Preparation for the in vitro fertilization treatment of infertility in diminished ovarian reserve

DOI

https://dx.doi.org/10.18565/aig.2019.8.134-142

Vartanyan E.V., Tsaturova K.A., Devyatova E.A., Mikhailyukova A.S., Levin V.A., Sagamonova K.Yu., Gromenko D.S., Ovsyannikova T.V., Erlikhman N.M., Kolosova E.A., Safronova E.V., Fotina O.V., Krasnovskaya E.V, Pozharischenskaya T.G., Autleva S.R., Gzgzyan A.M., Nuriev I.R., Voropaeva E.E., Pestova T.I., Zdanovsky V.M., Kim N.A., Kotelnikov A.N., Safronov O.V., Nazarenko T.A., Ionova R.M.
1) OOO «Test-Tube Baby» Clinic for Assisted Reproductive Technologies, Moscow, Russia; 2) Department of Obstetrics and Gynecology, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia; 3) OOO «Center for Human Reproduction and IVF», Rostov-on-Don; 4) OOO «ANEKO», Ufa, Republic of Bashkortostan; 5) New Medical Technologies Clinic, OOO «Personalized Medicine Center», Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, Novosibirsk 6«Istochnik» (Source) IVF Clinic, Chelyabinsk; 7) ZAO «Malysh» (Baby) Medical Center, Tyumen; 8) OOO «IVF» Reproductive Health Clinic, Samara; 9) OOO «Filosofiya Zhizni» (Philosophy of Life), Perm; 10) OOO «Tonus Mama», Nizhny Novgorod; 11) OOO «Genesis Clinic», Simferopol, Republic of Crimea; 12) OOO «Kuban Medical Center», Krasnodar; 13) D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology, Saint Petersburg; 14) OOO «Nureevs Clinic», Clinical Medical Diagnostic Center, Kazan; 15) OOO «Infertility Treatment Center», Chelyabinsk; 16) ZAO «Family Medicine Center», Chelyabinsk; 17) OOO «Professor V.M. Zdanovsky Clinic», Moscow; 18) OOO «Perm Mother and Child», Perm; 19) OOO «Genome-Volga», Volgograd; 20) Department of Obstetrics and Gynecology, Institute of Advanced Professional Education, South Ural State Medical University, Ministry of Health of Russia, Chelyabinsk; 21) Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow; 22) Department of Obstetrics and Gynecology, Faculty of Advanced Professional Education, Stavropol State Medical University, Ministry of Health of Russia, Stavropol

Objective. To assess the quality of oocytes, embryos, and outcomes of in vitro fertilization (IVF) cycles in patients with diminished ovarian reserve (OR) who received inositol before infertility treatment. Subjects and methods. An observational comparative multicenter study pre-IVF TIDOR included 270 patients. Group 1 (n=158) took inositol 4000 mg + folic acid 400 μg (Inofert, Italfarmaco S.p.A., Italy); Group 2 (n=112) did not receive inositol before infertility treatment using IVF. The inclusion criteria were age <38 years; a history of ovarian surgery; AMH <1.0 pg/ml, transfer of ≤2 embryos (ET) in the ovarian stimulation (OS) cycle. Results. In Group 1 and Group 2, mature oocytes (n=5 (0–7) and 2 (0–5); p = 0.049) and good-quality embryos (42.2 and 30.1%; p = 0.049) were retrieved; there was a high rate of ET-induced pregnancy (38.1and 30.0%; p = 0.041). Conclusion. It is expedient to use inositol (Inofert, Italfarmaco S.p.A., Italy) in women younger than 38 years after ovarian surgery in order to enhance the efficiency of IVF.

ovarian reserve diminution

infertility

inositol

myo-inositol

in vitro fertilization

pregnancy

Full text (in Russian)

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Received 27.05.2019

Accepted 21.06.2019

Vartanyan Emma Vramovna, MD, professor of the Department of Obstetrics and Gynecology of Pirogov Russian National Research Medical University; President of the self-regulating society Association of VRT Clinics, obstetrician-gynecologist, reproductologist, director of «Test-Tube Babies» Clinic for Assisted Reproductive Technologies.
117997 Russia, Moscow, Ostrovitianov str., 1. 123182 Russia, Moscow, Schukinskaya str., 2.
Tsaturova Kristina Ashotovna, MD, chief physician of «Test-Tube Babies» Clinic for Assisted Reproductive Technologies, obstetrician-gynecologist, reproductologist.
123182 Russia, Moscow, Schukinskaya str., 2.
Devyatova Ekaterina Aleksandrovna, PhD, doctor of ultrasound diagnostics, obstetrician-gynecologist, «Test-Tube Babies» Clinic for Assisted Reproductive Technologies.
123182 Russia, Moscow, Schukinskaya str., 2.
Mikhaylyukova A.S., obstetrician-gynecologist, reproductologist, «Test-Tube Babies» Clinic for Assisted Reproductive Technologies.
123182 Russia, Moscow, Schukinskaya str., 2.
Levin V.A., endocrinologist, «Test-Tube Babies» Clinic for Assisted Reproductive Technologies. 123182 Russia, Moscow, Schukinskaya str., 2.
Sagamonova K.Y., MD, director of «Centre of Human Reproduction and IVF», professor of the Department of Obstetrics and Gynecology №4 of Rostov State Medical University, obstetrician-gynecologist, reproductologist. 344068 Russia, Rostov-on-Don, Bodraya str., 90А.
Gromenko D.S., MD, director of «АNEKO», urologist. 450029 Russia, Republic of Bashkortostan, Ufa, Puteyskaya str., 2.
Ovsyannikova T.V., MD, chief physician of Clinic NMT, IChBFM of SA RAS, OOO «CPM», obstetrician-gynecologist, reproductologist, doctor of ultrasound diagnostics.
630090 Russia, Novosibirsk, Pirogov str., 25/4.
Erlihman N.M., PhD, obstetrician-gynecologist, reproductologist, doctor of ultrasound diagnostics, Clinica IVF ISTOCHNIK. 454100 Russia, Chelyabinsk, Chicherina str., 36B.
Kolosova E.A., chief of the Medical Department of Medical Centre «Baby», obstetrician-gynecologist, reproductologist.
625002 Russia, Tumen, Sverdlov str., 35-1a.
Safronova Е.V., PhD, obstetrician-gynecologist, reproductologist, Clinic of Reproductive Health «IVF». 443030 Russia, Samara, K. Marx av., 6.
Fotina О.V., chief physician of Clinic «Philosophy of Life», obstetrician-gynecologist, reproductologist. 614107 Russia, Perm, Kim str., 64.
Krasnovskaya Е.V., chief physician of Clinic «Tonus Mother», obstetrician-gynecologist, reproductologist. 603000 Russia, Nizhny Novgorod, Vorovsky str., 22.
Pozharischenskaya Т.G., chief of the Department of Family Planning and Human Reproduction of «Genesis Clinic», obstetrician-gynecologist, reproductologist.
295026 Russia, Crimea Republic, Simferopol, Semashko str., 4.
Autleva S.R., PhD, obstetrician-gynecologist, reproductologist of «Kuban Medical Centre». 350072 Russia, Krasnodar, Moskovskaya str., 65.
Gzgzyan А.М., MD, professor of the Department of Obstetrics, Gynecology and Reproductology of Saint-Petersburg State University, chief of the Department of ART of Ott Research Institute of Russia, obstetrician-gynecologist, reproductologist. 199034 Russia, Saint-Petersburg, Mendeleev Line, 3.
Nuriev I.R., director of CMDC «Nurievs’ Clinic», urologist. 420110 Russia, Kazan, Kasimovs’ Brothers str., 40a.
Voropaeva Е.Е., MD, chief physician of «Centre of Management of Infertility», obstetrician-gynecologist, reproductologist, doctor of ultrasound diagnostics.
454048 Russia, Chelyabinsk, Yablochkina str., 3.
Pestova Т.I., PhD, chief physician of «Centre of Family Medicine», obstetrician-gynecologist, reproductologist. 454021 Russia, Chelyabinsk, Logovaya str., 13.
Zdanovsky V.М., MD, professor, director of LLC Clinic of Professor V. M. Zdanovsky, obstetrician-gynecologist, reproductive specialist.
115191 Russia, Moscow, Holodilny 2-2.
Кim N.А., PhD, obstetrician-gynecologist, reproductive specialist of «Mother and Child Perm», assistant lecture of the Department of Obstetrics and Gynecology of Faculty of Advanced Studies of Perm State Medical University named after academician E.A. Vagner. 614000 Russia, Perm, Ekaterininskaya str., 64.
Kotelnikov А.N., PhD, director of «Genom-Volga», anesthesiologist, reanimation specialist. 400078 Russia, Volgograd, Lenin av., 102A.
Safronov O.V., PhD., associate Professor, head of the Department of obstetrics and gynecology IPDO FSBEI HE South-Ural State Medical University, obstetrician-gynecologist.
454092, Russia, Chelyabinsk,Vorovskogo str., 64.
Nazarenko T.A., MD, professor, director of the institute reproductive medicine, National Medical Research Center of Obstetrics, Gynecology and Perinatology named after Academican V.I.Kulakov Ministry of Health of Russia, obstetrician-gynecologist, reproductologist. 117997 Russia Moscow, Ac. Oparina str., 4.
Ionova R.M., PhD., assistant of the Department of Obstetrics and Gynecology of FDPO GBOU VPO Stavropol State Medical University, obstetrician-gynecologist.
355017, Stavropol, ul. Mira, d. 310. For correspondence: the responsible author is Ekaterina Devyatova, e-mail: devyatova@baby-ivf.ru, tel .: 8 (495) 981-85-80.

For citations:Vartanyan E.V., Tsaturova K.A., Devyatova E.A., Mikhailyukova A.S., Levin V.A., Sagamonova K.Yu., Gromenko D.S., Ovsyannikova T.V., Erlikhman N.M., Kolosova E.A., Safronova E.V., Fotina O.V., Krasnovskaya E.V., Pozharischenskaya T.G., Autleva S.R., Gzgzyan A.M., Nuriev I.R., Voropaeva E.E., Pestova T.I., Zdanovsky V.M., Kim N.A., Kotelnikov A.N., Safronov O.V., Nazarenko T.A., Ionova R.M. Preparation for the in vitro fertilization treatment of infertility in diminished ovarian reserve.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2019; 8: 134-42 (in Russian)
https://dx.doi.org/10.18565/aig.2019.8.

Preparation for the in vitro fertilization treatment of infertility in diminished ovarian reserve

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