Improved approaches in the treatment of complicated bacterial vaginosis and vulvovaginal candidiasis
Objective. To conduct a comparative analysis of the effectiveness of an improved imidazole derivative (2% clotrimazole cream) as part of complex therapy with standard treatment regimens for the development of bacterial vaginosis and vulvovaginal candidiasis.Strizhakov A.N., Ignatko I.V., Churganova A.A., Bogacheva N.A.
Materials and methods. The study included 90 women who had combinations of Atopobium vaginae, Gardnerella vaginalis and Candida krusei. These pathogens caused not only the development of an infectious process in the lower part of the urogenital tract, but also its complicated course.
Results. The study showed that the use of the improved imidazole derivative (2% clotrimazole cream) could arrest the main symptoms of the disease after the first use. The drug is highly effective against difficult-to-cultivate pathogens of bacterial vaginosis and Candida non-albicans, and also does not adversely affect the amount of lactobacilli in vaginal biocenosis.
Conclusion. The experience of using the improved imidazole derivative shows that the drug is no less effective in inflammatory diseases of the lower parts of the urogenital tract than its counterparts. Its purpose is appropriate in the complex therapy of complicated bacterial vaginosis and vulvovaginal candidiasis.
Keywords
bacterial vaginosis
vulvovaginal candidiasis
imidazole derivative
References
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Received 30.11.2018
Accepted 07.12.2018
About the Authors
Strizhakov, Alexander N., MD academician of the Russian Academy of Sciences, professor, head of the Department of Obstetrics, Gynecology and Perinatology, Medical Faculty, I.M. Sechenov First Moscow State Medical University (Sechenov University).119991, Russia, Moscow, Trubetskaya str. 8, bldg. 2. Tel.: +74997823045. E-mail: kafedra-agp@mail.ru. Scopus ID 7005104683
Ignatko, Irina V., MD, corresponding member of the Russian Academy of Sciences, professor of the Department of Obstetrics, Gynecology and Perinatology, Medical Faculty,
I.M. Sechenov First Moscow State Medical University (Sechenov University).
119991, Russia, Moscow, Trubetskaya str. 8, bldg. 2. Tel.: +74997823045. E-mail: iradocent@mail.ru. ORCID 0000-0002-9945-3848. Scopus ID 15118951800
Churganova, Anastasia A., PhD, assistant of the Department of Obstetrics, Gynecology and Perinatology, Medical Faculty, I.M. Sechenov
First Moscow State Medical University (Sechenov University).
119991, Russia, Moscow, Trubetskaya str. 8, bldg. 2.Tel.: +74997823045. E-mail: churganova1@rambler.ru. ORCID 0000–0001-9398-9900. Scopus ID 57194097924
Bogacheva, Natalia A., PhD, assistant of the Department of Obstetrics, Gynecology and Perinatology, Medical Faculty, I.M. Sechenov First Moscow State Medical University (Sechenov University). 119991, Russia, Moscow, Trubetskaya str. 8, bldg. 2. Tel.: +74997823045. E-mail: kafedra-agp@mail.ru
For citations: Strizhakov A.N., Ignatko I.V., Churganova A.A., Bogacheva N.A. Improved approaches in the treatment of complicated bacterial vaginosis and vulvovaginal candidiasis.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (12): 142-8. (in Russian)
http://dx.doi.org/10.18565/aig.2018.12.142-148
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