Use of micronized progesterone in the prevention and therapy of miscarriage

DOI

https://dx.doi.org/10.18565/aig.2019.2.148-156

Ignatko I.V., Strizhakov A.N., Kuznetsov A.S., Churganova A.A., Lebedev V.A., Bogacheva N.A., Bogomazova I.M., Kardanov M.A.
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia, Moscow, Russia

The authors have carried out a systems analysis of the data available in the current literature on the features of different clinical situations and on the evaluation of the efficacy of micronized progesterone during pregravid preparation in pregnant women at high risk for reproductive losses and in those with recurrent miscarriage or threatened pregnancy termination. The current protocols using micronized progesterone have been investigated in women at high risk of preterm birth and in those with threatened early miscarriage, asymptomatic cervical shortening, or multiple pregnancy. Iprogine is one of the natural micronized progesterone preparations, which has been used to prevent early and late reproductive losses in European countries for over 20 years. The progesterone that is part of this drug is characterized by high bioavailability and proven efficacy irrespective of the route of administration (oral, intravaginal). Particular attention is paid to the neuroprotective effects of progesterone preparations in premature newborn infants; third-trimester therapy with micronized progesterone has been shown to play a role in preventing adverse neurological outcomes of preterm birth.

recurrent miscarriage

pregravid preparation

preterm labor

neuroprotection

micronized progesterone

Full text (in Russian)

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Received 15.02.2019

Accepted 22.02.2019

Ignatko, Irina V., MD, corresponding member of the Russian Academy of Sciences, professor of the Russian Academy of Sciences, professor of the Department of Obstetrics, Gynecology and Perinatology, Faculty of Medicine, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation
(Sechenov University). 119991, Russia, Moscow, Trubetskaya str. 8-2. Tel.: +74997823045. E-mail: iradocent@mail.ru
Strizhakov, Alexander N., MD, academician of the Russian Academy of Sciences, professor, head of the Department of Obstetrics, Gynecology and Perinatology,
Faculty of Medicine, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University).
119991, Russia, Moscow, Trubetskaya street, 8-2. Tel.: +74997823045. E-mail: kafedra-agp@mail.ru
Kuznetsov, Anton S., post-graduate student of the Department of Obstetrics, Gynecology and Perinatology, Faculty of Medicine, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University).
119991, Russia, Moscow, Trubetskaya street, 8-2. Tel.: +74997823045. E-mail: kafedra-agp@mail.ru
Churganova, Anastasia A., PhD, assistant professor of the Department of Obstetrics, Gynecology and Perinatology, Faculty of Medicine, I.M. Sechenov First Moscow
State Medical University of the Ministry of Health of the Russian Federation (Sechenov University).
119991, Russia, Moscow, Trubetskaya str. 8-2. Tel.: +74997823045. E-mail: kafedra-agp@mail.ru
Lebedev, Vladimir A., MD, professor of the Department of Obstetrics, Gynecology and Perinatology, Faculty of Medicine, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University). 119991, Russia, Moscow, Trubetskaya str. 8-2. Tel.: +74997823045. E-mail: iradocent@mail.ru
Bogacheva, Natalia A., PhD, assistant Professor of the Department of Obstetrics, Gynecology and Perinatology, Faculty of Medicine, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University).
119991, Russia, Moscow, Trubetskaya str. 8-2. Tel.: +74997823045. E-mail: kafedra-agp@mail.ru
Bogomazova, Irina M., PhD, docent of the Department of Obstetrics, Gynecology and Perinatology, Faculty of Medicine, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University). 119991, Russia, Moscow, Trubetskaya str. 8-2. Tel.: +74997823045. E-mail: kafedra-agp@mail.ru
Kardanova, Madina A., PhD, assistant Professor of the Department of Obstetrics, Gynecology and Perinatology, Faculty of Medicine, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University).
119991, Russia, Moscow, Trubetskaya str. 8-2. Tel.: +74997823045. E-mail: kafedra-agp@mail.ru

For citations: Ignatko I.V., Strizhakov A.N., Kuznetsov A.S., Churganova A.A., Lebedev V.A., Bogacheva N.A., Bogomazova I.M., Kardanova M.A. Use of micronized progesterone in the prevention and therapy of miscarriage. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2019; (2): 148-56. (in Russian)
http://dx.doi.org/10.18565/aig.2019.2.148-156

Use of micronized progesterone in the prevention and therapy of miscarriage

Ignatko I.V., Strizhakov A.N., Kuznetsov A.S., Churganova A.A., Lebedev V.A., Bogacheva N.A., Bogomazova I.M., Kardanov M.A.

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