The levels of interleukin-6, soluble interleukin-6 and vascular endothelial growth factor receptors during delivery at term, threatened preterm labor, and in preeclampsia
Objective. To study of the serum levels of interleukin-6 (IL-6), soluble IL-6 and vascular endothelial growth factor (VEGF) receptors in women during delivery at term, threatened preterm labor, and in preeclampsia.Shcherbakov V.I., Pozdnyakov I.M., Shirinskaya A.V., Volkov M.V.
Subjects and methods. A total of 85 pregnant women who were divided into 4 groups were examined. Group 1 included 35 women with physiological delivery; Group 2 consisted of 11 with threatened preterm labor; Group 3 comprised 23 with preeclampsia; Group 4 (a control group) included 16 with physiological pregnancy. A solid-phase enzyme-linked immunoabsorbent assay was used to determine the serum levels of IL-6, soluble IL-6 and VEGF receptors.
Results. The level of IL-6 was shown to increase dramatically in women with physiological delivery while the level in those with threatened preterm labor was approximately the same as that in the controls. The content of soluble IL-6 receptor was opposite to that of IL-6. The level of soluble VEGF receptor 1 reduced in threatened preterm labor and increases in physiological delivery and preeclampsia.
Keywords
preeclampsia
preterm labor
interleukin-6
soluble receptors
Supplementary Materials
- Fig.1 Interleukine 6 level in the control group, in case of threatened preterm labor, in case of physiologic labor and in case of preeclampsia
- Fig.2 Soluble receptor of interleukine 6 level in the control group, in case of threatened preterm labor, in case of physiologic labor and in case of preeclampsia
- Fig.3 Soluble receptor 1 of epidermal growth factor in the control group, in case of threatened preterm labor, in case of physiologic labor and in case of preeclampsia
- Fig. 4. Potential model explaining myometrium contraction degree in case of physiologic (term) labor and threated preterm labor.
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Received 20.06.2016
Accepted 02.09.2016
About the Authors
Shcherbakov Vladimir Ivanovich, doctor of medical sciences, research fellow of the Immunology Laboratory, Research Institute of Experimental and Clinical Medicine.630117, Russia, Novosibirsk, Timakova str. 2. Tel.: +79137122188. E-mail: Shcherbakov_VI@mail.ru
Pozdnyakov Ivan Mikhailovich, Doctor of Medical Sciences, Professor of the Department of Obstetrics and Gynecology of Novosibirsk State Medical University,
Ministry of Health of Russia; Chief Physician of Novosibirsk City Clinical Perinatal Center. 630091, Russia, Novosibirsk, Krasny pr. 52
Shirinskaya Anna Vladimirovna, obstetrician-gynecologist of Novosibirsk City Clinical Perinatal Center, women’s consultation No. 2.
630089, Russia, Novosibirsk, Adriena Lezhena str. 32. Tel.: +79232341007. E-mail: anncharm2004@mail.ru
Volkov Mikhail Valentinovich, obstetrician-gynecologist, Clinical Maternity Hospital Six, women’s consultation.
630048, Russia, Novosibirsk, Vertkovskaya str. 5. Tel.: +79133918932. E-mail: Michaelis67@mail.ru
For citations: Shcherbakov V.I., Pozdnyakov I.M., Shirinskaya A.V., Volkov M.V. The levels of interleukin-6, soluble interleukin-6 and vascular endothelial growth factor receptors during delivery at term, threatened preterm labor, and in preeclampsia. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (3): 50-4. (in Russian)
http://dx.doi.org/10.18565/aig.2017.3.50-4
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