Role of lipidomics in the development of complications of pregnancy
Objective. To carry out a systems analysis of the data available in the literature on lipid markers in the great obstetric syndromes.Ivanova O.O., Starodubtseva N.L., Shmakov R.G.
Materials and methods. The review includes the data of foreign and Russian articles published in the past 5 years and found in Pubmed and Scopus on studies of the great obstetric syndromes.
Results. The paper gives the main markers of the lipid profile in the great obstetric syndromes. The determination of serum lipidomics in a pregnant woman is promising in this area. But most studies were limited by a small sample size and no assessments of lipidomic alterations with disease progression. Therefore, further investigations are needed in this area, including the assessment of changes in the lipid profile over time in order to develop an individual pregnancy management approach in these abnormalities.
Conclusion. To improve outcomes for both the mother and the fetus, the new markers of the great obstetric syndromes are needed to be sought and introduced for their prediction and monitoring.
Keywords
early severe preeclampsia
late severe preeclampsia
hypertension
placental dysfunction
placental ischemia
lipidomics
phosphotidylserine
phosphatidylcholine
great obstetric syndromes
References
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Received 09.06.2017
Accepted 23.06.2017
About the Authors
Ivanova Olga Olegovna, post-graduate of the maternity ward, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia.117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79260210214. E-mail: lelia_tk@mail.ru
Shmakov Roman Georgievich, MD, Ph.D., chief physician, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954387300. E-mail: r_shmakov@oparina4.ru
Starodubtseva Natalia Leonidovna, Candidate of Biological Sciences, Head of the Laboratory of Proteomics and Metabolomics of Human Reproduction,
Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. E-mail: n_starodubtseva@oparina4.ru
For citations: Ivanova O.O., Starodubtseva N.L., Shmakov R.G. Role of lipidomics in the development of complications of pregnancy. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (4): 5-9. (in Russian)
https://dx.doi.org/10.18565/aig.2018.4.5-9
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