Thrombocytopenic syndromes during pregnancy

Grandone E., Mingalimov M.A., Grigoryeva K.N., Bitsadze V.O., Shkoda A.S., Khizroeva D.Kh., Vorobyev A.V., Makatsariya A.D.

1) Department for Clinical Trials of Thromboses and Hemostasis, Medical Genetics Clinic Casa Sollievo della Sofferenza, Italy; 2) Obstetrics and Gynecology Department Two, Children’s Health Center, I.M. Sechenov First Moscow State Medical University, Moscow, Russia; 3) L.A. Vorokhobov City Clinical Hospital Sixty-Seven, Moscow Healthcare Department, Moscow, Russia
The authors carried out a systematic analysis of data on the etiology and pathogenesis of thrombocytopenia-associated conditions during pregnancy. The review includes foreign and Russian articles published over the past 10 years and found in eLibrary and PubMed on this topic. It analyzes data on the most studied and common diseases accompanied by thrombocytopenia during gestation: gestational thrombocytopenia (thrombocytopenia during pregnancy, pseudo-idiopathic thrombocytopenic purpura), immune-mediated thrombocytopenic purpura, preeclampsia, HELLP syndrome, thrombotic thrombocytopenic purpura (Moschcowitz disease), atypical hemolytic uremic syndrome, acute fatty liver of pregnancy, heparin-induced thrombocytopenia, antiphospholipid syndrome, and virus-induced thrombocytopenia. The information obtained will assist in more carefully making a differential diagnosis of the causes of thrombocytopenia in pregnant women and in timely prescribing etiotropic treatment.


gestational thrombocytopenia
pseudo-idiopathic thrombocytopenic purpura
idiopathic thrombocytopenic purpura
thrombotic thrombocytopenic purpura
atypical hemolytic-uremic syndrome
acute fatty liver of pregnancy
heparin-induced thrombocytopenia
antiphospholipid syndrome
virus-induced thrombocytopenia


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Received 03.09.2019

Accepted 04.10.2019

About the Authors

Elvira Grandone, MD, PhD, Head of Unit Clinical and Research In Thrombosis and Haemostasis IRCCS Ospedale Casa Sollievo della Sofferenza, professor of the Department of Obstetrics and Gynecology, The First I.M. Sechenov Moscow State Medical University; email:
Marat A. Mingalimov, student of paediatric faculty of The First I.M. Sechenov Moscow State Medical University; e-mail:
Kristina N. Grigorieva, student of paediatric faculty of The First I.M. Sechenov Moscow State Medical University; email:
Viktoria O. Bitsadze, MD, PhD, Professor of the Russian Academy of Sciences, Professor of the Department of Obstetrics and Gynecology, The First I.M. Sechenov Moscow State Medical University; e-mail:
Andrei S. Skoda, MD, professor, chief physician of the City Clinical Hospital No. 67 named after L.A. Vorokhobov, Moscow Department of Health. Tel .: +7 (495) 530-30-71; e-mail:; 123423, Russia, Moscow, ul. Salam Adil, d. 2/44.
Jamilya Kh. Khizroeva, MD, PhD, Professor of the Department of Obstetrics and Gynecology, The First I.M. Sechenov Moscow State Medical University; E-mail:
Alexander V. Vorobev, MD, PhD, Associate Professor of the Department of Obstetrics and Gynecology, The First I.M. Sechenov Moscow State Medical University;
Aleksander D. Makatsariya, MD, PhD, corresponding member of the Russian Academy of Sciences, Professor, Head of the Department of Obstetrics and Gynecology,
The First I.M. Sechenov Moscow State Medical University; E-mail:

For citation: Grandone E., Mingalimov M.A, Grigoryeva K.N. Bitsadze V.O., Shkoda A.S., Khizroeva D.Kh., Vorobyev A.V., Makatsariya A.D. Thrombocytopenic syndromes during pregnancy.
Akusherstvo i Ginekologiya/ Obstetrics and gynecology. 2019; 10: 5-12. (In Russian).

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