Pregnancy after solid organ transplantation: Complications, outcomes, prospects
Objective. To carry out a systematic analysis of the data available in the current literature, which reflect the state of the problem of pregnancy after solid organ transplantation worldwide.Shatalova E.A., Zubkov V.V., Shmakov R.G., Podurovskaya Yu.L., Kravchenko N.F., Vanko L.V.
Materials and methods. The review includes the data of foreign and Russian articles published in the past 14 years and found in Pubmed on this topic.
Results. The paper describes the impact of immunosuppressive therapy on fertility, a developing fetus, and graft function. It presents the latest results of investigations dealing with breastfeeding in the use of immunosuppressive agents, as well as the obtained data on the health status of infants born to mothers with transplanted organs.
Conclusion. Posttransplantation pregnancy is associated with a high risk of complications for both mother and fetus. The integrated approach applied by obstetricians/gynecologists, immunologists, and transplantologists to this patient group reduces maternal and reproductive losses. It is necessary to conduct further studies aimed at investigating of the long-term consequences of the intrauterine effect of immunosuppressive therapy on the developing fetus.
Keywords
pregnancy after transplantation
immunosuppressive medications and fetus
cyclosporine
tacrolimus
Supplementary Materials
References
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Received 06.10.2016
Accepted 11.11.2016
About the Authors
Shatalova Ekaterina Aleksandrovna, post-graduate student of the Department of Anesthesiology and Intensive Care of Newborns, Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. E-mail: e_shatalova@oparina4.ruZubkov Victor Vasilievich, doctor of medical sciences, head of the department of neonatology and pediatrics, Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. E-mail: v_zubkov@oparina4.ru
Shmakov Roman Georgievich, Doctor of Medicine, Chief Physician of the Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. E-mail: r_shmakov@oparina4.ru
Podurovskaya Julia Leonidovna, Candidate of Medical Sciences, Head of the Department of Neonatal Surgery, Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. E-mail: y_podurovskaya@oparina4.ru
Kravchenko Natalia Fedorovna, Candidate of Medical Sciences, Senior Researcher of the 1st Obstetric Department of the Pathology of Pregnancy, Research Center
for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. E-mail: n_kravchenko@oparina4.ru
Vanko Lyudmila Viktorovna, Doctor of Medicine, Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. E-mail: l_Vanko@oparina4.ru
For citations: Shatalova E.A., Zubkov V.V., Shmakov R.G., Podurovskaya Yu.L.,
Kravchenko N.F., Vanko L.V. Pregnancy after solid organ transplantation:
Complications, outcomes, prospects.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (7): 5-11. (in Russian)
http://dx.doi.org/10.18565/aig.2017.7.5-11
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