Preeclampsia: contemporary concepts of its pathogenesis

Boris D.A., Shmakov R.G.

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia
The review analyzes Russian and foreign literature sources on the pathogenesis of preeclampsia. The latter is considered to be an urgent and unsolved problem in modern obstetrics. The wide prevalence, the complexity of etiopathogenesis, the lack of accurate and highly informative methods for prediction and diagnosis, as well as the insufficient effectiveness of therapeutic and preventive measures are a cause of higher global maternal and perinatal morbidity and mortality rates of preeclampsia. Understanding the pathogenetic mechanisms implicated in the development and progression of preeclampsia is of fundamental importance and plays an important role in specifying the causes of this pregnancy complication, which should be treated.
Conclusion: Based on the analysis of the data available in the literature, the authors summarize the current aspects of the development and progression of preeclampsia.


pathogenesis of preeclampsia


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Received 07.08.2022

Accepted 22.11.2022

About the Authors

Daiana A. Boris, PhD, Researcher, V.I. Kulakov NMRC for OG&P, Ministry of Health of Russia, +7(915)081-89-97,,, 117997, Russia, Moscow, Ac. Oparina str., 4.
Roman G. Shmakov, Dr. Med. Sci, Professor of the Russian Academy of Sciences, Director of the Institute of Obstetrics, V.I. Kulakov NMRC for OG&P, Ministry of Health
of Russia; Head Specialist in Obstetrics of Ministry of Health of Russia, +7(495)438-72-00,,,
117997, Russia, Moscow, Ac. Oparina str., 4.

Authors’ contributions: Boris D.A., Shmakov R.G. – development of the design of the investigation, obtaining the data to be analyzed, review of publications on the topic of the article, writing the text of the manuscript.
Conflicts of interest: The authors declare that there are no possible conflicts of interest.
Funding: The investigation has been conducted within the framework of State Assignment 121032500100-3.
For citation: Boris D.A., Shmakov R.G. Preeclampsia: contemporary concepts of its pathogenesis.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2022; 12: 12-17 (in Russian)

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