Role of pro- and contrinsular factors in the development of obstetric pathology
Objective. To investigate the effects of pro- and contrinsular proteins in women with metabolic syndrome and in those with normal metabolism on the development of obstetric pathology.Linde V.A., Palieva N.V., Botasheva T.L., Avrutskaya V.V., Dudareva M.V.
Subjects and methods. The prospective case-control study used an enzyme immunoassay technique to determine the serum levels of pro- and contrinsular factors (insulin-like growth factor-1, insulin-like growth factor-1 binding protein, receptor for glycation end products, and retinol-binding protein-4) in 150 patients with metabolic syndrome and 143 women with normal metabolism over time (1-3 trimesters). For data analysis, the investigators used descriptive statistics procedures that were employed to estimate the median values and interquartile ranges (25% to 75%). The significance level was set to be equal to 0.05.
Results and discussion. In patients with preeclampsia in the presence of metabolic syndrome, the values of insulin-like growth factor-1 were established to progressively increase by the third trimester, which were significantly higher than in women with physiological pregnancy and in those with normal metabolism. At the same time, the levels of the receptor of glycation end products were, on the contrary, significantly higher in the examinees with normal metabolism and uncomplicated pregnancy. The findings are suggestive of the initiation of insulin resistance in women with metabolic syndrome in the early pregnancy periods and of endothelial dysfunction that is most obvious in patients with preeclampsia.
Conclusion. Pregnant women with metabolic syndrome develop insulin resistance just in the first trimester. The decreased level of receptors for glycation end products in pregnant women with metabolic syndrome indicates the development of endothelial dysfunction that is most pronounced in patients with preeclampsia.
Keywords
pregnancy
metabolic syndrome
preeclampsia
proinsular and contrinsular factors
Supplementary Materials
- Table 1 – Content of pro- and contrainsular factors in blood serum of pregnant women with the metabolic syndrome and normal metabolism
- Table 2 – Content of pro- and contrainsular factors in blood serum of patients with the metabolic syndrome and normal metabolism depending on the course of pregnancy
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Received 28.06.2016
Accepted 02.09.2016
About the Authors
Viktor Anatolievich Linde, Professor, Doctor of Medicine, Director of Rostov Research Institute of Obstetrics and Pediatrics, Ministry of Health of Russia.344012, Russia, Rostov-on-Don, Mechnikova str. 43. Tel.: +78632903323. E-mail: vik-linde@yandex.ru
Natalia Viktorovna Palieva, Candidate of Medical Sciences, Academic Secretary of Rostov Research Institute of Obstetrics and Pediatrics, Ministry of Health of Russia.
344012, Russia, Rostov-on-Don, Mechnikova str. 43. Tel.: +79282964696. E-mail: nat-palieva@yandex.ru
Tatiana Leonidovna Botasheva, Professor, Doctor of Medicine, Head of the Female Physiology Laboratory, Chief Researcher of the Obstetrics and Gynecology Department, Rostov Research Institute of Obstetrics and Pediatrics, Ministry of Health of Russia.
344012, Russia, Rostov-on-Don, Mechnikova str. 43. Tel.: +78632009259, +79064248103. E-mail: t_botasheva@mail.ru
Valeria Viktorovna Avrutskaya, Doctor of Medicine, Chief Researcher of the Obstetrics and Gynecology Department, Rostov Research Institute of Obstetrics and Pediatrics, Ministry of Health of Russia. 344012, Russia, Rostov-on-Don, Mechnikova str. 43. Tel.: +78632674593, +78632275205. E-mail: V.Avrutskaya@rniiap.ru
Dudareva Maria Vasilievna, Doctor of Biology, the Head of the clinic- diagnostic laboratory, the leading research assistant of Department of medical and biologic problems in obstetrics and pediatrics, Rostov Research Institute of Obstetrics and Pediatrics, Ministry of Health of Russia.
344012, Russia, Rostov-on-Don, Mechnikova str. 43. Tel.: +79185559012. E-mail: m.dudareva@rniiap.ru
For citations: Linde V.A., Palieva N.V., Botasheva T.L., Avrutskaya V.V., Dudareva M.V. Role of pro- and contrinsular factors in the development of obstetric pathology.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (2): 32-8. (in Russian)
http://dx.doi.org/10.18565/aig.2017.2.32-8
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