The problem of multiple pregnancy in the infertility treatment with assisted reproductive techniques

Papysheva E.I., Karaganova E.Yu., Breusenko L.E.

1) Department of Obstetrics and Gynecology, Faculty of Pediatrics, N.I. Pirogov Russian National Research Medical University, Ministry of Health, Moscow, Russia
Analysis of the results of studies presented in the international databases MedLine and EMBASE devoted to the problems of IVF-related multiple pregnancies has shown that the risk of complications in IVF pregnancies is higher than in spontaneous ones; the most promising and effective measures to reduce the risk of poor outcomes of IVF pregnancy are transfer of one good quality embryo and pregravid preparation prior to infertility treatment using assisted reproductive techniques.
Conclusion. The frequency of obstetric complications in IVF pregnancy remains an urgent task of modern reproductive medicine.

Keywords

embryo transfer
pregnancy
multiple pregnancy
risk
pregravid preparation

References

1. Kamphuis E.I., Bhattacharya S., van der Veen F., Mol B.W., Templeton A.; Evidence Based IVF Group. Are we overusing IVF? BMJ 2014; 348: g252.

2. Российская Ассоциация Репродукции Человека. Регистр ВРТ. Отчет за 2016 год. СПб.: Типография; 2018. 71с. [Russian Association of Human Reproduction. Register of ART. Report for 2016. SPb .: Typography; 2018. 71p. (in Russian)].

3. ESHRE Annual Report 2017. 29p. Available at: www.eshre.eu Accessed 25.08.2018.

4. Palomba S., Homburg R., Santagni S., La Sala G.B., Orvieto R. Risk of adverse pregnancy and perinatal outcomes after high technology infertility treatment: a comprehensive systematic review. Reprod. Biol. Endocrinol 2016; 14(1): 76. https://dx.doi.org/10.1186/s12958-016-0211-8.

5. Simon A., Laufer N. Assessment and treatment of repeated implantation failure (RIF). J. Assist. Reprod. Genet. 2012; 29(11): 1227-39.

6. American College of Obstetricians and Gynecologists; Society for Maternal-Fetal Medicine. ACOG Practice Bulletin No. 144: Multifetal gestations: twin, triplet, and higher-order multifetal pregnancies. Obstet. Gynecol. 2014; 123(5): 1118-32.

7. Adashi E.Y., Gleicher N. Is a blanket elective single embryo transfer policy defensible? Rambam Maimonides Med. J. 2017; 8(2): e0022. https://dx.doi.org/10.5041/RMMJ.10299.

8. Blickstein I., Keith L.G., eds. Multiple pregnancy. Epidemiology, gestation and perinatal outcome. Taylor & Fransis; 2005.

9. Stamenov G.S., Parvanov D.A., Chaushev T.A. Mixed double-embryo transfer: A promising approach for patients with repeated implantation failure. Clin. Exp. Reprod. Med 2017; 44(2): 105-10.

10. Калинина Е.А., Владимирова И.В., Сухих Г.Т. Монохориальная триамниотическая тройня в программе ВРТ: клиническое наблюдение. Акушерство и гинекология. 2016; 4: 151-3. [Kalinina E.A., Vladimirova I.V., Sukhikh G.T. Monochorial triamniotic triplet in ART program: clinical observation. Obstetrics and gynecology. 2016; 4: 151-3. (in Russian)].

11. Han E.J., Kim S.K., Lee J.R., Jee B.C., Suh C.S., Kim S.H. Multiple pregnancy after single or multiple embryo transfer performed according to Korean guidelines. Clin. Exp. Reprod. Med. 2015; 42(4): 169-74.

12. Malvasi A., Tinelli A., Di Renzo G.C., eds. Management and therapy of early pregnancy complications. Springer; 2016.

13. Долгушина Н.В., Ибрагимова Э.О., Романов А.Ю., Макарова Н.П., Довгань А.А., Сыркашева А.Г., Калинина Е.А. Роль проназного хетчинга в повышении эффективности программ вспомогательных репродуктивных технологий. Акушерство и гинекология. 2018; 3: 70-5. [Dolgushina N.V., Ibragimova E.O., Romanov A.Yu., Makarova NP, Dovgan A.A., Syrkasheva A.G., Kalinina E.A. The role of pronazy hetching in improving the efficiency of assisted reproductive technology programs. Obstetrics and gynecology. 2018; 3: 70-5. (in Russian)].

14. Савельева Г.М., Шалина Р.И., Панина О.Б., Астраханцева М.М., Спиридонов Д.С. Проблема преждевременных родов в современном акушерстве. Российский медицинский журнал. 2014; 20(5): 4-8. [Savelieva G.M., Shalina R.I., Panina OB, Astrakhantseva M.M., Spiridonov D.S. The problem of premature birth in modern obstetrics. Russian medical journal. 2014; 20 (5): 4-8. (in Russian)].

15. Hack K.E.A., Vereycken M.E.M.S., Torrance H.L., Koopman-Esseboom C., Derks J.B. Perinatal outcome of monochorionic and dichorionic twins after spontaneous and assisted conception: a retrospective cohort study. Acta Obstet. Gynecol. Scand. 2018; 97(6): 717-26.

16. Ezugwu E.C., Van der Burg S. Debating elective single embryo transfer after in vitro fertilization: a plea for a context-sensitive approach. Ann. Med. Health Sci. Res. 2015; 5(1): 1-7. https://dx.doi.org/10.4103/2141-9248.149761.

17. Practice Committee of American Society for Reproductive Medicine. Practice Committee of Society for Assisted Reproductive Technology. Criteria for number of embryos to transfer: A committee opinion. Fertil. Steril. 2013; 99(1): 44-6.

18. Приказ Министерства здравоохранения Российской Федерации №107н от 12 февраля 2013г. «О порядке использования вспомогательных репродуктивных технологий, противопоказаниях и ограничениях к их применению». [Order of the Ministry of Health of the Russian Federation No. 107n of February 12, 2013. «On the use of assisted reproductive technologies, contraindications and restrictions on their use». (in Russian)].

19. Lee A.M., Connell M.T., Csokmay J.M., Styer A.K. Elective single embryo transfer- the power of one. Contracept. Reprod. Med. 2016; 1: 11. https://dx.doi.org/10.1186/s40834-016-0023-4.

20. Templeton A. IVF treatment and single embryo transfer. Facts Views Vis. Obgyn. 2014; 6(1): 5-6.

21. Styer A.K., Luke B., Vitek W., Christianson M.S., Baker V.L., Christy A.Y., Polotsky A.J. Factors associated with the use of elective single embryo transfer and pregnancy outcomes in the United States, 2004–2012. Fertil. Steril. 2016; 106(1): 80-9. https://dx.doi.org/10.1016/j.fertnstert.2016.02.034.

22. Eftekhar M., Rahmani E., Pourmasumi S. Evaluation of clinical factors influencing pregnancy rate in frozen embryo transfer. Iran. J. Reprod. 2014; 12(7): 513-8.

23. Савельева Г.М., Касьянова Г.В., Дронова М.А., Карачунская Е.М. Вспомогательные репродуктивные технологии: перинатальные исходы и состояние детей. Проблемы репродукции. 2014; 20(6): 35-9. [Savelieva G.M., Kasyanova G.V., Dronova M.A., Karachunskaya E.M. Assisted reproductive technologies: perinatal outcomes and the state of children. Reproduction problems. 2014; 20 (6): 35-9. (in Russian)].

24. Practice Committee of Society for Assisted Reproductive Technology, Practice Committee of American Society for Reproductive Medicine. Elective single-embryo transfer. Fertil. Steril. 2012; 97(4): 835-42.

25. Ajduk A., Zernicka-Goetz M. Advances in embryo selection methods. F1000 Biol. Rep. 2012; 4: 11.

26. Stern H.J. Preimplantation genetic diagnosis: prenatal testing for embryos finally achieving its potential. J. Clin. Med. 2014; 3(1): 280-309.

27. Lu L., Lv B., Huang K., Xue Z., Zhu X., Fan G. Recent advances in preimplantation genetic diagnosis and screening. J. Assist. Reprod. Genet. 2016; 33(9): 1129-34.

28. Preconception care: Maximizing the gains for maternal and child health. Available at: http://www.who.int/maternal_child_adolescent/documents/preconception_care_policy_brief.pdf Accessed 01.10.2018.

29. Прегравидарная подготовка: клинический протокол. Радзинский В.Е. и др. авт.-разраб. М.: Редакция журнала StatusPraesens; 2016. 80с. [Pregravid preparation: clinical protocol. Radzinsky V.E. et al. author-developed. M .: Editorial staff of StatusPraesens magazine; 2016. 80p. (in Russian)].

30. Пустотина О.А. Прегравидарная подготовка. Медицинский совет. 2017; 13: 64-70. [Pustotina O.A. Pregravid preparation. Medical advice. 2017; 13: 64-70. (in Russian)].

31. Bialystok L., Poole N., Greaves L. Preconception care: call for national guidelines. Can. Fam. Physician. 2013; 59(10): 1037-9.

32. Савельева Г.М., Курцер М.А., Панина О.Б., Сичинава Л.Г., Алексеенкова М.В., Коноплянников А.Г., Латышкевич О.А. Прегравидарная подготовка в профилактике преждевременных родов. Вопросы гинекологии, акушерства и перинатологии. 2017; 16(6): 24-9. [Savelieva G.M., Kurtser M.A., Panina O.B., Sichinava L.G., Alekseenkova M.V., Konoplyannikov A.G., Latyshkevich O.A. Pregravid preparation in the prevention of preterm labor. Issues of gynecology, obstetrics and perinatology. 2017; 16 (6): 24-9. (in Russian)].

33. Наими З.М.С., Калинина Е.А., Донников А.Е., Алиева K.У., Дударова А.Х., Тухватуллина Я.А. Эффективность программ вспомогательных репродуктивных технологий при переносе эмбрионов в стимулированном цикле по сравнению с переносом криоконсервированных/размороженных эмбрионов. Акушерство и гинекология. 2016; 6: 11-7. [Naimi Z.M.S., Kalinina E.A., Donnikov A.E., Aliyev K.U., Dudarova A.Kh., Tukhvatullina Ya.A. The effectiveness of assisted reproductive technology programs in embryo transfer in the stimulated cycle compared to the transfer of cryopreserved / thawed embryos. Obstetrics and gynecology. 2016; 6: 11-7. (in Russian)].

Received 29.11.2018

Accepted 07.12.2018

About the Authors

Papysheva, Elena I., clinical graduate student of the Department of Obstetrics and Gynecology of Pediatric Faculty, Pirogov Russian National Research Medical University. 117997, Russia, Moscow, Ostrovityanova str. 1. Tel.: +79856446900.
E-mail: epapysheva@mail.ru
Karaganova, Elena Ya., PhD, associate professor of the Department of Obstetrics and Gynecology of Pediatric Faculty, Pirogov Russian National Research Medical University. 117997 Russia, Moscow, Ostrovityanova str. 1. Tel.: +79166849505.
E-mail: karaganova22@gmail.com
Breusenko, Larisa E., PhD, associate professor of the Department of Obstetrics and Gynecology of Pediatric Faculty, Pirogov Russian National Research Medical University. 117997 Russia, Moscow, Ostrovityanova str. 1. Tel.: +79859988708.
E-mail: 9988708@mail.ru

For citations: Papysheva E.I., Karaganova E.Yu., Breusenko L.E. The problem of multiple pregnancy in the infertility treatment with assisted reproductive techniques. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2019; (5): 137-43. (in Russian)
http://dx.doi.org/10.18565/aig.2019.5.137-143

Similar Articles

By continuing to use our site, you consent to the processing of cookies that ensure the proper functioning of the site.