Plasma miRNA expression levels in women with preeclampsia and chronic arterial hypertension in the first trimester of pregnancy
Semenov Yu.A., Antonov V.N., Azarenkova E.A., Chizhovskaya A.V., Veryaskina Yu.A.
Objective: This study aimed to investigate the expression of several miRNAs in the plasma of patients with chronic arterial hypertension (CAH) without preeclampsia and pregnant women with CAH-associated preeclampsia (CAP) during the first trimester of pregnancy.
Materials and methods: The study included 100 patients: Group 1 (n=58) comprised pregnant women with CAH without preeclampsia, and Group 2 (n=42) included women with CAP. The plasma expression levels of 11 miRNAs were assessed in these patients at 12–14 weeks of gestation using quantitative real-time polymerase chain reaction. Statistical analysis was conducted using the IBM SPSS Statistics software (version 26.0, USA).
Results: Women with CAP exhibited contrasting changes in the expression of five out of 11 plasma miRNAs compared to the group without CAP. The expression levels of miRNA-20a (p<0.001) and miRNA-181a (p<0.001) were significantly decreased in the CAP group. Conversely, the expression levels of miRNA-221 (p<0.001), miRNA-146a (p=0.02), and miRNA-210 (p=0.041) were higher in this group than in women who did not develop preeclampsia.
Conclusion: Statistically significant changes in the expression levels of several miRNAs associated with cardiovascular pathology and placental dysfunction were identified in the first trimester of pregnancy in patients with CAH and CAP.
Authors' contributions: Semenov Yu.A., Antonov V.N. – conception and design of the study, editing of the manuscript; Veryaskina Yu.A. – data collection and processing; Azarenkova E.A., Chizhovskaya A.V. – statistical analysis and drafting of the manuscript.
Conflicts of interest: The authors have no conflicts of interest to declare.
Funding: There was no funding for this study.
Ethical approval: The study was reviewed and approved by the Research Ethics Committee of the Ural Research Institute for Maternity and Child Care.
Patient Consent for Publication: All patients provided informed consent for the publication of their data.
Authors' Data Sharing Statement: The data supporting the findings of this study are available upon request from the corresponding author after approval from the principal investigator.
For citation: Semenov Yu.A., Antonov V.N., Azarenkova E.A., Chizhovskaya A.V., Veryaskina Yu.A. Plasma miRNA expression levels in women with preeclampsia and chronic arterial hypertension in the first trimester of pregnancy.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2025; (10): 90-96 (in Russian)
https://dx.doi.org/10.18565/aig.2025.215
Keywords
References
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Received 12.08.2025
Accepted 01.09.2025
About the Authors
Yurii A. Semenov, Dr. Med. Sci., Associate Professor, Director, Ural Research Institute for Maternal and Child Health, Ministry of Health of the Russian Federation,620028, Russia, Yekaterinburg, Repin str., 1, +7(904)815-62-46, u-sirius@mail.ru, https://orcid.org/0000-0002-3268-7981
Vladimir N. Antonov, Dr. Med. Sci., Associate Professor, Professor at the Therapy Department of the Institute of Continuing Professional Education,
South Ural State Medical University, Ministry of Health of the Russian Federation, 454092, Russia, Chelyabinsk, Vorovskogo str., 64, +7(919)357-04-73, ant-vn@yandex.ru, https://orcid.org/0000-0002-3531-3491
Evgeniia A. Azarenkova, Head of the Educational and Methodological Department, Ural Research Institute for Maternal and Child Health, Ministry of Health of the Russian Federation, 620028 Russia, Yekaterinburg, Repin str., 1, +7(908)581-51-86, jennysplean@mail.ru, https://orcid.org/0000-0001-9656-350X
Anna V. Chizhovskaya, Deputy Director for Organizational and Methodological Work and Public Issues, Ural Research Institute for Maternal and Child Health,
Ministry of Health of the Russian Federation, 620028 Russia, Yekaterinburg, Repin str., 1, +7(951)124-60-13, ms.chizhovskaya@mail.ru, https://orcid.org/0000-0003-1574-1613
Yuliya A. Veryaskina, PhD, Researcher at the Laboratory of Molecular Genetics, Department of Chromosome Structure and Function, Institute of Molecular and
Cellular Biology of the Siberian Branch of the Russian Academy of Sciences, 630090, Russia, Novosibirsk, Lavrentiev Ave., 8/2, +7(383)363-90-42, microrna@inbox.ru,
https://orcid.org/0000-0002-3799-9407
Corresponding author: Evgeniia A. Azarenkova, jennysplean@mail.ru



