A rare localization of ectopic pregnancy: cervical and cesarean scar pregnancy

Danilov A.A., Kozachenko A.V.

Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, Moscow, Russia

This review presents the main aspects of a rare localization of ectopic pregnancy, namely cervical and cesarean scar pregnancy. It should be noted that the incidence of this type of ectopic pregnancy is increasing in the modern world.  In addition to the well-known risk factors for ectopic pregnancy, the increasing prevalence of abdominal-pelvic surgery, assisted reproductive technologies (ART), and operative abdominal delivery are discussed as potential contributing factors. This paper considers the pathogenetic mechanisms of ectopic pregnancy that may occur in the cesarean scar and in the cervix, as well as the classification of pregnancy variants and the diagnostic methods that may be used to identify these variants. The article presents an overview of the various tactical approaches to surgical and non-surgical treatment, combinations of different techniques aimed at preserving the organ and reproductive potential.  
Conclusion: Due to the unique nature of this pathology, there is no single algorithm for diagnosis and treatment, and various therapeutic approaches are used. Therefore, further studies are required to improve the management of ectopic pregnancies with rare localization.

Authors’ contributions: Kozachenko A.V. – writing and final editing of the text of the article; Danilov A.A. – selecting sources of literature, writing the text of the article.
Conflicts of interest: Authors declare lack of the possible conflicts of interest.
Funding: The study was carried out without sponsorship.
For citation: Danilov A.A., Kozachenko A.V. 
A rare localization of ectopic pregnancy: cervical and cesarean scar pregnancy.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2024; (11): 5-11 (in Russian)
https://dx.doi.org/10.18565/aig.2024.248

Keywords

ectopic pregnancy
cervical pregnancy
cesarean scar pregnancy
hysteroresectoscopy
methotrexate
uterine artery embolization

References

  1. Po L., Thomas J., Mills K., Zakhari A., Tulandi T., Shuman M. et al. Guideline No. 414: management of pregnancy of unknown location and tubal and nontubal ectopic pregnancies. J. Obstet. Gynaecol. Can. 2021; 43(5): 614-630.e1. https://dx.doi.org/10.1016/j.jogc.2021.01.002.
  2. Baggio S., Garzon S., Russo A., Ianniciello C.Q., Santi L., Laganà A.S. et al. Fertility and reproductive outcome after tubal ectopic pregnancy: comparison among methotrexate, surgery and expectant management. Arch. Gynecol. Obstet. 2021; 303(1): 259-68. https://dx.doi.org/10.1007/s00404-020-05749-2.
  3. Mullany K., Minneci M., Monjazeb R., C Coiado O. Overview of ectopic pregnancy diagnosis, management, and innovation. Womens Health (Lond.). 2023; 19: 17455057231160349. https://dx.doi.org/10.1177/17455057231160349.
  4. Chong K.Y., Solangon S., Barnhart K., Causa-Andrieu P., Capmas P., Condous G. et al.; International Collaboration on Core Outcomes in Ectopic Pregnancy. A core outcome set for future research in ectopic pregnancy: an international consensus development study. Fertil. Steril. 2023; 119(5): 804-12. https://dx.doi.org/10.1016/j.fertnstert.2023.01.042.
  5. Chouinard M., Mayrand M.H., Ayoub A., Healy-Profitós J., Auger N. Ectopic pregnancy and outcomes of future intrauterine pregnancy. Fertil. Steril. 2019; 112(1): 112-9. https://dx.doi.org/10.1016/j.fertnstert.2019.03.019.
  6. Roitman M.S., Wainstock T., Sheiner E., Leibson T., Pariente G. Ectopic pregnancy: perinatal outcomes of future gestations and long-term neurological morbidity of the offspring. Arch. Gynecol. Obstet. 2021; 304(3): 633-40. https://dx.doi.org/10.1007/s00404-021-05991-2.
  7. Jin X., Liu M., Zhang P., Zheng L., Qi F. Subsequent fertility after cesarean scar pregnancy: a retrospective analysis. BMC Pregnancy Childbirth. 2023; 23(1): 337. https://dx.doi.org/10.1186/s12884-023-05584-8.
  8. American College of Obstetricians and Gynecologists' Committee on Practice Bulletins - Gynecology. ACOG Practice Bulletin No. 193: tubal ectopic pregnancy. Obstet. Gynecol. 2018; 131(3): e91-e103. https://dx.doi.org/10.1097/AOG.0000000000002560.
  9. Hendriks E., Rosenberg R., Prine L. Ectopic pregnancy: diagnosis and management. Am. Fam. Physician. 2020; 101(10): 599-606.
  10. Maleki A., Khalid N., Rajesh Patel C., El-Mahdi E. The rising incidence of heterotopic pregnancy: current perspectives and associations with in-vitro fertilization. Eur. J. Obstet. Gynecol. Reprod. Biol. 2021; 266: 138-44. https://dx.doi.org/10.1016/j.ejogrb.2021.09.031.
  11. Ucisik-Keser F.E., Matta E.J., Fabrega M.G., Chandrasekhar C., Chua S.S. The many faces of ectopic pregnancies: demystifying the common and less common entities. Abdom. Radiol (NY). 2021; 46(3): 1104-14. https://dx.doi.org/10.1007/s00261-020-02681-6.
  12. Brady P.C. New evidence to guide ectopic pregnancy diagnosis and management. Obstet. Gynecol. Surv. 2017; 72(10): 618-25. https://dx.doi.org/10.1097/OGX.0000000000000492.
  13. Naik S., Kumar S., Rani A., Patil S., Voorkara U., Kamath V.S. Interventional challenges in non-tubal ectopic pregnancy. J. Family Reprod. Health. 2022; 16(1): 78-85. https://dx.doi.org/10.18502/jfrh.v16i1.8597.
  14. Cheng L.Y., Lin P.Y., Huang F.J., Kung F.T., Chiang H.J., Lin Y.J. et al. Ectopic pregnancy following in vitro fertilization with embryo transfer: a single-center experience during 15 years. Taiwan. J. Obstet. Gynecol. 2015; 54(5): 541-5. https://dx.doi.org/10.1016/j.tjog.2015.08.004.
  15. Houser M., Kandalaft N., Khati N.J. Ectopic pregnancy: a resident's guide to imaging findings and diagnostic pitfalls. Emerg. Radiol. 2022; 29(1): 161-72. https://dx.doi.org/10.1007/s10140-021-01974-7.
  16. Silva B., Viana Pinto P., Costa M.A. Cesarean scar pregnancy: a systematic review on expectant management. Eur. J. Obstet. Gynecol. Reprod. Biol. 2023; 288: 36-43. https://dx.doi.org/10.1016/j.ejogrb.2023.06.030.
  17. Kostroun K., Go V.A., Robinson R.D. An update and review of nontubal ectopic pregnancy management. Curr. Opin. Obstet. Gynecol. 2023; 35(4): 279-87. https://dx.doi.org/10.1097/GCO.0000000000000893.
  18. Stabile G., Mangino F.P., Romano F., Zinicola G., Ricci G. Ectopic cervical pregnancy: treatment route. Medicina (Kaunas). 2020; 56(6): 293. https://dx.doi.org/10.3390/medicina56060293.
  19. Maglic R., Rakic A., Nikolic B., Maglic D., Jokanovic P., Mihajlovic S. Management of cervical ectopic pregnancy with small-caliber hysteroscopy. JSLS. 2021; 25(2): e2021.00016. https://dx.doi.org/10.4293/JSLS.2021.00016.
  20. Guo E.J., Chung J.P.W., Poon L.C.Y., Li T.C. Reproductive outcomes after surgical treatment of Asherman syndrome: a systematic review. Best Pract. Res. Clin. Obstet. Gynaecol. 2019; 59: 98-114. https://dx.doi.org/10.1016/j.bpobgyn.2018.12.009.
  21. Roche C., McDonnell R., Tucker P., Jones K., Milward K., McElhinney B. et al. Caesarean scar ectopic pregnancy: evolution from medical to surgical management. Aust. N. Z. J. Obstet. Gynaecol. 2020; 60(6): 852-7. https://dx.doi.org/10.1111/ajo.13241.
  22. Jordans I.P.M., Verberkt C., De Leeuw R.A., Bilardo C.M., Van Den Bosch T., Bourne T. et al. Definition and sonographic reporting system for Cesarean scar pregnancy in early gestation: modified Delphi method. Ultrasound Obstet. Gynecol. 2022; 59(4): 437-49. https://dx.doi.org/10.1002/uog.24815.
  23. Doroszewska K., Milewicz T., Bereza T., Horbaczewska A., Komenda J., Kłosowicz E. et al. Cesarean scar pregnancy - various methods of treatment. Folia Med. Cracov. 2019; 59(2): 5-14.
  24. Tang Q., Qin Y., Zhou Q., Tang J., Zhou Q., Qiao J. et al. Hysteroscopic treatment and reproductive outcomes in cesarean scar pregnancy: experience at a single institution. Fertil. Steril. 2021; 116(6): 1559-66. https://dx.doi.org/10.1016/j.fertnstert.2021.06.015.
  25. Timor-Tritsch I.E., Monteagudo A., Calì G., D'Antonio F., Kaelin Agten A. Cesarean scar pregnancy: diagnosis and pathogenesis. Obstet. Gynecol. Clin. North Am. 2019; 46(4): 797-811. https://dx.doi.org/10.1016/j.ogc.2019.07.009.
  26. Сонова М.М., Гашенко В.О., Ласкевич А.В., Торубаров С.Ф. Эктопическая беременность в рубце после кесарева сечения. Проблемы репродукции. 2018; 24(1): 42-7. [Sonova M.M., Gashenko V.O., Laskevich A.V., Torubarov S.F. The case of ectopic pregnancy in cesarean section scar. Russian Journal of Human Reproduction. 2018; 24(1): 42-7. (in Russian)]. https://dx.doi.org/10.17116/repro201824142-47.
  27. Yang X., Zheng W., Zhang H., Wei X., Yan J., Yang H. Expectant management of cesarean scar pregnancy in 13 patients. J. Matern. Fetal Neonatal. Med. 2022; 35(25): 8066-71. https://dx.doi.org/10.1080/14767058.2021.1940942.
  28. Sokalska A., Rambhatla A., Dudley C., Bhagavath B. Nontubal ectopic pregnancies: overview of diagnosis and treatment. Fertil. Steril. 2023;120(3 Pt. 2): 553-62. https://dx.doi.org/10.1016/j.fertnstert.2023.07.014.
  29. Calí G., Timor-Tritsch I.E., Forlani F., Palacios-Jaraquemada J., Monteagudo A., Kaelin Agten A. et al. Value of first-trimester ultrasound in prediction of third-trimester sonographic stage of placenta accreta spectrum disorder and surgical outcome. Ultrasound Obstet. Gynecol. 2020; 55(4): 450-9. https://dx.doi.org/10.1002/uog.21939.
  30. Hoffman T., Lin J. Cesarean scar ectopic pregnancy: diagnosis with ultrasound. Clin. Pract. Cases Emerg. Med. 2020; 4(1): 65-8. https://dx.doi.org/10.5811/cpcem.2019.10.43988.
  31. Rasheedy R., Sammour H., Elkholy A., Fadel E. Agreement between transvaginal ultrasound and saline contrast sonohysterography in evaluation of cesarean scar defect. J. Gynecol. Obstet. Hum. Reprod. 2019; 48(10): 827-31. https://dx.doi.org/10.1016/j.jogoh.2019.05.013.
  32. Noël L., Thilaganathan B. Caesarean scar pregnancy: diagnosis, natural history and treatment. Curr. Opin. Obstet. Gynecol. 2022; 34(5): 279-86. https://dx.doi.org/10.1097/GCO.0000000000000808.
  33. Xiao C., Shi Q., Cheng Q., Xu J. Non-surgical management of tubal ectopic pregnancy: a systematic review and meta-analysis. Medicine (Baltimore). 2021; 100(50): e27851. https://dx.doi.org/10.1097/MD.0000000000027851.
  34. Huo S., Shen L., Ju Y., Liu K., Liu W. Treatments for cesarean scar pregnancy: 11-year experience at a medical center. J. Matern. Fetal Neonatal Med. 2023; 36(1): 2162818. https://dx.doi.org/10.1080/14767058.2022.2162818.
  35. Stabile G., Zinicola G., Romano F., Buonomo F., Mangino F.P., Ricci G. Management of non-tubal ectopic pregnancies: a single center experience. Diagnostics (Basel). 2020; 10(9): 652. https://dx.doi.org/10.3390/diagnostics10090652.
  36. Yamaguchi M., Ohba T., Katabuchi H. Safety and efficacy of a single local methotrexate injection for cesarean scar pregnancy. J. Minim. Invasive Gynecol. 2022; 29(3): 416-23. https://dx.doi.org/10.1016/j.jmig.2021.11.008.
  37. Tanos V., ElAkhras S., Kaya B. Hysteroscopic management of cervical pregnancy: case series and review of the literature. J. Gynecol. Obstet. Hum. Reprod. 2019; 48(4): 247-53. https://dx.doi.org/10.1016/j.jogoh.2018.05.001.
  38. Masten M., Alston M. Treatment of recurrent cesarean scar pregnancy with oral mifepristone, systemic methotrexate, and ultrasound-guided suction dilation and curettage. Cureus. 2023; 15(3): e36200. https://dx.doi.org/10.7759/cureus.36200.
  39. Diakosavvas M., Kathopoulis N., Angelou K., Chatzipapas I., Zacharakis D., Kypriotis K. et al. Hysteroscopic treatment of cesarean scar pregnancy: a systematic review. Eur. J. Obstet. Gynecol. Reprod. Biol. 2022; 270: 42-9. https://dx.doi.org/10.1016/j.ejogrb.2021.12.038.
  40. Casadio P., Ambrosio M., Verrelli L., Salucci P., Arena A., Seracchioli R. Conservative cesarean scar pregnancy treatment: local methotrexate injection followed by hysteroscopic removal with hysteroscopic tissue removal system. Fertil. Steril. 2021; 116(5): 1417-9. https://dx.doi.org/10.1016/j.fertnstert.2021.06.034.
  41. Zhu W., Zhang X., Liu C., Liu Y., Xu W. Uterine artery embolization on serum β-HCG levels, fertility function and clinical efficacy in patients with cesarean uterine scar pregnancy. Front. Surg. 2022; 9: 838879. https://dx.doi.org/10.3389/fsurg.2022.838879.
  42. Давыдов А.И., Рубина Е.В., Пашков В.М., Шахламова М.Н. Редкие формы внематочной беременности: методология и отдаленные результаты лечения. Вопросы гинекологии, акушерства и перинатологии. 2019; 18(2): 69-75. [Davydov A.I., Rubina E.V., Pashkov V.M., Shakhlamova M.N. Rare types of ectopic pregnancy: methodology and long-term outcomes of treatment. Obstetrics, Gynecology and Perinatology. 2019; 18(2): 69-75. (in Russian)]. https://dx.doi.org/10.20953/1726-1678-2019-2-69-75.
  43. Imai K., Fukushi Y., Nishimura M., Ohara Y., Suzuki Y., Ota H. et al. Combination of conservative treatment and temporary bilateral laparoscopic uterine artery clipping with hysteroscopic transcervical resection for cervical pregnancy: a retrospective study. J. Gynecol. Obstet. Hum. Reprod. 2021; 50(4): 101735. https://dx.doi.org/10.1016/j.jogoh.2020.101735.
  44. Cao L., Qian Z., Huang L. Comparison of D&C and hysteroscopy after UAE in the treatment of cesarean scar pregnancy: a case-control study. Medicine (Baltimore). 2022; 101(3): e28607. https://dx.doi.org/10.1097/MD.0000000000028607.
  45. Fowler M.L., Wang D., Chia V., Handal-Orefice R., Latortue-Albino P., Mulekar S. et al. Management of cervical ectopic pregnancies: a scoping review. Obstet. Gynecol. 2021; 138(1): 33-41. https://dx.doi.org/10.1097/AOG.0000000000004423.
  46. Marchand G.J., Masoud A.T., Coriell C., Ulibarri H., Parise J., Arroyo A. et al. Treatment of cesarean scar ectopic pregnancy in China with uterine artery embolization - a systematic review and meta-analysis. J. Clin. Med. 2022; 11(24): 7393. https://dx.doi.org/10.3390/jcm11247393.
  47. Long Y., Zhu H., Hu Y., Shen L., Fu J., Huang W. Interventions for non-tubal ectopic pregnancy. Cochrane Database Syst. Rev. 2020; 7(7): CD011174. https://dx.doi.org/10.1002/14651858.CD011174.pub2.

Received 09.10.2024

Accepted 29.10.2024

About the Authors

Anton A. Danilov, PhD student at Gynecological Department, Academician V.I. Kulakov NMRC for OG&P, Ministry of Health of Russia, 117997, Russia, Moscow,
Ac. Oparin str., 4, +7(495)438-77-83, an_danilov@oparina4.ru, https://orcid.org/0009-0005-2461-5354
Andrey V. Kozachenko, Dr. Med. Sci., Leading Researcher, Academician V.I. Kulakov NMRC for OG&P, Ministry of Health of Russia, 117997, Russia, Moscow,
Ac. Oparin str., 4, +7(916)614-41-32, a_kozachenko@oparina4.ru, https://orcid.org/0000-0002-5573-6694

Similar Articles

By continuing to use our site, you consent to the processing of cookies that ensure the proper functioning of the site.