Noninvasive techniques for the diagnosis and treatment of rhesus sensitization

DOI

https://dx.doi.org/10.18565/aig.2019.11.14-19

Zavyalova I.V., Fedorova T.A., Rogachevsky O.V., Gurbanova S.R., Pavlovich S.V.
Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow

The review analyzes data on the use of noninvasive techniques to treat rhesus sensitization in pregnancy. The high efficiency of efferent treatment methods, such as plasmapheresis and plasma exchange, in combination with intravenous immunoglobulin can decline the number of anti-Rh antibodies and, thereby, prevent the development of hemolytic disease of the fetus and newborn, as well as reduce the percentage of use and timing of invasive treatments, such as intrauterine fetal blood transfusion in women with high antibody titers and a family obstetric history. The efficiency of treatment results from the removal of Rh antibodies from the bloodstream during efferent treatment methods, and, the administration of intravenous immunoglobulins ensures the temporary prevention of Rh antibody production.

rhesus sensitization in pregnant women

therapeutic plasmapheresis

hemolytic disease of the fetus

plasma exchange

immunoglobulin therapy

Full text (in Russian)

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Received 20.06.2019

Accepted 21.06.2019

Inna V. Zavyalova, PhD., researcher of the Department of extracorporal methods of treatment and detoxification, FGBU «National Medical Research Center of Obstetrics, Gynecology and Perinatology named after Acad. V.I. Kulakov, Ministry of Health of Russia».
Address: Moscow 117997, Ac. Oparina str.4, Russia.
Tatiana A. Fedorova, MD. professor, Chief of transfusional department of FGBU «National Medical Research Center of Obstetrics, Gynecology and Perinatology named
after Acad. V.I. Kulakov, Ministry of Health of Russia».
Address: Moscow 117997, Ac. Oparina str.4, Russia.
Oleg V. Rogachevskiy, MD, head of the Department of extracorporal methods of treatment and detoxification, Professor Department of Anesthesiology and Resuscitation of FGBU «National Medical Research Center of Obstetrics, Gynecology and Perinatology named after Acad. V.I. Kulakov, Ministry of Health of Russia». Address: Moscow 117997, Ac. Oparina str.4, Russia.
Samira R. Gurbanova,Ph.D, researcher of the Department of extracorporal methods of treatment and detoxification, FGBU «National Medical Research Center of Obstetrics, Gynecology and Perinatology named after Acad. V.I. Kulakov, Ministry of Health of Russia».
Address: Moscow 117997, Ac. Oparina str.4, Russia.
Stanislav V. Pavlovich, Ph.D. Academic Secretary of FGBU «National Medical Research Center of Obstetrics, Gynecology and Perinatology named after Acad. V.I. Kulakov, Ministry of Health of Russia», e-mail: s_pavlovich@oparina.ru.
Address: Moscow 117997, Ac. Oparina str.4, Russia

For citation: Zavyalova I.V., Fedorova T.A., Rogachevsky O.V., Gurbanova S.R., Pavlovich S.V. Noninvasive techniques for the diagnosis and treatment of rhesus sensitization.
Akusherstvo i Ginekologiya/ Obstetrics and gynecology. 2019; 11: 14-19. (In Russian).
https://dx.doi.org/10.18565/aig.2019.11.14-19

Noninvasive techniques for the diagnosis and treatment of rhesus sensitization

Zavyalova I.V., Fedorova T.A., Rogachevsky O.V., Gurbanova S.R., Pavlovich S.V.

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