Prevention of hemolytic disease of the fetus and newborn by anti-D-immunoprophylaxis
Objective. To analyze the data available in the current literature regarding the prevention of hemolytic disease of the fetus and newborn by anti-D immunoprophylaxis.Pavlova N.G.
Material and methods. The review included the data of foreign and Russian articles published in the past 10 years and found in PubMed on this topic.
Results. The review presents the epidemiology and pathogenesis of sensitization in Rh-negative pregnant women having an Rh-positive fetus, the need for immunoprophylaxis of hemolytic disease of the fetus and newborn, indications, regimens, and the required volumes of immunoprophylaxis in different obstetric situations, and the choice of an immunoglobulin.
Conclusion. Understanding the pathogenetic bases for the immunoprophylaxis of D-sensitization, as well as steady execution of clinical guidelines for the management of patients having pregnancy in rhesus-incompatibility marriage will assist in improving perinatal indicators and reproductive health in women.
Keywords
Rh-isoimmunization in pregnancy
anti-D immunoprophylaxis
hemolytic disease of the fetus
anti-D immunoglobulins
rhesonativ
References
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Received 16.06.2017
Accepted 23.06.2017
About the Authors
Pavlova Natalia Grigorievna, MD, Professor of the Department of Obstetrics, Gynecology and Reproduction, I.P. Pavlov First St. Petersburg State Medical University;Professor of the Department of Obstetrics, Gynecology and Reproduction of the St. Petersburg State University; Deputy Chief Physician for Perinatology
of Maternity Hospital No. 6 in St. Petersburg. 191014, Russia, St. Petersburg, Mayakovskogo str. 5. Tel.: +79219304493. E-mail: ngp05@yandex.ru
For citations: Pavlova N.G. Prevention of hemolytic disease of the fetus and
newborn by anti-D-immunoprophylaxis. Akusherstvo i Ginekologiya/
Obstetrics and Gynecology. 2017; (9): 138-43. (in Russian)
http://dx.doi.org/10.18565/aig.2017.9.138-43
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