Systematic review of the efficacy and safety of nifuratel for patients with lower urinary tract infection

DOI

https://dx.doi.org/10.18565/aig.2021.6.168-176

Kasyan V.N., Zaitsev A.V., Perepanova T.S., Pivazyan L.G., Grigoryan B.L., Kupriyanov Yu.A. Kasyan G.R., Pushkar D.Yu.
1) A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow, Russia; 2) N.A. Lopatkin Research Institute of Urology and Interventional Radiology, Branch, National Medical Radiology Research Center, Ministry of Health of Russia, Moscow, Russia; 3) I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), Moscow, Russia

Objective. To investigate the clinical and bacteriological efficacy of nifuratel in the therapy of urinary tract infections.
Materials and methods. This systematic review includes all studies published in English and Russian for the period 1969–2020 that assessed the effectiveness of nifuratel in the treatment of lower urinary tract infections (LUTI) in women, including pregnant women. The review was written using the PRISMA checklist. The analysis involved randomized and nonrandomized original clinical trials (prospective controlled, prospective cohort, retrospective studies, etc.) and case series studies that included at least 10 patients.
Results. After searching for and excluding duplicates, 192 publications were included in the screening, of which 169 ones were excluded by reviewing the title and abstract. A total of 9 studies were obtained for qualitative synthesis, 7 of them were clinical ones that included the analysis of 442 patients.
Conclusion. The systematic review shows that the efficacy of nifuratel as a drug for the therapy of urinary tract infections is comparable and sometimes superior to that of other antibiotics. Nifuratel shows more pronounced therapeutic efficacy and better tolerability compared to nitrofurantoin. Today, it is impossible to consider LUTI in women in isolation and not take into account the state of biocenosis of the vagina and intestines. Nifuratel is also interesting in that it has a spectrum of activity not only with respect to the main uropathogens, but also the causative agents of individual vaginal infections and is suitable for the treatment of acute and chronic LUTI. However, there remains a need to conduct a large number of randomized controlled trials, as well as to examine the safety profile for renal failure and in the elderly.

cystitis

nifuratel

treatment

systematic review

Makmiror

Full text (in Russian)

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Received 15.06.2021

Accepted 17.06.2021

Victoria N. Kasyan, Ph.D., associate professor of the Department of Reproductive Medicine and Surgery, A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia. 127206, Russia, Moscow, Vuchetich str., 21.
Andrei V. Zaitsev, Dr. Med. Sci., Professor of the Department of Urology, A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia. E-mail: zaitcevandrew@mail.ru. 127206, Russia, Moscow, Vuchetich str., 21.
Tamara S. Perepanova, Dr. Med. Sci., Professor, Head of the Group of Infectious and Inflammatory Diseases and Clinical Pharmacology of the Department of General and Reconstructive Urology, N.A. Lopatkin Research Institute of Urology and Interventional Radiology. E-mail: perepanova2003@mail.ru. ORCID: 0000-0002-2877-0029; eLibrary SPIN 4153-9668. 105425, Russia, Moscow, str. Parkovaya 3rd, 51-1.
Laura G. Pivazyan, 5th year student, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), headman of the SNO Department of Obstetrics and Gynecology No. 1 PCM. E-mail: laurapivazyan98@gmail.com. ORCID: 0000-0002-6844-3321, eLibrary SPIN: 3949-2120.
19991, Russia, Moscow, Trubetskaya str., 8-2.
Bagrat L. Grigoryan, 5th year student, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University). E-mail: bagybaga97@gmail.com. ORCID: 0000-0002-7698-0653. 119991, Russia, Moscow, Trubetskaya str., 8-2.
Yuri A. Kupriyanov, Ph.D., assistant to the Department of Urology, A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia. E-mail: dr.kupriyanov@gmail.com. 127206, Russia, Moscow, Vuchetich str., 21.
Gevorg R. Kasyan, Dr. Med. Sci., Professor of the Department of Urology, Head of the Department of Functional Urology, A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia. E-mail: g.kasyan@outlook.com. ORCID: 0000-0001-7919-2217; Scopus Author ID: 55394998300; ResearcherID: M-4263-2014. 127206, Russia, Moscow, Vuchetich str., 21.
Dmitry Yu. Pushkar, Academician of the Russian Academy of Sciences, Professor, Head of the Department of Urology, A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia. E-mail: pushkardm@mail.ru. ORCID: 0000-0001-9935-3962; Author ID: 417122; elibrarySPIN: 8221-8306; elibraryScopus ID: 6603700507. 127206, Russia, Moscow, Vuchetich str., 21.

For citation: Kasyan V.N., Zaitsev A.V., Perepanova T.S., Pivazyan L.G., Grigoryan B.L., Kupriyanov Yu.A. Kasyan G.R., Pushkar D.Yu. Systematic review of the efficacy and safety of nifuratel for patients with lower urinary tract infection.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2021; 6: 168-176 (in Russian)
https://dx.doi.org/10.18565/aig.2021.6.168-176

Systematic review of the efficacy and safety of nifuratel for patients with lower urinary tract infection

Kasyan V.N., Zaitsev A.V., Perepanova T.S., Pivazyan L.G., Grigoryan B.L., Kupriyanov Yu.A. Kasyan G.R., Pushkar D.Yu.

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