia, Moscow 117997, Ac. Oparina str. 4, Russia. Tel.: +74954381477. E-mail: l_kim@oparina4.ru
Oksana A. Bystrykh, PhD, head of the department of transfusion immunology and blood preparation, National Medical Research Center of Obstetrics, Gynecology and Perinatology named after Acad. V.I. Kulakov, Ministry of Health of Russia, Moscow 117997, Ac. Oparina str. 4, Russia. Tel.: +74957374814. E-mail: o_bystrykh@oparina4.ru
Andrey E. Donnikov, PhD, head of the laboratory of molecular genetics, National Medical Research Center of Obstetrics, Gynecology and Perinatology named
after Acad. V.I. Kulakov, Ministry of Health of Russia, Moscow 117997, Ac. Oparina str. 4, Russia. Tel.: +74954381477. E-mail: a_donnikov@oparina4.ru
Yuliya L. Podurovskaya, PhD, head of the pediatric surgery department, National Medical Research Center of Obstetrics, Gynecology and Perinatology named
after Acad. V.I. Kulakov, Ministry of Health of Russia, Moscow 117997, Ac. Oparina str. 4, Russia. Tel.: +74954381477. E-mail: y_podurovskaya@oparina4.ru
For citation: Kadyrberdieva F.Z., Tetruashvili N.K., Shmakov R.G., Bokeria E.L., Kostyukov K.V., Kim L.V., Bystrykh O.A., Donnikov A.E., Podurovskaya Y.L. Successful pregnancy outcome of nonimmune hydrops fetalis due to parvovirus B19.
Akusherstvo i Ginekologiya/ Obstetrics and gynecology. 2020; 3: 238-44. (In Russian).
https://dx.doi.org/10.18565/aig.2020.3.238-244
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