Prospects for the combined use of trans-resveratrol and indole-3-carbinol in endometriosis

Yarmolinskaya M.I., Shalina M.A., Beganova A.K., Seyidova Ch.I.

1) D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint-Petersburg, Russia; 2) North-Western State Medical University named after I.I. Mechnikov, Ministry of Health of Russia, Saint-Petersburg, Russia
Endometriosis is considered to be a multifactorial disease, the prevalence of which does not tend to decrease, including in reproductive-aged women, with a delay in diagnosis ranging from 4 to 11 years. A number of disadvantages and side effects of the existing treatments, both surgical and medical, as well as the importance of long-term therapy for the disease justify the need to search for new approaches to drug treatment, both for combined use with known drugs, and as monotherapy. Based on the Russian and foreign literature sources of the electronic databases PubMed, CyberLeninka, and Google Scholar in the period from 2003 to 2021, as well as the results of the authors’ own studies, the review presents an update on the use of trans-resveratrol and indole-3-carbinol in external genital endometriosis and adenomyosis both in experimental models and in clinical practice. The pharmacological effects of compounds, (antioxidant, anti-inflammatory, antimicrobial, neuroprotective, anticarcinogenic, and others) determine the prospects for the combined use of trans-resveratrol and indole-3-carbinol in the treatment of various forms of genital endometriosis.
Conclusion: Further investigation is needed to adjust the most effective dosage regimens for the combination use of indole-3-carbinol 200 mg and trans-resveratrol 60 mg in patients with endometriosis and adenomyosis.


external genital endometriosis


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Received 23.03.2022

Accepted 28.03.2022

About the Authors

Maria I. Yarmolinskaya, Professor of Russian Academy of Sciences, Dr. Med. Sci., Professor, Head of the Department of Gynecology and Endocrinology, Head of the Center "Diagnostics and treatment of endometriosis", D.O.Ott Research Institute of Obstetrics, Gynecology and Reproductology; Professor at the Department of Obstetrics and Gynecology, North-Western State Medical University named after I.I. Mechnikov, Ministry of Health of Russia, +7(812)334-35-85,,, 199034, Russian Federation, Saint-Petersburg, Mendeleevskaya liniya, 3.
Maria A. Shalina, PhD, Senior Researcher at the Department Gynecology and Endocrinology, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, +7(812)334-35-85,,, 199034, Russian Federation, Saint-Petersburg, Mendeleevskaya liniya, 3.
Aleksandra K. Beganova, Junior Researcher, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, +7(911)938-56-33,,, 199034, Russian Federation, Saint-Petersburg, Mendeleevskaya liniya, 3.
Chimnaz I. kyzy Seyidova, Resident Physician, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, +7(960)886-56-38,,, 199034, Russian Federation, Saint-Petersburg, Mendeleevskaya liniya, 3.
Corresponding author: Aleksandra K. Beganova,

Authors' contributions: Yarmolinskaya M.I. – concept and design of the investigation, editing; Yarmolinskaya M.I., Shalina M.A., Beganova A.K., Ch.I. Seyidova Ch.I. – material collection and processing, writing the text.
Conflicts of interest: The authors declare that there are no manifest and potential conflicts of interest, which are related to the publication of this article.
Funding: The review has been prepared within basic research topic No. 1021062812154-3-3.2.2.
For citation: Yarmolinskaya M.I., Shalina M.A., Beganova A.K., Seyidova Ch.I. Prospects for the combined use of trans-resveratrol and indole-3-carbinol in endometriosis.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2022; 4: 14-24 (in Russian)

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