The health status of a baby born to a heart transplant woman: A сlinical case
Background. The number of pregnancies following solid organ transplantation is increasing all over the world. There are now few articles in the literature on the health status of babies born to mothers with transplanted organs.Shatalova E.A., Zubkov V.V., Kravchenko N.F., Vanko L.V., Ionov O.V., Ryumina I.I., Degtyareva A.V.
A case report. The paper presents a clinical observation of the health status of an infant born to a heart transplant patient at his birth and at the age of 5 years, whose prenatal development proceeded during maternal use of azathioprine and tacrolimus. Complex clinical and laboratory examination did not reveal gross malformations in the baby. His severe status at birth and during neonatal period is due to prematurity, congenital pneumonia, and birth asphyxia.
Conclusion. The pregnancy outcomes may be favorable in women after heart transplantation. The given clinical case shows the absence of gross malformation in the child and the correspondence of his psycho-motor and physical development with age. However, there is a need for investigations using a larger sample of infants born to mothers with transplanted organs in order to elaborate tactics of their management in the neonatal period and at an older age.
Keywords
newborn infant
pregnancy after heart transplantation
immunosuppressive therapy
azathioprine
tacrolimus
Supplementary Materials
References
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Received 24.04.2017
Accepted 28.04.2017
About the Authors
Shatalova Ekaterina Aleksandrovna, post-graduate student of the Department of Anesthesiology, Intensive Care and Neonatal Intensive Care, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. E-mail: e_shatalova@oparina4.ruZubkov Viktor Vasilievich, MD, head of the department. Department of neonatology and pediatrics, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia; Professor of the Department of Neonatology, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. E-mail: v_zubkov@oparina4.ru
Kravchenko Natalia Fedorovna, Ph.D., Senior Researcher of the 1st Obstetric Department of the Pathology of Pregnancy, Research Center of Obstetrics,
Gynecology and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. E-mail: n_kravchenko@oparina4.ru
Vanko Lyudmila Viktorovna, MD, Professor, Leading Researcher, Laboratory of Clinical Immunology, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. E-mail: l_Vanko@oparina4.ru
Ionov Oleg Vadimovich, Candidate of Medical Science, Head. Department of resuscitation and intensive care of newborns, Research Center of Obstetrics,
Gynecology and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. E-mail: o_ionov@oparina4.ru
Ryumina Irina Ivanovna, MD, head of the department. Department of Pathology of Newborns and Premature Children, Research Center of Obstetrics,
Gynecology and Perinatology, Ministry of Health of Russia; Professor of the Department of Neonatology of I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. E-mail: i_ryumina@oparina4.ru
Anna Vladimirovna Degtyareva, MD, a pediatrician of the highest category, the head of the scientific advisory pediatric department of the, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia; Professor of the Department of Neonatology of I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. E-mail: a_degtyareva@oparina4.ru
For citations: Shatalova E.A., Zubkov V.V., Kravchenko N.F., Vanko L.V., Ionov O.V., Ryumina I.I., Degtyareva A.V. The health status of a baby born to a heart transplant woman: A сlinical case. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (8): 126-31. (in Russian)
http://dx.doi.org/10.18565/aig.2017.8.126-31
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