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The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
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Obstetrics and Gynegology2024№3
The use of botulinum neuropeptide...

The use of botulinum neuropeptide in gynecology

DOI
https://dx.doi.org/10.18565/aig.2023.282

Sokolova A.V., Ushakova K.A., Apolikhina I.A.

Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, Moscow, Russia

Botulinum toxin is a high-molecular protein complex produced by bacteria of the Clostridium genus. It is one of the most powerful organic poisons. Nevertheless, botulinum toxin has become widely used in medical practice due to its unique properties. There are several serotypes of the neurotoxin: BT-A, BT-B, BT-C, BT-D, BT-E, BT-F, BT-G, B-X, and non-clostridial nature: BT-Wo, BT-En. The most common one is botulinum toxin type A which blocks the release of certain neurotransmitters at the neuromuscular junction and leads to a temporary decrease in muscle activity. Botulinum toxin type A has been used for more than 20 years for the symptomatic treatment of various conditions associated with excessive muscle activity. Moreover, botulinum toxin is known as an effective and fast-acting substance in the treatment of chronic pain due to its antinociceptive (analgesic) and anti-inflammatory properties. Recently, the researchers have become particularly interested in the use of botulinum toxin in gynecology, especially in the treatment of diseases such as pelvic floor muscle hyperactivity and vaginismus, vulvodynia and chronic pelvic pain, when first-line therapy is ineffective. Despite the fact that these diseases are not life-threatening, they significantly reduce the quality of patients’ lives. For clinicians who regularly deal with these clinical cases, botulinum toxin type A becomes a valuable medication in the treatment of difficult patients when traditional methods are ineffective.
Conclusion: Different mechanisms of botulinum toxin action as well as the latest research in the field of neurogynecology are considered in this article. The literature review includes publications confirming the effectiveness and safety of the use of this neuropeptide for the treatment of conditions associated with increased tone of the pelvic floor muscles. However, it is necessary to conduct further research for determining the optimal dosages, treatment regimens and evaluation of the long-term efficacy and safety of botulinum toxin in gynecology.

Authors’ contributions: Sokolova A.V. – review of publications on the issue of the article, writing the text, editing the text; Ushakova K.A. – review of publications on the issue of the article, writing the text; Apolikhina I.A. – editing the article.
Conflicts of interest: The authors declare no possible conflicts of interest.
Funding: The study was conducted without sponsorship.
For citation: Sokolova A.V., Ushakova K.A., Apolikhina I.A. The use of botulinum neuropeptide in gynecology.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2024; (3): 28-34 (in Russian)
https://dx.doi.org/10.18565/aig.2023.282

Keywords

botulinum therapy
botulinum toxin
neuropeptide
vaginismus
chronic pelvic pain
pelvic floor hypertonicity
botulinum therapy in gynecology
neurogynecology
Full text (in Russian)

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Received 07.12.2023

Accepted 07.03.2024

About the Authors

Anastasia V. Sokolova, MD, obstetrician-gynecologist, V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology,
Ministry of Health of Russia, 4, Oparina str., Moscow, 117997, Russia, +7(915)455-31-32, stasia0590@mail.ru
Kseniia A. Ushakova, student, Pirogov Russian National Research Medical University, Ministry of Health of Russia, 1, Ostrovityanova str., Moscow,
117997, Russia, +7(925)379-33-03, x.ushakova1468@bk.ru
Inna A. Apolikhina, Dr. Med. Sci., Professor, Head of the Department of Aesthetic Gynecology and Rehabilitation, V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia; Professor at the Department of Obstetrics, Gynecology, Perinatology, and Reproductology,
Institute of Professional Education, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, +7(495)735-10-55, apolikhina@inbox.ru,
https://orcid.org/0000-0002-4581-6295, 117997, Russia, Moscow, Ac. Oparina str., 4.

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