Lymphoepithelioma-like carcinoma of the cervix
Background: Lymphoepithelioma-like carcinoma of the cervix is one of the subtypes of squamous cell carcinoma of the cervix (CC). Taking into consideration the lack of information about this malignant lesion, publishing the experience of diagnosing and treating a rare variant of CC based on morphologically confirmed echographic data is of interest for practical gynecological oncology.Rymashevsky A.N., Volkov A.E., Voloshin V.V., Todorov S.S., Berlev I.V., Borshchenko I.N.
Case report: A 41-year-old patient having acyclic profuse bloody vaginal discharge for 3 months underwent transvaginal echography revealing that the subepithelial tissue of the cervix showed a hypoechoic, homogeneous nodular structure with clear, even contours, 10×11×14 mm with intense low-velocity blood flow in the center and around the periphery. Extended colposcopy indicated no abnormal changes. MRI confirmed the presence of an endophytic tumor in the cervix without invasion into the vagina, parametria, bladder, rectum, and regional lymph nodes. Radiowave excision of the cervix removed a tumor growing into the endometrium, which was identified as a lymphoepithelial-like carcinoma. Taking into account the malignant nature of the tumor, the investigators performed laparoscopic nerve-sparing radical extirpation of the uterus with fallopian tubes, parametria, and the upper third of the vagina, as well as pelvic lymphadenectomy, and ovarian transposition. The postoperative follow-up is 9 months. The patient’s condition is satisfactory.
Conclusion: In the absence of CC manifestations in the exocervix, transvaginal echography is deemed as a diagnostic tool to detect potentially malignant lesions, rare forms of CC in particular.
Keywords
cervical cancer
lymphoepithelioma-like carcinoma of the cervix
diagnosis
treatment
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Received 05.08.2022
Accepted 13.10.2022
About the Authors
Alexander N. Rymashevsky, Dr. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology No. 1, Rostov State Medical University, Ministry of Healthof Russia, 344022, Russia, Rostov-on-Don, Nakhichevan lane, 29, +7(863)234-24-23, rymashevskyan@mail.ru, https://orcid.org/0000-0003-3349-6914
Andrey E. Volkov, PhD, Associate Professor, Department of Obstetrics and Gynecology No. 1, Rostov State Medical University, Ministry of Health of Russia,
344022, Russia, Rostov-on-Don, Nakhichevan lane, 29, +7(863)234-24-23, avolkov@aaanet.ru, https://orcid.org/ 0000-0002-5899-1252
Vladimir V. Voloshin, PhD, Associate Professor, Department of Pathological Anatomy, Rostov State Medical University, Ministry of Health of Russia,
344022, Russia, Rostov-on-Don, Nakhichevan lane, 29; +7(863)234-24-23, voloshinvv2006@yandex.ru, https://orcid.org/0000-0001-8632-082X
Sergey S. Todorov, Dr. Med. Sci., Associate Professor, Head of the Department of Pathological Anatomy, Rostov State Medical University, Ministry of Health of Russia, 344022, Russia, Rostov-on-Don, Nakhichevan lane, 29, +7(863)201-44-31, kafedrapatan@mail.ru, https://orcid.org/0000-0001-8467-5606
Igor V. Berlev, Dr. Med. Sci., Professor, Honored Doctor of the Russian Federation, Head of the Department of Oncogynecology, NMRC named after N.N. Petrov,
Ministry of Health of Russia, 197758, Russia, St. Petersburg, Pesochny village, Leningradskaya str., 68; Head of the Department of Obstetrics and Gynecology, I.I. Mechnikov S-WMU, Ministry of Health of Russia, 191015, Russia, Saint Petersburg, Kirochnaya str., 41, iberlev@gmail.com, SPIN code: 4169-6011,
Autor ID: 668976, Scopus AuthorID: 6603322008
Irina N. Borshchenko, intern, Department of Obstetrics and Gynecology No.1, Rostov State Medical University, Ministry of Health of Russia,
344022, Russia, Rostov-on-Don, Nakhichevan lane, 29, +7(863)234-24-23, irinaborshchenko999@gmail.com
Corresponding author: Andrey E. Volkov, avolkov@aaanet.ru
Authors’ contributions: Rymashevsky A.N. – concept and design of the investigation, scientific editing of the text;
Volkov A.E. – development of the design of the investigation, obtaining the data to be analyzed, their analysis and interpretation, writing the text of the article; Voloshin V.V., Todorov S.S. – morphological examinations, editing the findings, writing the text; Berlev I.V. – surgical treatment of patients, editing the text; Borshchenko I.N. – technical processing of the findings, work with literature sources.
Conflicts of interest: The authors declare that there are no conflicts of interest.
Funding: The investigation has not been sponsored.
Patient Consent for Publication: The patient has signed an informed consent form to the publication of her data and associated images.
For citation: Rymashevsky A.N., Volkov A.E., Voloshin V.V., Todorov S.S.,
Berlev I.V., Borshchenko I.N. Lymphoepithelioma-like carcinoma of the cervix.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2022; 11: 180-186 (in Russian)
http://dx.doi.org/10.18565/aig.2022.11.180-186
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