Pregnancy problems in kidney transplant recipients

Pilia Z.A., Khodhaeva Z.S., Kravchenko N.F., Kirsanova T.V.

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia
Pregnancy in patients after kidney transplantation continues to be an urgent problem due to the high risk of complications. The review includes scientific publications over the past 10 years (mainly systematic reviews and meta-analyses by foreign and Russian authors), which have been found in the Pubmed database and on other available search platforms: Cochrane, Web of Science, MEDLINE, and Google Scholar. It summarizes the existing data on the course of pregnancy, the nature of immunosuppressive therapy in accordance with kidney transplant function and gestational complications, the possibility of their early prediction for prevention and timely therapy.
Conclusion. Further studies on the identification of the predictors of early-stage kidney damage are needed to reduce the incidence of pregnancy complications and to improve prospects for long-term graft survival.


kidney transplantation
markers for acute renal damage
kidney transplant dysfunction
immunosuppressive therapy


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Received 21.01.2020

Accepted 07.02.2020

About the Authors

Zafida A. Piliya, Postdoc of High Risk Pregnancy Department, National Medical Research Center for Obstetrics, Gynecology and Perinatology named
after Academician V.I. Kulakov Ministry of Healthcare of Russia. Tel.: +7(495)438-06-74. E-mail:
4 Academica Oparina st., 117997, Moscow, Russia.
Zulfiya S. Khodzhaeva MD, Professor, Deputy Director of Obstetrics Institute, National Medical Research Center for Obstetrics, Gynecology and Perinatology named
after Academician V.I. Kulakov Ministry of Healthcare of Russia. Tel.: +7 (495)438-07-88. E-mail:
4 Academica Oparina st., 117997, Moscow, Russia.
Natalia F. Kravchenko, Senior researcher of High Risk Pregnancy Department, National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Healthcare of Russia. Tel.: +7 (495)438-07-88. E-mail:
4 Academica Oparina st., 117997, Moscow, Russia.
Tatiana V. Kirsanova, Senior researcher of Reprodactive Hematology and Clinical Hemostasiology Department, National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Healthcare of Russia. Tel.: +7(495)438-07-88. E-mail:
4 Academica Oparina st., 117997, Moscow, Russia.

For reference: Pilia Z.A., Khodhaeva Z.S., Kravchenko N.F., Kirsanova T.V. Pregnancy problems in kidney transplant recipients.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2020; 6: 14-20 (in Russian)

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