Super-selective chemoembolization in locally advanced cervical cancer
Aim. To investigate the effectiveness of super-selective chemoembolization (SCE) in locally advanced cervical cancer.Maksimov S.Ya., Khadzhimba A.S., Il’in A.A., Pletneva A.V., Smirnova M.P., Balakhnin P.V.
Materials and methods. The study comprised 17 patients with stage IB2-IIIB cervical cancer who underwent SCE, which was performed using HepaSphere drug-loaded microspheres. Oxaliplatin (100 mg) was used as a cytostatic agent. The treatment response was evaluated by magnetic resonance imaging (MRI) 3 weeks after SCE.
Results. The best treatment response was observed in patients with stage IB2 disease. Stabilization was achieved in 4/17 (67%) patients. A partial response was observed in 2/17 (33%). In patients with stage IIA disease, a partial response was observed in 2/17 (67%) patients. In 1 patient, stabilization of the process was established. Among patients with stage IIIB disease, the best treatment response was achieved in 1 patient, who had a 13% reduction in tumor size. In the remaining 2 cases, the effect of treatment was negligible (5 and 6% tumor size reduction). About half (47%) of patients developed a postembolization syndrome.
Conclusion. To date, sufficient experience has not yet been gained to draw definite conclusions about the effectiveness of SCE. However, the fact that this treatment modality has all the advantages of intra-arterial chemotherapy while avoiding its adverse effects, its use may offer promising results.
Keywords
cervical cancer
super-selective chemoembolization
uterine artery embolization
chemotherapy
microspheres
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Received 06.12.2019
Accepted 25.12.2019
About the Authors
Sergey Y. Maksimov, MD, oncologist, professor. Head of gynaecological department, Saint-Petersburg clinical scientific and practical center for special types of medical care (oncology-oriented). E-mail: s.maximov@mail.ru. Тел.: +79219393753. http://orcid.org/0000-0003-3746-0855197758 Russia, Saint Petersburg, set. Pesochniy, str. Leningradskaya, 68А let.A.
Angella S. Khadgimba, MD, oncologist. Gynaecological department, Saint-Petersburg clinical scientific and practical center for special types of medical care
(oncology-oriented). E-mail: khadzhimba@gmail.com. Тел.:+79219515855 http://orcid.org/0000-0002-8247-0238
197758 Russia, Saint Petersburg, set. Pesochniy, str. Leningradskaya, 68А let.A.
Anton A. Ilin, oncologist. Gynaecological department, Saint-Petersburg clinical scientific and practical center for special types of medical care (oncology-oriented).
E-mail: ilin.doc@gmail.com. Тел.:+79214104343. http://orcid.org/0000-0002-8309-8570
197758 Russia, Saint Petersburg, set. Pesochniy, str. Leningradskaya, 68А let.A.
Alesya V. Pletneva, resident. St. Petersburg State Pediatric Medical University of the Ministry of Healthcare of the Russian Federation. E-mail: alesyapletneva@list.ru. Тел.:+79214239738. http://orcid.org/0000-0001-5621-7549
194100 Russia, Saint Petersburg, str. Litovskaya 2.
Marta P. Smirnova, oncologist. Gynaecological department, Saint-Petersburg clinical scientific and practical center for special types of medical care (oncology-oriented).
E-mail: smirnova.mrp@gmail.com. Тел.:+79219562878. http://orcid.org/0000-0001-7387-7573
197758 Russia, Saint Petersburg, set. Pesochniy, str. Leningradskaya, 68А let.A.
Pavel D. Balahnin, PhD, oncologist. Head of x-ray surgery department, Saint-Petersburg clinical scientific and practical center for special types of medical care
(oncology-oriented). E-mail: balahnin_p@mail.ru. Тел.:+79119337953.
Russia 197758, Saint Petersburg, set. Pesochniy, str. Leningradskaya, 68А let.A.
For citation: Maksimov S.Ya., Khadzhimba A.S., Il’in A.A., Pletneva A.V., Smirnova M.P., Balakhnin P.V. Super-selective chemoembolization in locally advanced cervical cancer.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2020; 1(Suppl): 98-104 (in Russian)
https://dx.doi.org/10.18565/aig.2020.1suppl. 98-104
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