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The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
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Obstetrics and Gynegology2023№10
Vaginal microbiota transplantation

Vaginal microbiota transplantation

DOI
https://dx.doi.org/10.18565/aig.2023.142

Kira E.F., Priputnevich T.V., Muravieva V.V., Khalturina Yu.V.

1) MEDSI Group JSC, Moscow, Russia; 2) Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, Moscow, Russia; 3) Pirogov National Medical and Surgical Center, Ministry of Health of Russia, Moscow, Russia

This review presents the data of the recent studies on the structure and role of the vaginal microbiota in providing colonization resistance and maintaining female reproductive health. New therapeutic options in the treatment of infectious diseases in gynecology are covered. The review shows the significance of preserving the specific functioning of the vaginal microecosystem, searching for new effective therapeutic opportunities in the treatment of infectious and inflammatory diseases and correction of dysbiotic disorders of the vaginal microbiota, its ability to resist pathogenic microorganisms. The unique local immune status directly correlates with the specific microbial composition of the vagina. Recent studies have shown the high efficiency of intestinal microbiota transplantation in gastroenterology. To date, there is a promising concept of introducing selective microbiota transplantation into clinical practice. According to this concept, it is possible to obtain autoprobiotics that can simultaneously solve the problem of safety during transplantation and provide personalized treatment. It is necessary to carry out further studies on the characteristics of pharmacological properties, on degree of stability and safety, on the ability of microorganisms to multiply in the vagina, and on the determination of dosage and frequency of use. The effectiveness of vaginal microbiota transplantation should be determined and proven in subsequent randomized placebo-controlled clinical trials. Conclusion: Autoprobiotics originating from the vagina can become the basis for the development of personalized medicines using a person’s own microbiota as it is safe and accessible and can help in the treatment of diseases with complex etiology and pathogenesis. Preliminary clinical results in a number of experimental studies have demonstrated a good therapeutic effect and great prospects for vaginal microbiota transplantation in comparison with other methods of treatment.

Authors’ contributions: Kira E.F., Priputnevich T.V., Muravieva V.V. – planning, developing the design of the work, editing the text; Khalturina Yu.V. – search and analysis of literature data, writing the text.

Conflicts of interest: The authors declare no possible conflicts of interest.

Funding: The study was conducted without sponsorship.

For citation: Kira E.F., Priputnevich T.V., Muravieva V.V., Khalturina Yu.V. Vaginal microbiota transplantation. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2023; (10): 39-46 (in Russian) https://dx.doi.org/10.18565/aig.2023.142

Keywords

vaginal microbiota
microbiome
colonization resistance
bacterial vaginosis
vaginal microbiota transplantation
personalized probiotic
autoprobiotic
Full text (in Russian)

References

  1. Anton L., Sierra L.-J., DeVine A., Barila G., Heiser L., Brown A.G., Elovitz M.A. Common cervicovaginal microbial supernatants alter cervical epithelial func-tion: mechanisms by which Lactobacillus crispatus contributes to cervical health. Front. Microbiol. 2018; 9: 2181. https://dx.doi.org/10.3389/fmicb.2018.02181.
  2. Audirac-Chalifour A., Torres-Poveda K., Bahena-Román M., Téllez-Sosa J., Martínez-Barnetche J., Cortina-Ceballos B. et al. Microbiome and cytokine profile at various stages of cervical cancer: A pilot study. PLoS One. 2016; 11(4): e0153274. https://dx.doi.org/10.1371/journal.pone.0153274.
  3. Al-Nasiry S., Ambrosino E., Schlaepfer M., Morré S.A., Wieten L., Voncken J.W. et al. The interplay between reproductive tract microbiota and immunological system in human reproduction. Front. Immunol. 2020; 11: 378. https://dx.doi.org/10.3389/fimmu.2020.00378.
  4. Кира Е.Ф., Расторгуева Л.И., Халтурина Ю.В., Пушкина В.В. Инфекции влагалища. Двухэтапный метод лечения. Акушерство и гинекология. 2020; 4: 201-8. [Кira E.F., Rastorgueva L.I., Khalturina Yu.V., Pushkina V.V. Vaginal infections. Two-step treatment. Obstetrics and Gynecology. 2020; (4): 201-8. (in Russian)]. https://dx.doi.org/10.18565/aig.2020.4.201-208.
  5. Миханошина Н.В., Припутневич Т.В., Байрамова Г.Р. Роль Lactobacillus iners и ассоциированных с бактериальным вагинозом микроорганизмов в формировании микробиоты влагалища. Акушерство и гинекология. 2023; 1: 20-6. [Mikhanoshina N.V., Priputnevich T.V., Bairamova G.R. The role of Lactobacillus iners and bacterial vaginosis-associated microorganisms in making up the vaginal microbiota. Obstetrics and Gynecology. 2023; (1): 20-6. (in Russian)]. https://dx.doi.org/10.18565/aig.2022.246.
  6. Chen T., Xia C., Hu H., Wang H., Tan B., Tian P. et al. Dysbiosis of the rat vagina is efficiently rescued by vaginal microbiota transplantation or probiotic combination. Int. J. Antimicrob. Agents. 2021; 57(3): 106277. https://dx.doi.org/10.1016/j.ijantimicag.2021.106277.
  7. Coudray M.S., Madhivanan P. Bacterial vaginosis - a brief synopsis of the liter-ature. Eur. J. Obstet. Gynecol. Reprod. Biol. 2020; 245: 143-8. https://dx.doi.org/10.1016/j.ejogrb.2019.12.035.
  8. Martins B.C.T., Guimarгes R.A., Alves R.R.F., Saddi V.A. Bacterial vaginosis and cervical human papillomavirus infection in young and adult women: a systematic review and meta-analysis. Rev. Saude Publica. 2022; 56: 113. https://dx.doi.org/10.11606/s1518-8787.2022056004412.
  9. Lin W., Zhang Q., Chen Y., Chen L., Dong B., Sun P. The prevalence of human papillomavirus and bacterial vaginosis among young women in China: a cross sectional study. BMC Womens Health. 2021; 21(1): 409. https://dx.doi.org/10.1186/s12905-021-01504-0.
  10. Mehta S.D., Nandi D., Agingu W., Green S.J., Bhaumik D.K., Bailey R.C., Otieno F. Vaginal and penile microbiome associations with herpes simplex virus type 2 in women and their male sex partners. J. Infect. Dis. 2022; 226(4): 644-54. https://dx.doi.org/10.1093/infdis/jiaa529.
  11. Tachedjian G., O’Hanlon D.E., Ravel J. The implausible “in vivo” role of hydrogen peroxide as an antimicrobial factor produced by vaginal microbiota. Micro-biome. 2018; 6: 29.
  12. Wang J., Li Z., Ma X., Du L., Jia Z., Cui X. et al. Translocation of vaginal microbiota is involved in impairment and protection of uterine health. Nat. Commun. 2021; 12(1): 4191. https://dx.doi.org/10.1038/s41467-021-24516-8.
  13. Łaniewski P., Ilhan Z.E., Herbst-Kralovetz M.M. The microbiome and gynae-cological cancer development, prevention and therapy. Nat. Rev. Urol. 2020; 17(4): 232-50. https://dx.doi.org/10.1038/s41585-020-0286-z.
  14. Baker J.M., Chase D.M., Herbst-Kralovetz M.M. Uterine microbiota: residents, tourists, or invaders? Front. Immunol. 2018 ;9: 208. https://dx.doi.org/10.3389/fimmu.2018.00208.
  15. Chen C., Song X., Wei W., Zhong H., Dai J., Lan Z. et al. The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases. Nat. Commun. 2017; 8(1): 875. https://dx.doi.org/10.1038/s41467-017-00901-0.
  16. Lu F., Wei J., Zhong Y., Feng Y., Ma B., Xiong Y. et al. Antibiotic therapy and vaginal microbiota transplantation reduce endometriosis disease progression in fe-male mice via NF-κB signaling pathway. Front. Med. (Lausanne). 2022; 9: 831115. https://dx.doi.org/10.3389/fmed.2022.831115.
  17. Punzón-Jiménez P., Labarta E. The impact of the female genital tract microbiome in women health and reproduction: a review. J. Assist. Reprod. Genet. 2021;38(10):2519-41. https://dx.doi.org/10.1007/s10815-021-02247-5.
  18. Younes J.A., Lievens E., Hummelen R., van der Westen R., Reid G., Petrova M.I. Women and their microbes: the unexpected friendship. Trends Microbiol. 2018; 26(1): 16-32. https://dx.doi.org/10.1016/j.tim.2017.07.008.
  19. Koedooder R., Mackens S., Budding A., Fares D., Blockeel C., Laven J. et al. Identification and evaluation of the microbiome in the female and male reproductive tracts. Hum. Reprod. Update. 2019; 25(3): 298-325. https://dx.doi.org/10.1093/ humupd/dmy048.
  20. Benner M., Ferwerda G., Joosten I., Van der Molen R.G. How uterine microbiota might be responsible for a receptive, fertile endometrium. Hum. Reprod. Up-date. 2018; 24(4): 393-415. https://dx.doi.org/10.1093/humupd/dmy012.
  21. Walther-Antonio M.R.S., Chen J., Multinu F., Hokenstad A., Distad T.J., Cheek E.H. et al. Potential contribution of the uterine microbiome in the development of endometrial cancer. Genome Med. 2016; 8(1): 122. https://dx.doi.org/10.1186/s13073-016-0368-y.
  22. Ma D., Chen Y., Chen T. Vaginal microbiota transplantation for the treatment of bacterial vaginosis: a conceptual analysis. FEMS Microbiol. Lett. 2019; 366(4): fnz025. https://dx.doi.org/10.1093/femsle/fnz025.
  23. Wei K., Chen T. Vaginal microbiota transplantation for treatment of bacterial vaginosis: a review. Sheng Wu Gong Cheng Xue Bao. 2021; 37(11): 3820-7. https://dx.doi.org/10.13345/j.cjb.210163.
  24. Голощапов О.В., Чуракина Д.В., Кучер М.А., Клементьева Р.В., Сидоренко С.В., Гостев В.В., Карев В.Е., Суворова М.А., Шлык И.В., Чухловин А.Б., Зубаровская Л.С., Афанасьев Б.В. Трансплантация фекальной микрофлоры при критическом состоянии пациентов в онкогематологической практике. Вестник анестезиологии и реаниматологии. 2019; 16(3): 63-73. [Goloshchapov O.V., Churakina D.V., Kucher M.A., Klementeva R.V., Sidorenko S.V., Gostev V.V., Karev V.E., Suvorova M.A., Shlyk I.V., Chukhlovin A.B., Zubarovskaya L.S., Afanasyev B.V. Fecal microbiota transplantation in critical condition patients in hematological practice. Messenger of Anesthesiology and Resuscitation. 2019; 16(3): 63-73. (in Russian)]. https://dx.doi.org/10.21292/2078-5658-2019-16-3-63-73.
  25. Aroniadis O.C., Brandt L.J., Oneto C., Feuerstadt P., Sherman A., Wolkoff A.W. et al. Faecal microbiota transplantation for diarrhoea-predominant irritable bowel syndrome: a double-blind, randomised, placebo-controlled trial. Lancet Gastroenterol. Hepatol. 2019; 4(9): 675-85. https://dx.doi.org/10.1016/S2468-1253(19)30198-0.
  26. Bajaj J.S., Kassam Z., Fagan A., Gavis E.A., Liu E., Cox I.J. et al. Fecal microbiota transplant from a rational stool donor improves hepatic encephalopathy: a randomized clinical trial. Hepatology. 2017; 66(6): 1727-38. https://dx.doi.org/10.1002/hep.29306.
  27. Kang D.W., Adams J.B., Gregory A.C., Borody T., Chittick L., Fasano A. et al. Microbiota transfer therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study. Microbiome. 2017; 5(1): 10. https://dx.doi.org/10.1186/s40168-016-0225-7.
  28. El-Salhy M., Hatlebakk J.G., Gilja O.H., Brathen Kristoffersen A., Hausken T. Efficacy of faecal microbiota transplantation for patients with irritable bowel syndrome in a randomised, double-blind, placebo-controlled study. Gut. 2020; 69(5): 859-67. https://dx.doi.org/10.1136/gutjnl-2019-319630.
  29. Wu N., Li X., Ma H., Zhang X., Liu B., Wang Y. et al. The role of the gut microbiota and fecal microbiota transplantation in neuroimmune diseases. Front. Neurol. 2023; 14:1108738. https://dx.doi.org/10.3389/fneur.2023.1108738.
  30. DeLong K., Bensouda S., Zulfiqar F., Zierden H.C., Hoang T.M., Abraham Alison G. et al. Conceptual design of a universal donor screening approach for vaginal microbiota transplant. Front. Cell. Infect. Microbiol. 2019; 9: 306. https://dx.doi.org/10.3389/fcimb.2019.00306.
  31. Meng F.J. Therapy and mechanism of vaginal microbiota transplantation and combination of vaginal probiotics in the vaginal bacterial infections. Nanchang: Nanchang University; 2018. (in Chinese).
  32. Lev-Sagie A., Goldman-Wohl D., Cohen Y., Dori-Bachash M., Leshem A., Mor U. et al. Vaginal microbiome transplantation in women with intractable bacterial vaginosis. Nat. Med. 2019; 25(10):1500-4. https://dx.doi.org/10.1038/s41591-019-0600-6.
  33. Kim S., Seo H., Abdur Rahim M., Lee S., Kim Y.-S., Song H.-Y. Changes in the microbiome of vaginal fluid after menopause in Korean women. J. Microbiol. Biotechnol. 2021; 31(11): 1490-500. https://dx.doi.org/10.4014/jmb.2106.06022.
  34. Gardner H.L., Dukes C.D. Haemophilus vaginalis vaginitis: a newly defined specific infection previously classified "nonspecific" vaginitis. Am. J. Obstet. Gynecol. 1955; 69(5): 962-76. https://dx.doi.org/10.1016/0002-9378(55)9009-8.
  35. Zhang F., Cui B., He X., Nie Y., Wu K., Fan D.; FMT-standardization Study Group. Microbiota transplantation: concept, methodology and strategy for its modernization. Protein Cell. 2018, 9(5): 462-73. https://dx.doi.org/10.1007/s13238-018-0541-8.
  36. Javdan B., Lopez J.G., Chankhamjon P., Lee Y.-C.J., Hull R., Wu Q. et al. Personalized mapping of drug metabolism by the human gut microbiome. Cell. 2020; 181(7): 1661-79.e22. https://dx.doi.org/10.1016/j.cell.2020.05.001.
  37. Hoffmann D.E., Palumbo F.B., Ravel J., Rowthorn V., von Rosenvinge E. A proposed definition of microbiota transplantation for regulatory purposes. Gut Microbes. 2017; 8(3): 208-13. https://dx.doi.org/10.1080/19490976.2017.1293223.
  38. Humphries C. Microbiome: detecting diversity. Nature. 2017; 550(7674): S12-4. https://dx.doi.org/10.1038/550S12a.
  39. Parenteral and Enteral Nutrition Branch of Chinese Medical Association, Enhanced Recovery After Surgery Branch of China International Health Care Promotion and Exchange Association, China Microecological Treatment Innovation Alliance; Microecology Committee of Shanghai Preventive Medicine Association. Chinese experts consensus on clinical practice of the selection and establishment of fecal microbiota transplantation delivery routes. Zhonghua Wei Chang Wai Ke Za Zhi. 2020; 23(Z1): 14-20. (in Chinese). https://dx.doi.org/10.3760/cma.j.cn.441530-20200420-00228.
  40. Gerardin Y., Timberlake S., Allegretti J.R., Smith M.B, Kassam Z. Beyond fecal microbiota transplantation: developing drugs from the microbiome. J. Infect. Dis. 2021; 223(12, Suppl. 2): S276-82. https://dx.doi.org/10.1093/infdis/jiaa700.
  41. Berus S.M., Adamczyk-Popławska M., Goździk K., Przedpełska G., Szymborski T.R., Stepanenko Y., Kamińska A. SERS-PLSR analysis of vaginal microflora: towards the spectral library of microorganisms. Int. J. Mol. Sci. 2022; 23(20): 12576. https://dx.doi.org/10.3390/ijms232012576.
  42. Cammarota G., Ianiro G., Kelly C.R., Mullish B.H., Allegretti J.R., Kassam Z. et al. International consensus conference on stool banking for faecal microbiota transplantation in clinical practice. Gut. 2019; 68(12): 2111-21. https://dx.doi.org/10.1136/gutjnl-2019-319548.
  43. Kassam Z., Dubois N., Ramakrishna B., Ling K., Qazi T., Smith M. et al. Donor screening for fecal microbiota transplantation. N. Engl. J. Med. 2019; 381(21): 2070-2. https://dx.doi.org/10.1056/NEJMc1913670.
  44. Yockey L.J., Hussain F.A., Bergerat A., Reissis A., Worrall D., Xu J., Gomez I. Screening and characterization of vaginal fluid donations for vaginal microbiota transplantation. Sci. Rep. 2022; 12(1): 17948. https://dx.doi.org/10.1038/s41598-022-22873-y.
  45. Hoffmann D., Palumbo F., Ravel J., Roghmann M.C., Rowthorn V., von Rosenvinge E. Improving regulation of microbiota transplants. Science. 2017; 358(6369): 1390-1. https://dx.doi.org/10.1126/science.aaq0034.
  46. Ahannach S., Delanghe L., Spacova I., Wittouck S., Van Beeck W., De Boeck I., Lebeer S. Microbial enrichment and storage for metagenomics of vaginal, skin, and saliva samples. iScience. 2021; 24(11): 103306. https://dx.doi.org/10.1016/j.isci.2021.103306.
  47. Bokoliya S.C., Dorsett Y., Panier H., Zhou Y. Procedures for fecal microbiota transplantation in murine microbiome studies. Front. Cell. Infect. Microbiol. 2021; 11: 711055. https://dx.doi.org/10.3389/fcimb.2021.711055.
  48. Johnson S., Gerding D.N. Fecal fixation: fecal microbiota transplantation for Clostridium difficile infection. Clin. Infect. Dis. 2017; 64(3): 272-4. https://dx.doi.org/10.1093/cid/ciw735.
  49. Zasada A.A., Zacharczuk K., Woźnica K., Główka M., Ziółkowski R., Malinowska E. The influence of a swab type on the results of point-of-care tests. AMB Express. 2020; 10(1): 46. https://dx.doi.org/10.1186/s13568-020-00978-9.
  50. Fransson M.N., Rial-Sebbag E., Brochhausen M., Litton J.E. Toward a common language for biobanking. Eur. J. Hum. Genet. 2015; 23(1): 22-8. https://dx.doi.org/10.1038/ejhg.2014.45.

Received 07.06.2023

Accepted 15.09.2023

About the Authors

Evgeny F. Kira, Dr. Med. Sci., Professor, Honored Scientist of the Russian Federation, Honored Doctor of the Russian Federation, Academician of the Russian Academy of Natural Sciences, Head of the Department of Obstetrics and Gynecology, Medical Academy JSC «Group of Companies «MEDSI»», +7(985)188-87-86, profkira33@gmail.com, 123242, Russia, Moscow, Krasnaya Presnya str., 16.
Tatiana V. Priputnevich, Corresponding Member of the Russian Academy of Sciences, Dr. Med. Sci., Professor, Director of the Institute of Microbiology, Antimicrobial Therapy and Epidemiology, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation, +7(495)438-25-10, priput1@gmail.com, https://orcid.org/0000-0002-4126-9730, 117997, Russia, Moscow, Ac. Oparin str., 4.
Vera V. Muravieva, PhD (Bio), Senior Researcher, Laboratory of Molecular Microbiology, Department of Molecular Microbiology and Bioinformatics, Institute of Microbiology, Antimicrobial Therapy and Epidemiology, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation, +7(495)438-25-33, v_muravieva@oparina4.ru, https://orcid.org/0000-0003-0383-0731, 117997, Russia, Moscow, Ac. Oparin str., 4.
Yulija V. Khalturina, graduate student of the Institute for Advanced Medical Studies, N.I. Pirogov National Medical and Surgical Center, Ministry of Health of the Russian Federation, +7(499)464-53-87, julia.vladimirovna.103@gmail.com, https://orcid.org/0000-0001-6853-8518, 105203, Russia, Moscow, Nizhnyaya Pervomayskaya str., 65.

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