Blood cytokine levels in neonates born to mothers with cancer who received antitumor chemotherapy during pregnancy
Objective. To determine the levels of cytokines, chemokines, and growth factors in the peripheral blood of women with cancer who took antitumor chemotherapy during pregnancy and in the blood of their neonates.Zhukova A.S., Makieva M.I., Vanko L.V., Vtorushina V.V., Matveeva N.K., Tsoi T.A., Volochaeva M.V., Timofeeva L.A., Krechetova L.V., Zubkov V.V., Shmakov R.G.
Subjects and methods. Multiplex analysis was used to estimate the levels of 17 factors in the plasma of women taking antitumor chemotherapy during pregnancy as in the umbilical cord and venous blood of their babies. A comparison group consisted of women with physiological pregnancy and their neonates.
Results. The cytokine-producing ability of immune cells relative to the corresponding indicators in the comparison group was reduced in women with cancer who took antitumor chemotherapy during pregnancy. The medications used by the mother did not have a substantial effect on the umbilical cord blood level of cytokines in newborn infants. By the end of the neonatal period, the babies had lower blood concentrations of IL-6, IL-8, IL-9, IL-12, MCP-1, MIP-1β, VEGF, and GM-CSF than those aged 3 days of life.
Conclusion. The use of antitumor chemotherapy during pregnancy lowers the secretory activity of the immune cells of women and has no significant effect on the level of cytokines, chemokines, and growth factors in the umbilical cord blood plasma of neonates.
Keywords
cytokines
newborn infant
oncology
References
1. Triunfo S., Scambia G. Cancer in pregnancy: diagnosis, treatment and neonatal outcome. Minerva Ginecol. 2014; 66(3): 325-34.
2. Salani R., Billingsley C., Crafton S. Cancer and pregnancy: an overview for obstetricians and gynecologist. Am. J. Obstet. Gynecol. 2014; 211(1): 7-14.
3. Disis M.L. Immune regulation of cancer. J. Сlin. Oncol. 2010; 28(29): 4531-8.
4. Saito Sh., Nakashima A., Shima T., Ito M. Th1/Th2/Th17 and regulatory T-cell paradigm in pregnancy. Am. J. Reprod. Immunol. 2010;63(6): 601-10.
5. Esposito S., Tenconi R., Preti V., Groppali E., Principi N. Chemotherapy against cancer during pregnancy. Medicine (Baltimore). 2016; 95(38): e4899.
6. Abdalla N., Bizoń M., Piórkowski R., Stanirowski P., Cendrowski K., Sawicki W. Does chemotherapy for gynecological malignancies during pregnancy cause fetal growth restriction? Biomed. Res. Int. 2017; 2017: 7543421.
7. Vandenbroucke T., Verheecke M., Fumagalli M., Lok C., Amant F. Effects of cancer treatment during pregnancy on fetal and child development. Lancet Child Adolesc. Health. 2017; 1(4): 302-10.
8. Seruga B., Zhang H., Bernstein L.J., Tannock I.F. Cytokines and their relationship to the symptoms and outcome of cancer. Nat. Rev. Cancer. 2008; 8(11): 887-99.
9. Cheung Y.T., Ng T., Shwe M., Ho H.K., Foo K.M., Cham M.T. et al. Association of proinflammatory cytokines and chemotherapy-associated cognitive impairment in breast cancer patients: a multi-centered, prospective, cohort study. Ann. Oncol. 2015; 26(7): 1446-51.
10. Walton J.R., Prasad M.R. Obstetric and neonatal outcomes of cancer treated during pregnancy. Clin. Obstet. Gynecol. 2011; 54(4): 567-73.
11. Макиева М.И., Матвеева Н.К., Ванько Л.В., Цой Т.А., Жукова А.С., Шаталова Е.А., Полушкина Е.С., Аверьянова М.В., Тимофеева Л.А., Кречетова Л.В., Зубков В.В., Шмаков Р.Г. Клинико-иммунологическая характеристика новорожденных у матерей с онкологическими заболеваниями. Акушерство и гинекология. 2017; 11: 92-9. https://dx.doi.org/10.18565/aig.2017.11.92-99 [Makieva M.I., Matveeva N.K., Vanko L.V., Tsoi T.A., Zhukova A.S., Shatalova E.A., Polushkina E.S., Averyanova M.V., Timofeeva L.A., Krechetova L.V., Zubkov V.V., Shmakov P.G. Clinical and immunological characteristics of newborn infants from mothers with cancers. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (11): 92-9. (in Russian) https://dx.doi.org/10.18565/aig.2017.11.92-99]
12. Волочаева М.В., Шмаков Р.Г., Зубков В.В. Здоровье детей, рожденных женщинами с раком молочной железы, связанным с беременностью. Акушерство и гинекология. 2014; 7: 33-7. [Volochaeva M.V., Shmakov R.G., Zubkov V.V. The health of babies born to women with pregnancy-associated breast cancer. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2014; (7): 33-7. (in Russian)]
13. Шахтарина С.В., Даниленко А.А., Щелконогова Л.Н., Павлов В.В. Беременность, роды и состояние здоровья детей, родившихся у женщин с лимфомой Ходжкина после лучевого или комбинированного химиолучевого лечения. Клиническая онкогематология. 2012; 5(3): 218-23. [Shakhtarina S.V., Danilenko A.A., Shchelkonogova L.N., Pavlov V.V. Pregnancy, childbirth and health of children born to women with Hodgkin’s lymphoma after radiation or combined chemoradiotherapy. Klinicheskaya onkogematologiya. 2012; 5(3): 218-23. (in Russian)]
14. Yang J., Richmond A. The angiostatic activity of interferon-indusible protein-10/CXCL10 in human melanoma depends on binding to CXCR3 but not to glycosaminoglycan. Mol. Ther. 2004; 9(6): 846-55.
Received 14.12.2017
Accepted 22..12.2017
About the Authors
Zhukova, Anastasiya S., research worker in Laboratory of clinical immunology, National Medical Research Center of Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954381183. E-mail: a_belyaeva@oparina4.ruMakieva, Mziya I., neonatologist, pediatrician, the Head of the clinical work of the Department of newborns, National Medical Research Center of Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74955314444. Е-mail: m_makieva@oparina4.ru
Vanko, Lyudmila V., Doctor of Medicine, professor, leading research worker in Laboratory of clinical immunology, National Medical Research Center of Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954381183. E-mail: lvanko@mail.ru.
Vtorushina, Valentina V., PhD in medical sciences, doctor of laboratory diagnostics in Laboratory of Clinical Immunology, National Medical Research Center of Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954381183. E-mail: vtorushina@inbox.ru
Matveeva, Natalia K., PhD in biological sciences, senior researcher in Laboratory of clinical immunology, National Medical Research Center of Obstetrics,
Gynecology and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954381183. E-mail: matveeva_nk@mail.ru.
Tsoy, Tatiana A., neonatologist of the Department of newborns, National Medical Research Center of Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954382610. Е-mail: t_tsoy@oparina4.ru
Volochaeva, Maria V., PhD in medical sciences, obstetrician-gynecologist of the obstetric department of physiological, National Medical Research Center of Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954380777. E-mail: m_volochaeva@oparina4.ru
Timofeeva, Leila A., PhD in medical sciences, the Head of the Department of newborns, National Medical Research Center of Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954380883. Е-mail: l_timofeeva@oparina4.ru
Krechetova, Lyudmila V., PhD in medical sciences, the Head of Laboratory of clinical immunology, National Medical Research Center of Obstetrics,
Gynecology and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954381183. E-mail: k_l_v_@mail.ru.
Zubkov, Viktor V., Doctor of Medicine, the Head of the Department of Neonatology and Pediatrics, National Medical Research Center of Obstetrics,
Gynecology and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954382266. E-mail: v_zubkov@oparina4.ru
Shmakov, Roman G., Doctor of Medicine, Head Physician of National Medical Research Center of Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954387200. E-mail: r_shmakov@oparina4.ru
For citations: Zhukova A.S., Makieva M.I., Vanko L.V., Vtorushina V.V., Matveeva N.K., Tsoi T.A., Volochaeva M.V., Timofeeva L.A., Krechetova L.V., Zubkov V.V., Shmakov R.G. Blood cytokine levels in neonates born to mothers with cancer who received antitumor chemotherapy during pregnancy. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (8): 136-42. (in Russian)
https://dx.doi.org/10.18565/aig.2018.8.136-142
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