Placenta in pregnant women with chronic kidney disease

Barinova I.V., Nikolskaya I.G., Kotov Yu.B., Prokopenko E.I., Kondrikov N.I.

1) Moscow Regional Research Institute of Obstetrics and Gynecology, Moscow, Russia; 2) M.F. Vladimirsky Moscow Regional Research Clinical Institute, Moscow, Russia; 3) M.V. Keldysh Institute of Applied Mathematics, Russian Academy of Sciences, Moscow, Russia
Objective. To investigate placental structural features in chronic kidney disease (CKD) in pregnant women.
Material and methods. A total of 124 placentas were morphologically examined in pregnant women with different stages of CKD at 31-39 weeks’ gestation. The expression of Ki-67 and CD31 in the villous cytotrophoblast and capillary endothelium was investigated; the number and area of villous capillaries were counted. Clinical and morphological comparisons were carried out using the criteria for nonparametric statistics, as well as methods for statistical studies of non-numeric objects.
Results. With increasing severity of the underlying disease, at Stage 2 CKD, placental weight percentiles and neonatal weight and height indicators progressively decreased, there was a persistent tendency towards a sharp decrease in the number of villous capillaries, their narrowing to a few µm2.
Conclusion. The pathogenesis of placental morphological changes in CKD is due to preeclampsia.

Keywords

chronic kidney disease
placenta
immunohistochemical markers
preeclampsia
statistics of non-numerical objects

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Received 09.04.2019

Accepted 19.04.2019

About the Authors

Irina V. Barinova, MD, head of the pathological department of the GBUZ MO Moscow Regional Research Institute of Obstetrics and Gynecology.
Phone: +7(903)281-7334, e-mail: barinova.irina.vladimirovna@gmail.com, ORCID: http://orcid.org/0000-0003-0447-1734
Irina G Nikolskaya, Candidate of Medical Sciences, Scientific Secretary, GBUZ MO MONIIAG. Тел.:+7(926)119-6934, e-mail: nikolskaya.55@bk.ru
101000, Россия, Москва, ул. Покровка, д.22а.
Yuri B. Kotov, Leading Researcher, Institute of Applied Mathematics M.V. Keldysh RAS, Doctor of Physics and Mathematics, e-mail: kobylazabyla11@yandex.ru
61/2, Shchepkina Str., Moscow, 129110
Elena I. Prokopenko, MD, professor of the Department of Transplantology, Nephrology and Artificial Organs, Faculty of Advanced Medical Studies,
GBUZ MO MONIKI im. M.F. Vladimirsky. Tel +7 (903) 192 1168. ORCID ID: https://orcid.org/0000-0002-7686-9816 e-mail: renalnephron@gmail.com
129110 Russia, Moscow, ul. Schepkina 61/2.
Nikolay I. Kondrikov, MD, professor, pathologist at the pathology department of the GBUZ MO MONIIAG. Tel.: +7 (985)358-8473.
ORCID: http://orcid.org/0000-0003-0792-847X

For citation: Barinova I.V., Nikolskaya I.G., Kotov Yu.B., Prokopenko E.I., Kondrikov N.I. Placenta in pregnant women with chronic kidney disease.
Akusherstvo i Ginekologiya/ Obstetrics and gynecology. 2020; 1: 169-77. (In Russian).
https://dx.doi.org/10.18565/aig.2020.1.169-177.

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