Vaginal microbiota transplantation

Kira E.F., Priputnevich T.V., Muravieva V.V., Khalturina Yu.V.

1) MEDSI Group JSC, Moscow, Russia; 2) Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, Moscow, Russia; 3) Pirogov National Medical and Surgical Center, Ministry of Health of Russia, Moscow, Russia

This review presents the data of the recent studies on the structure and role of the vaginal microbiota in providing colonization resistance and maintaining female reproductive health. New therapeutic options in the treatment of infectious diseases in gynecology are covered. The review shows the significance of preserving the specific functioning of the vaginal microecosystem, searching for new effective therapeutic opportunities in the treatment of infectious and inflammatory diseases and correction of dysbiotic disorders of the vaginal microbiota, its ability to resist pathogenic microorganisms. The unique local immune status directly correlates with the specific microbial composition of the vagina. Recent studies have shown the high efficiency of intestinal microbiota transplantation in gastroenterology. To date, there is a promising concept of introducing selective microbiota transplantation into clinical practice. According to this concept, it is possible to obtain autoprobiotics that can simultaneously solve the problem of safety during transplantation and provide personalized treatment. It is necessary to carry out further studies on the characteristics of pharmacological properties, on degree of stability and safety, on the ability of microorganisms to multiply in the vagina, and on the determination of dosage and frequency of use. The effectiveness of vaginal microbiota transplantation should be determined and proven in subsequent randomized placebo-controlled clinical trials. Conclusion: Autoprobiotics originating from the vagina can become the basis for the development of personalized medicines using a person’s own microbiota as it is safe and accessible and can help in the treatment of diseases with complex etiology and pathogenesis. Preliminary clinical results in a number of experimental studies have demonstrated a good therapeutic effect and great prospects for vaginal microbiota transplantation in comparison with other methods of treatment.

Authors’ contributions: Kira E.F., Priputnevich T.V., Muravieva V.V. – planning, developing the design of the work, editing the text; Khalturina Yu.V. – search and analysis of literature data, writing the text.

Conflicts of interest: The authors declare no possible conflicts of interest.

Funding: The study was conducted without sponsorship.

For citation: Kira E.F., Priputnevich T.V., Muravieva V.V., Khalturina Yu.V. Vaginal microbiota transplantation. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2023; (10): 39-46 (in Russian)


vaginal microbiota
colonization resistance
bacterial vaginosis
vaginal microbiota transplantation
personalized probiotic


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Received 07.06.2023

Accepted 15.09.2023

About the Authors

Evgeny F. Kira, Dr. Med. Sci., Professor, Honored Scientist of the Russian Federation, Honored Doctor of the Russian Federation, Academician of the Russian Academy of Natural Sciences, Head of the Department of Obstetrics and Gynecology, Medical Academy JSC «Group of Companies «MEDSI»», +7(985)188-87-86,, 123242, Russia, Moscow, Krasnaya Presnya str., 16.
Tatiana V. Priputnevich, Corresponding Member of the Russian Academy of Sciences, Dr. Med. Sci., Professor, Director of the Institute of Microbiology, Antimicrobial Therapy and Epidemiology, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation, +7(495)438-25-10,,, 117997, Russia, Moscow, Ac. Oparin str., 4.
Vera V. Muravieva, PhD (Bio), Senior Researcher, Laboratory of Molecular Microbiology, Department of Molecular Microbiology and Bioinformatics, Institute of Microbiology, Antimicrobial Therapy and Epidemiology, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation, +7(495)438-25-33,,, 117997, Russia, Moscow, Ac. Oparin str., 4.
Yulija V. Khalturina, graduate student of the Institute for Advanced Medical Studies, N.I. Pirogov National Medical and Surgical Center, Ministry of Health of the Russian Federation, +7(499)464-53-87,,, 105203, Russia, Moscow, Nizhnyaya Pervomayskaya str., 65.

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