Synergy between folates and docosahexaenoic acid when taking the micronutrients separately during pregnancy

1. Громова О.А., Торшин И.Ю., Авдеева Н.В., Спиричев В.Б. Применение витаминов и микроэлементов у беременных в разных странах. Вопросы гинекологии, акушерства и перинатологии. 2011; 10(5): 62-71. [Gromova O.A., Torshin I.Yu., Avdeeva N.V., Spirichev V.B. The use of vitamins and trace elements in pregnant women in different countries. Voprosyi ginekologii, akusherstva i perinatologii. 2011; 10(5): 62-71. (in Russian)]

2. Громова О.А., Торшин И.Ю., Лисицына Е.Ю. Гепатопротекторные свойства витаминов в преконцепции и при беременности. Земский врач. 2011; 4: 23-8. [Gromova O.A., Torshin I.Yu., Lisitsyna E.Yu. Hepatoprotective properties of vitamins in preconception and pregnancy. Zemsky vrach. 2011; 4: 23-8. (in Russian)]

3. Greenberg J.A., Bell S.J., Guan Y., Yu Y.H. Folic acid supplementation and pregnancy: more than just neural tube defect prevention. Rev. Obstet. Gynecol. 2011; 4(2): 52-9.

4. Dary O. Nutritional interpretation of folic acid interventions. Nutr. Rev. 2009; 67(4): 235-44.

5. Торшин И.Ю., Громова О.А.; РСЦ Ин-та микроэлементов ЮНЕСКО. 25 мгновений молекулярной фармакологии. О развитии клинико-фармакологического мышления. Монография. Иваново; 2012. [Torshin I.Yu., Gromova O.A.; RIC of the UNESCO Institute for Micronutrients. 25 Moments of Molecular Pharmacology. On the development of clinical and pharmacological thinking. Monograph. Ivanovo; 2012. (in Russian)]

6. Серов В.Н., Торшин И.Ю., Громова О.А. Потриместровый подход к назначению витаминно-минеральных комплексов на основе систематического анализа биологической значимости витаминов и микроэлементов в системе мать-плацента-плод. Гинекология. 2010; 12(6): 24-34. [Serov V.N., Torshin I.Yu., Gromova O.A. Postmestrial approach to the appointment of vitamin-mineral complexes based on a systematic analysis of the biological importance of vitamins and trace elements in the mother-placenta-fetus system. Ginekologiya. 2010; 12(6): 24-34. (in Russian)]

7. Громова О.А., Торшин И.Ю., Тетруашвили Н.К., Сидельникова В.М. Нутрициальный подход к профилактике избыточной массы тела новорожденных. Гинекология. 2010; 12(5): 56-64. [Gromova O.A., Torshin I.Yu., Tetruashvili N.K., Sidelnikova V.М. Nutritsialny approach to the prevention of overweight of newborns. Ginekologiya. 2010; 12 (5): 56-64. (in Russian)]

8. Simopoulos A.P. The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Exp. Biol. Med. (Maywood). 2008; 233(6): 674-88.

9. Громова О.А., Торшин И.Ю., Егорова Е.Ю. Омега-3 полиненасыщенные жирные кислоты и когнитивное развитие детей. Вопросы современной педиатрии. 2011; 10(1): 66-72. [Gromova O.A., Torshin I.Yu., Egorova E.Yu. Omega-3 polyunsaturated fatty acids and cognitive development of children. Voprosyi sovremennoy pediatrii. 2011; 10(1): 66-72. (in Russian)]

10. Koppelmann T., Pollak Y., Mogilner J., Bejar J., Coran A.G., Sukhotnik I. Reversal of severe methotrexate-induced intestinal damage using enteral n-3 fatty acids. Br. J. Nutr. 2013; 109(1): 89-98.

11. Serhan C.N. Novel eicosanoid and docosanoid mediators: resolvins, docosatrienes, and neuroprotectins. Curr. Opin. Clin. Nutr. Metab. Care. 2005; 8(2): 115-21.

12. Mukherjee P.K., Marcheselli V.L., Serhan C.N., Bazan N.G. Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress. Proc. Natl. Acad. Sci. USA. 2004; 101(22): 8491-6.

13. Bazan N.G. Omega-3 fatty acids, pro-inflammatory signaling and neuroprotection. Curr. Opin. Clin. Nutr. Metab. Care. 2007; 10(2): 136-41.

14. Hashimoto M., Tanabe Y., Fujii Y., Kikuta T., Shibata H., Shido O. Chronic administration of docosahexaenoic acid ameliorates the impairment of spatial cognition learning ability in amyloid beta-infused rats. J. Nutr. 2005; 135(3): 549-55.

15. Belayev L., Khoutorova L., Atkins K.D., Eady T.N., Hong S., Lu Y. et al. Docosahexaenoic acid therapy of experimental ischemic stroke. Transl. Stroke Res. 2011; 2(1): 33-41.

16. Belayev L., Khoutorova L., Atkins K.D., Bazan N.G. Robust docosahexaenoic acid-mediated neuroprotection in a rat model of transient, focal cerebral ischemia. Stroke. 2009; 40(9): 3121-6.

17. Громова О.А., Торшин И.Ю., Сонина Н.П., Керимкулова Н.В. Cколько нужно назначать омега-3 пнжк беременной? О профилактической, лечебной и избыточной дозе. О дозировании омега-3 пнжк при соматической и акушерской патологии. Вопросы эффективности и безопасности. Земский врач. 2013; 3: 39-46. [Gromova O.A., Torshin I.Yu., Sonina N.P., Kerimkulova N.V. How often should I prescribe omega-3 pregnant women? About the preventive, curative and excessive dose. About dosing of omega-3 pnzhk in somatic and obstetrical pathology. Issues of efficiency and safety. Zemsky vrach. 2013; 3: 39-46. (in Russian)]

18. McNamara R.K., Able J., Jandacek R., Rider T., Tso P., Eliassen J.C. et al. Docosahexaenoic acid supplementation increases prefrontal cortex activation during sustained attention in healthy boys: a placebo-controlled, dose-ranging, functional magnetic resonance imaging study. Am. J. Clin. Nutr. 2010; 91(4): 1060-7.

19. Durand P., Prost M., Blache D. Pro-thrombotic effects of a folic acid deficient diet in rat platelets and macrophages related to elevated homocysteine and decreased n-3 polyunsaturated fatty acids. Atherosclerosis. 1996; 121(2): 231-43.

20. Sugiyama K., Kumazawa A., Zhou H., Saeki S. Dietary methionine level affects linoleic acid metabolism through phosphatidylethanolamine N-methylation in rats. Lipids. 1998; 33(3): 235-42.

21. Devlin A.M., Singh R., Wade R.E., Innis S.M., Bottiglieri T., Lentz S.R. Hypermethylation of Fads2 and altered hepatic fatty acid and phospholipid metabolism in mice with hyperhomocysteinemia. J. Biol. Chem. 2007; 282(51): 37082-90.

22. Kulkarni A., Dangat K., Kale A., Sable P., Chavan-Gautam P., Joshi S. Effects of altered maternal folic acid, vitamin B12 and docosahexaenoic acid on placental global DNA methylation patterns in Wistar rats. PLoS One. 2011; 6(3): e17706.

23. Clarke S.D. Polyunsaturated fatty acid regulation of gene transcription: a molecular mechanism to improve the metabolic syndrome. J. Nutr. 2001; 131(4): 1129-32.

24. Huang T., Wahlqvist M.L., Li D. Effect of n-3 polyunsaturated fatty acid on gene expression of the critical enzymes involved in homocysteine metabolism. Nutr. J. 2012; 11: 6.

25. Vedin I., Cederholm T., Freund-Levi Y., Basun H., Garlind A., Irving G.F. et al. Effects of DHA-rich n-3 fatty acid supplementation on gene expression in blood mononuclear leukocytes: the OmegAD study. PLoS One. 2012; 7(4): e35425.

26. Jansson T., Powell T.L. Role of the placenta in fetal programming: underlying mechanisms and potential interventional approaches. Clin. Sci. 2007; 113: 1-13.

27. Hovdenak N., Haram K. Influence of mineral and vitamin supplements on pregnancy outcome. Eur. J. Obstet. Gynecol. Reprod. Biol. 2012;164(2): 127-32.

28. Fowden A.L., Forhead A.J., Coan P.M., Burton G.J. The placenta and intrauterine programming. J. Neuroendocrinol. 2008; 20: 439-50.

29. Klingler M., Blaschitz A., Campoy C., Cano A., Molloy A.M., Scott J.M. et al. The effect of docosahexaenoic acid and folic acid supplementation on placental apoptosis and proliferation. Br. J. Nutr. 2006; 96(1): 182-90.

30. Agostoni C., Nobile M., Ciappolino V., Delvecchio G., Tesei A., Turolo S. et al. The role of Omega-3 fatty acids in developmental psychopathology: a systematic review on early psychosis, autism, and ADHD. Int. J. Mol. Sci. 2017; 18(12). pii: E2608.

31. Peet M. Eicosapentaenoic acid in the treatment of schizophrenia and depression: rationale and preliminary double-blind clinical trial results. Prostaglandins Leukot. Essent. Fatty Acids. 2003; 69(6): 477-85.

32. Applebaum J., Shimon H., Sela B.A., Belmaker R.H., Levine J. Homocysteine levels in newly admitted schizophrenic patients. J. Psychiatr. Res. 2004; 38(4): 413-6.

33. Escolano-Margarit M.V., Ramos R., Beyer J., Csabi G., Parrilla-Roure M., Cruz F. et al. Prenatal DHA status and neurological outcome in children at age 5.5 years are positively associated. J. Nutr. 2011; 141(6): 1216-23.

34. Campoy C., Escolano-Margarit M.V., Ramos R., Parrilla-Roure M., Csabi G., Beyer J. et al. Effects of prenatal fish-oil and 5-methyltetrahydrofolate supplementation on cognitive development of children at 6.5 y of age. Am. J. Clin. Nutr. 2011; 94(6,Suppl.): 1880S-8S.

35. Sinclair A.J., Begg D., Mathai M., Weisinger R.S. Omega 3 fatty acids and the brain: review of studies in depression. Asia Pac. J. Clin. Nutr. 2007; 16(Suppl.1): 391-7.

36. Mazahery H., Stonehouse W., Delshad M., Kruger M., Conlon C., Beck K., von Hurst P. Relationship between long chain n-3 polyunsaturated fatty acids and autism spectrum disorder: systematic review and meta-analysis of case-control and randomised controlled trials. Nutrients. 2017; 9: 155.

37. Freedman R., Hunter S.K., Hoffman M.C. Prenatal primary prevention of mental illness by micronutrient supplements in pregnancy. Am. J. Psychiatry. 2018; 175(7): 607-19.

38. Degroote S., Hunting D., Takser L. Periconceptional folate deficiency leads to autism-like traits in Wistar rat offspring. Neurotoxicol. Teratol. 2018; 66: 132-8.

39. Levine S.Z., Kodesh A., Viktorin A., Smith L., Uher R., Reichenberg A., Sandin S. Association of maternal use of folic acid and multivitamin supplements in the periods before and during pregnancy with the risk of autism spectrum disorder in offspring. JAMA Psychiatry. 2018; 75(2): 176-84.

40. Saghazadeh A., Ahangari N., Hendi K., Saleh F., Rezaei N. Status of essential elements in autism spectrum disorder: systematic review and meta-analysis. Rev. Neurosci. 2017; 28(7): 783-809.

41. Lebold K.M., Kirkwood J.S., Taylor A.W., Choi J., Barton C.L., Miller G.W. et al. Novel liquid chromatography-mass spectrometry method shows that vitamin E deficiency depletes arachidonic and docosahexaenoic acids in zebrafish (Danio rerio) embryos. Redox Biol. 2013; 2: 105-13.

42. Figueiredo C.P., Bicca M.A., Latini A., Prediger R.D., Medeiros R., Calixto J.B. Folic acid plus α-tocopherol mitigates amyloid-β-induced neurotoxicity through modulation of mitochondrial complexes activity. J. Alzheimers Dis. 2011; 24(1): 61-75.

43. Gumpricht E., Rockway S. Can ω-3 fatty acids and tocotrienol-rich vitamin E reduce symptoms of neurodevelopmental disorders? Nutrition. 2014;30(7-8): 733-8.

44. Чегус Л.А., Корчин В.И., Корчина Т.Я. Корреляция показателей углеводно-липидного обмена и элементного статуса у женщин с макросомией плода, проживающих на Севере. Экология человека. 2018; 1: 41-6. [Chegus L.A., Korchin V.I., Korchina T.Ya. Correlation of carbohydrate-lipid metabolism and elemental status in women with fetal macrosomia living in the North. Ekologiya cheloveka. 2018; 1: 41-6. (in Russian)]

45. Керимкулова Н.В., Торшин И.Ю., Гришина Т.Р., Громов А.Н., Гоголева И.В., Громова О.А. Фармакоэкономический анализ витаминно-минеральных комплексов и препаратов отдельных микронутриентов для нутрициальной поддержки беременности. Мать и дитя в Кузбассе. 2014; 1: 30-40. [Kerimkulova N.V., Torshin I.Yu., Grishina T.R., Gromov A.N., Gogoleva I.V., Gromova O.A. Pharmacoeconomic analysis of vitamin-mineral complexes and preparations of individual micronutrients for nutritional support of pregnancy. Mother and child in Kuzbass. 2014; 1: 30-40. (in Russian)]

46. Yessoufou A., Nekoua M.P., Gbankoto A., Mashalla Y., Moutairou K. Beneficial effects of omega-3 polyunsaturated Fatty acids in gestational diabetes: consequences in macrosomia and adulthood obesity. J. Diabetes Res. 2015; 2015: 731434.

47. Громова О.А., Торшин И.Ю., Кошелева Н.Г. Молекулярные синергисты йода: новые подходы к эффективной профилактике и терапии йод-дефицитных заболеваний у беременных. РМЖ. 2011; 19(1): 51-8. [Gromova O.A., Torshin I.Yu., Kosheleva N.G. Molecular synergists of iodine: new approaches to effective prevention and treatment of iodine-deficient diseases in pregnant women. Russian Medical Journal. 2011; 19(1): 51-8. (in Russian)]

48. Yang J., Liu Y., Liu H., Zheng H., Li X., Zhu L., Wang Z. Associations of maternal iodine status and thyroid function with adverse pregnancy outcomes in Henan Province of China. J. Trace Elem. Med. Biol. 2018; 47: 104-10.

49. Нормы физиологических потребностей в энергии и пищевых веществах для различных групп населения Российской Федерации. Методические рекомендации 2.3.1.2432-08. М.; 2008. [Norms of physiological needs in energy and nutrients for various groups of the population of the Russian Federation. Methodical recommendations 2.3.1.2432-08. Moscow; 2008. (in Russian)]

50. Хотимченко С.А., Погожева А.В., Коденцова В.М., Кочеткова А.А., Пырьева Е.А. О применении витаминно-минеральных комплексов (ВМК) в лечебном питании. Методические рекомендации ФГБУН «Федеральный центр питания и биотехнологий». М.; 2017. [Khotimchenko S.A., Pogozheva A.V., Kodentsova V.M., Kochetkova A.A., Pyrieva E.A. On the use of vitamin-mineral complexes (IUD) in medical nutrition. Methodical recommendations FGBUN Federal Center for Nutrition and Biotechnology. Moscow; 2017. (in Russian)]

Received 08.06.2018

Accepted 22.06.2018