A case of the rapid course of the novel coronavirus infection (COVID-19) in a pregnant woman

Bezhenar V.F., Zazerskaya I.E., Kucheryavenko A.N., Meshchyaninova S.G., Mazurok V.A., Rzheutskaya R.E., Godzoeva A.О.

1) Academician I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of the Russian Federation, Saint Petersburg, Russian Federation; 2) V.A. Almazov National Medical Research Center, Ministry of Health of the Russian Federation, Saint Petersburg, Russian Federation; 3) S.P. Botkin Clinical Infectious Diseases Hospital, Saint Petersburg, Russian Federation
The novel coronavirus infection is a global pandemic with a continuing upward trend for global cases. The virus can infect any person; however, pregnant women may be more susceptible due to physiological changes in the body. This paper describes a clinical case of the rapid course of COVID-19 pneumonia in a pregnant patient without substantial risk factors for a severe, complicated form of the disease. Patient Zh. was infected with COVID-19 at 37-38 weeks’ gestation. The first clinical manifestations of the disease were sore throat accompanied by a rise in temperature up to 38° C. Taking into consideration that the patient felt worse, cough and fever appeared, she was admitted to a specialized hospital on day 5 after the onset of the disease. On day 7 of hospitalization, worsening respiratory symptoms and intoxication syndrome led to the development of acute cardiopulmonary failure that was the cause of death in the pregnant woman and her fetus. Despite the relatively small number of maternal deaths due to COVID-19, obstetricians/gynecologists and other health care workers need additional data on the characteristics of the course of the disease and possible adverse maternal and perinatal outcomes.
Conclusion. Physicians should be informed about mortality and its associated clinical characteristics in patients mainly because the median time from the onset of symptoms of the infectious process to the fatal outcome can be as little as two weeks.

Keywords

coronavirus infections (COVID-19)
pregnancy
pregnancy complications
fatal outcome

References

  1. COVID-19 worldwide number of cases: Coronavirus update (Live). Available at: https://www.worldometers.info/coronavirus/?
  2. Liu H., Wang L.L., Zhao S.J., Kwak-Kim J., Mor G., Liao A.H. Why are pregnant women susceptible to COVID-19? An immunological viewpoint. J. Reprod. Immunol. 2020; 139: 103122. https://dx.doi.org/10.1016/j.jri.2020.103122.
  3. Moore C.A., Staples J.E., Dobyns W.B., Pessoa A., Ventura C.V., Da Fonseca E.B. et al. Characterizing the pattern of anomalies in congenital Zika syndrome for pediatric clinicians. JAMA Pediatr. 2017; 171(3): 288-95. https://dx.doi.org/10.1001/jamapediatrics.2016.3982.
  4. Siston A.M., Rasmussen S.A., Honein M.A., Fry A.M., Seib K., Callaghan W.M. Pandemic 2009 influenza a(H1N1) virus illness among pregnant women in the United States. JAMA. 2010; 303(15): 1517-25. https://dx.doi.org/10.1001/jama.2010.479.
  5. Dashraath P., Wong J.L.J., Lim M.XK., Lim L.M., Li S., Biswas A. et al. Coronavirus disease 2019 (COVID-19) pandemic and pregnancy. Am. J. Obstet. Gynecol. 2020; 222(6): 521-31. https://dx.doi.org/10.1016/j.ajog.2020.03.021.
  6. World Health Organisation Interim guidance: Clinical management of severe acute respiratory infection (SARI) when COVID‐19 disease is suspected. V1.2. 21 April 2020. Available at: https://www.who.int/publications‐detail/clinical‐management‐of‐severe‐acute‐respiratory‐infection‐when‐novel‐coronavirus‐(ncov)‐infection‐is‐suspected
  7. Pierce-Williams R.A.M., Burd J., Felder L., Khoury R., Bernstein P.S., Avila K. et al. Clinical course of severe and critical COVID‐19 in hospitalized pregnancies: a US cohort study. Am. J. Obstet. Gynecol. MFM. 2020; 2(3): 100134. https://dx.doi.org/10.1016/j.ajogmf.2020.100134.
  8. Hessami K., Homayoon N., Hashemi A., Vafaei H., Kasraeian M., Asadi N. COVID-19 and maternal, fetal and neonatal mortality: a systematic review. J. Matern. Fetal Neonatal Med. 2020 Aug 16; 1-6. https://dx.doi.org/10.1080/14767058.2020.1806817.
  9. Prisco D., Ciuti G., Falciani M. Hemostatic changes in normal pregnancy. Hematol. Meet. Reports (Formerly Haematol. Reports). 2009; 1(10): 1-5.
  10. Van der Poll T., Levi M. Crosstalk between inflammation and coagulation: the lessons of sepsis. Curr. Vasc. Pharmacol. 2012; 10(5): 632-8. https://dx.doi.org/10.2174/157016112801784549.
  11. Version 11: updated 24 July 2020. Guidance for healthcare professionals on coronavirus (COVID-19) infection in pregnancy, published by the RCOG, Royal College of Midwives, Royal College of Paediatrics and Child Health, Public Health England and Public Health Scotland. Available at: https://www.rcog.org.uk/en/guidelines-research-services/guidelines/coronavirus-pregnancy/ Accessed 30.08.2020.
  12. Guidance for U.S. Healthcare facilities about coronavirus (COVID-19) updated July 12, 2020. The Centers for Disease Control and Prevention (CDC). Available at: https://www.cdc.gov/coronavirus/2019-ncov/hcp/us-healthcare-facilities.html Accessed 30.08.2020.
  13. Временные методические рекомендации «Профилактика, диагностика и лечение новой коронавирусной инфекции (COVID-19)». Версия 7 от 03.06.2020. Доступно по: https://www.rosminzdrav.ru/ministry/med_covid19 Ссылка активна на: 30.08.2020. [Temporary guidelines “Prevention, diagnosis and treatment of new coronavirus infection (COVID-19)” version 7 of 03.06.2020 (in Russian)].
  14. Методические рекомендации «Организация оказания медицинской помощи беременным, роженицам, родильницам и новорожденным при новой коронавирусной инфекции COVID-19». Версия 2 от 28.04.2020. Доступно по: https://www.rosminzdrav.ru/ministry/med_covid19 Ссылка активна на: 30.08.2020. [Methodological recommendations “Organization of medical care for pregnant women, women in labor, women in labor and newborns with a new coronavirus infection COVID-19” version 2 of 28.04.2020. (in Russian)].
  15. Методические рекомендации, алгоритмы действия медицинских работников на различных этапах оказания помощи, чек-листы и типовые документы, разработанные на период наличия и угрозы дальнейшего распространения новой коронавирусной инфекции в Санкт-Петербурге. Версия 3,0 от 22.06.2020. Доступно по http://zdrav.spb.ru/media/filebrowser/covid-19_22.06.pdf Ссылка активна на: 30.08.2020. [Methodological recommendations, algorithms for the actions of medical workers at various stages of care, checklists and standard documents developed for the period of the presence and threat of further spread of a new coronavirus infection in St. Petersburg, version 3.0 of 22.06.2020. (in Russian)].
  16. Краткие клинические рекомендации «Тактика ведения беременных, рожениц и родильниц с подозрением или подтвержденной инфекцией COVID-19». Версия 1,0 от 14.04.2020. СПб.; 2020. [Brief clinical recommendations “Management tactics for pregnant women, women in labor and women in labor with suspected or confirmed COVID-19 infection”, version 1.0 of 14.04.2020. St. Petersburg, 2020. (in Russian)].
  17. COVID-19 Treatment guidelines panel. Coronavirus disease 2019 (COVID-19) treatment guidelines. National Institutes of Health. Available at:https://www.covid19treatmentguidelines.nih.gov/
  18. Puntmann V.O., Carerj M.L., Wieters I., Fahim M., Arendt C., Hoffmann J. et al. Outcomes of cardiovascular magnetic resonance imaging in patients recently recovered from coronavirus disease 2019 (COVID-19). JAMA Cardiol. 2020; 5(11): 1265-73. https://dx.doi.org/10.1001/jamacardio.2020.3557.
  19. Lindner D., Fitzek A., Bräuninger H., Aleshcheva G., Edler C., Meissner K. et al. Association of cardiac infection with SARS-CoV-2 in confirmed COVID-19 autopsy cases. JAMA Cardiol. 2020; 5(11): 1281-5. https://dx.doi.org/10.1001/jamacardio.2020.3551.
  20. Yancy C.W., Fonarow G.C. Coronavirus disease 2019 (COVID-19) and the heart—is heart failure the next chapter? JAMA Cardiol. 2020; 5(11): 1216-7. https://dx.doi.org/10.1001/jamacardio.2020.3575.
  21. Psotka M.A., Ammon S.E., Fiuzat M., Bozkurt B., Chung E.S., Cole R.T. et al. Heart failure site-based research in the United States: Results of the heart failure Society of America Research Network Survey. JACC Heart Fail. 2019; 7(5): 431-8. https://dx.doi.org/10.1016/j.jchf.2019.02.008.

Received 03.09.2020

Accepted 12.11.2020

About the Authors

Vitaliy F. Bezhenar, MD, PhD, professor, Head of Obstetrics and Gynecology Department, I.P. Pavlov First Saint-Petersburg Medical University, Ministry of Health of Russian Federation; Chief expert in obstetrics and gynecology of Saint-Petersburg Healthcare Committee and Ministry of Health in North-Western Federal Region of Russian Federation. E-mail: bez-vitaly@yandex.ru. 197022, Russia, Saint Petersburg, L. Tolstoy str., 6-8.
Irina E. Zazerskaya, MD, PhD, Dr. Sci. (Medicine), the Head of Department of Obstetrics and Gynecology, V.A. Almazov National Medical Research Centre, Ministry of Health of the Russian Federation. Tel.: +7(921)948-83-40. Е-mail: zazera@mail.ru. 197341, Russia, Saint Petersburg, Akkuratova str., 2b.
Alexander N. Kucheryavenko, PhD, associate Professor, Deputy Chief Physician for obstetrics and gynecology, Botkin Clinical Infectious Diseases Hospital, Saint Petersburg.
195067, Russia, Saint Petersburg, Piskarevsky Prospekt, 49.
Svetlana G. Meshchaninova, MD, Head of the Department of anesthesiology and reanimatology, Botkin Clinical Infectious Diseases Hospital, Saint Petersburg.
195067, Russia, Saint Petersburg, Piskarevsky prospect, 49.
Vadim A. Mazurok, MD, PhD, Dr. Sci. (Medicine), Head of the Department of Anesthesiology and Reanimatology, V.A. Almazov National Medical Research Centre, Ministry of Health of the Russian Federation. Е-mail: vmazurok@mail.ru. 197341, Russia, Saint Petersburg, Akkuratova str., 2b.
Ryta E. Rzheutskaya, MD, PhD, associate Professor of the Department of Anesthesiology and Reanimatology, V.A. Almazov National Medical Research Centre, Ministry of Health of the Russian Federation. 197341, Russia, Saint Petersburg, Akkuratova str., 2b.
Alina O. Godzoeva, MD, Post-graduate student, Department of Obstetrics and Gynecology, V.A. Almazov National Medical Research Centre, Ministry of Health of the Russian Federation. Tel.: +7(988)870-86-76. Е-mail: godzoevaalina@mail.ru. 197341, Russia, Saint Petersburg, Akkuratova str., 2b.

For citation: Bezhenar V.F., Zazerskaya I.E., Kucheryavenko A.N., Meshchyaninova S.G., Mazurok V.A., Rzheutskaya R.E., Godzoeva A.О. A case of the rapid course of the novel coronavirus infection (COVID-19) in a pregnant woman.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2021; 1: 186-193 (in Russian)
https://dx.doi.org/10.18565/aig.2021.1.186-193

Similar Articles

By continuing to use our site, you consent to the processing of cookies that ensure the proper functioning of the site.