Fifty years of rhesus-immunization immunoprophylaxis: on guard of perinatal morbidity and infant mortality
The problem of prevention of hemolytic disease of the fetus and newborn among the indigenous population has been solved in economically developed countries due to the high organization of immunization. This issue is relevant to the present time in our country. The first clinical case of neonatal jaundice was described in 1609. The pathogenesis of the disease was determined three centuries later. American researchers obtained permission to use anti-rhesus gamma globulin in 1968. Since then it has been widely used abroad for both postpartum and antenatal prevention. Anti-rhesus immunoglobulin was introduced into clinical practice in our country thanks to the works of V.M. Sidelnikova. However, domestic drugs to date are not standardized in the micrograms. They can be used only after childbirth. We use foreign immunoglobulin during pregnancy. The cause of sensitization can be not only the lack of postnatal prevention, but also insufficient dose of the drug. To avoid this, we recommend implementing the Kleihauer-Betke method.Savelyeva G.M., Kurtser M.A., Sichinava L.G., Konoplyannikov A.G., Latyshkevich O.A., Songolova E.N.
Keywords
Keyword: Rh-sensitization
hemolytic disease
anti-D immunoglobulins
RhD-prophylaxis
preimplantation genetic diagnosis
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Received 30.11.2018
Accepted 07.12.2018
About the Authors
Savelyeva, Galina M., MD, professor, academician of the Russian Academy of Sciences, Department of Obstetrics and Gynecology, Russian National Research Medical University named after N.I. Pirogov. 117997, Russia, Moscow, Ostrovityanova str. 1. Tel.:+74957183472. E-mail: gms@cfp.ruKurtser, Mark A., MD, professor, academician of the Russian Academy of Sciences, head of Department of Obstetrics and Gynecology, Russian National Research Medical University named after N.I. Pirogov. 117997, Russia, Moscow, Ostrovityanova str. 1. Tel.:+74957183472. E-mail: agpf-gms@gmail.com
Sichinava, Lali G., MD, professor, Department of Obstetrics and Gynecology, Russian National Research Medical University named after N.I. Pirogov.
117997, Russia, Moscow, Ostrovityanova str. 1. Tel.:+74957183472. E-mail: agpf-gms@gmail.com
Konoplyannikov, Aleksandr G., MD, professor, Department of Obstetrics and Gynecology, Russian National Research Medical University named after N.I. Pirogov.
117997, Russia, Moscow, Ostrovityanova str. 1. Tel.:+74997230420. E-mail: npo.med@gmail.com
Latyshkevich, Oleg A., PhD, assistant, Department of Obstetrics and Gynecology, Russian National Research Medical University named after N.I. Pirogov.
117997, Russia, Moscow, Ostrovityanova str. 1 Tel.:+74957183472. E-mail: agpf-gms@gmail.com.
Chief doctor of Family planning and human reproduction center affiliated Moscow city Department of Health.
117209, Russia, Moscow, Sevastopolskiy pr. 24 A. Tel.:+4957182070. E-mail: cpsr@zdrav.mos.ru
Songolova, Ekaterina N., PhD, head of Division of Obstetrics and Gynecology, Scientific Research Institute of Healthcare Organization and medical Management.
115088, Russia, Moscow, Sharikopodshipnikovskaya str. 9. Tel.:+74956134119. E-mail: songolovaEN@zdrav.mos.ru
For citations: Savelyeva G.M., Kurtser M.A., Sichinava L.G., Konoplyannikov A.G., Latyshkevich O.A., Songolova E.N. Fifty years of rhesus-immunization immunoprophylaxis: on guard of perinatal morbidity and infant mortality (historical review). Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (12): 177-83. (in Russian)
http://dx.doi.org/10.18565/aig.2018.12.177-183
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