Therapeutic opportunities of extracellular vesicles in reproductive medicine
Diminished ovarian reserve is an urgent problem of reproductive medicine. Currently, there are no scientifically based and proven methods for solving the problem. One of the promising directions in this area may be the use of extracellular vesicles (EVs) secreted by the cells of structures that have a high biological activity due to different molecules entering into their composition. From the point of view of therapeutic effects, EVs derived from the mesenchymal stromal cells (MSC) of different origins deserve attention. The use of MSC-EVs is currently being actively explored in different fields of regenerative medicine. According to the literature, the administration of MSC-EVs in animal models with ovarian insufficiency could increase the ovarian reserve, reproductive potential, and the effectiveness of assisted reproductive technologies programs. The use of MSC-EVs in medicine is limited by a small number of studies, the insufficient duration of an observation of the models treated with this method, and by the study of possible side effects.Kraevaya E.E., Makarova N.P., Sysoeva A.P., Kalinina E.A., Silachev D.N.
Conclusion. Taking into account the promising results of utilizing MSC-EVs in different fields of regenerative medicine and the data available in the literature on the possibility of increasing the ovarian reserve and improving the reproductive potential with MSC-EVs in the animal models, this method may be a promising treatment in patients with a low reproductive potential and ovarian insufficiency.
Keywords
extracellular vesicles
mesenchymal stromal cells
assisted reproductive technologies
ovarian reserve
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Received 27.04.2021
Accepted 18.05.2021
About the Authors
Elizaveta E. Kraevaya, Researcher at the Department of Assisted Technologies for the Treatment of Infertility, V.I. Kulakov NMRC for OG&P, Ministry of Health of Russia. E-mail: e_kraevaya@oparina4.ru. 117997, Russia, Moscow, Ac. Oparina str., 4.Natalya P. Makarova, Dr. Bio. Sci., Leading Researcher at the Department of Assisted Reproductive Technologies in the Treatment of Infertility, V.I. Kulakov
NMRC for OG&P, Ministry of Health of Russia. E-mail: np_makarova@oparina4.ru. 117997, Russia, Moscow, Ac. Oparina str., 4.
Anastasia P. Sysoeva, embryologist at the Department of Assisted Reproductive Technologies in the Treatment of Infertility, V.I. Kulakov NMRC for OG&P,
Ministry of Health of Russia. E-mail: a_sysoeva@oparina4.ru. 117997, Russia, Moscow, Ac. Oparina str., 4.
Elena A. Kalinina, Dr. Med. Sci., Professor, Head of the Department of Assisted Technologies for the Treatment of Infertility, Scientific Secretary of the Dissertation Council, V.I. Kulakov NMRC for OG&P, Ministry of Health of Russia. E-mail: e_kalinina@oparina4.ru. 117997, Russia, Moscow, Ac. Oparina str., 4.
Denis N. Silachev, Dr. Bio. Sci., Head of the Cell Technologies Laboratory, V.I. Kulakov NMRC for OG&P, Ministry of Health of Russia. E-mail: d_silachev@oparina4.ru.
117997, Russia, Moscow, Ac. Oparina str., 4.
For citation: Kraevaya E.E., Makarova N.P., Sysoeva A.P., Kalinina E.A., Silachev D.N. Therapeutic opportunities of extracellular vesicles in reproductive medicine.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2021; 7: 5-9 (in Russian)
https://dx.doi.org/10.18565/aig.2021.7.5-9
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