About
The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
ArchiveEthical StandardsSubscription
For authors
InstructionsInformed consent policyContract offerEASE GuidelinesICJME CriteriaWAME Recommendations on ChatGPT and Chatbots in Relation to Scholarly Publications
Reviewing
Procedure for reviewingReviewers 2023-2024
About
The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
ArchiveEthical StandardsSubscription
For authors
InstructionsInformed consent policyContract offerEASE GuidelinesICJME CriteriaWAME Recommendations on ChatGPT and Chatbots in Relation to Scholarly Publications
Reviewing
Procedure for reviewingReviewers 2023-2024
Logout
Obstetrics and Gynegology2021№4
Adenomyosis and infertility

Adenomyosis and infertility

DOI
https://dx.doi.org/10.18565/aig.2021.4.41-47

Aksenenko A.A., Gus A.I., Mishieva N.G.

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia
Endometriosis is one of the acute problems of modern gynecology; it is a gynecological disease characterized by the presence of heterotopias that are identical in structure and function with the endometrium outside the boundaries of the normal mucous membrane of the uterus. The incidence of endometriosis varies widely from 12% to 50% according to different authors. Despite a significant number of studies, the etiology and pathogenesis of various forms of endometriosis have not yet been established, which leads to different approaches to diagnosing and treating this disease. Adenomyosis (or internal endometriosis) occupies a special place among all types of endometriosis. The specific frequency of internal endometriosis of the corpus uteri (adenomyosis) in the structure of genital endometriosis varies from 9 to 70% according to different researchers, reaching 70-90% in some publications. Adenomyosis is used to denote the form of endometriosis, the morphological manifestation of which is the spread of the components of the glandular and stromal layer of the endometrium into the myometrium. Despite the fact that this term is far from new and is widely used in clinical practice; specialists do not cease discussions. The review discusses the etiology and pathogenesis, diagnosis, clinical features, and current approaches to the management of patients with infertility in adenomyosis.
Conclusion. The impact of adenomyosis and its stage on the outcomes of IVF programs, the need for and methods for preliminary treatment of patients before IVF are debatable.

Keywords

infertility
endometriosis
adenomyosis
in vitro fertilization
Full text (in Russian)

References

  1. Адамян Л.В., Кулаков В.И., Андреева Е.Н. Эндометриозы. Руководство для врачей. М.: Медицина; 2006. 416 с. [Adamyan L.V., Kulakov V.I., Andreeva E.N. Endometriosis: A Guide for Physicians. M.: Publishing house" Medicine", 2006. 416 р. (in Russian)].
  2. Дамиров М.М. Генитальный эндометриоз – болезнь активных и деловых женщин. М.: БИНОМ-Пресс; 2010. 192 с. [Damirov M.M. Genital endometriosis is a disease of active and business women. M.: Publishing house BINOM-Press, 2010. 192 р. (in Russian)].
  3. Oliveira R.D.E., Adami F., Mafra F.A., Bianco B., Vilarino F.L., Barbosa C.P. Causes of endometriosis and prevalent infertility in patients undergoing laparoscopy without achieving pregnancy Minerva Ginecol. 2016; 68(3): 250-8
  4. Клинические рекомендации. Эндометриоз. МКБ 10: N80. 2020г. [Clinical guidelines. Endometriosis, 2020. (in Russian)].
  5. Адамян Л.В., ред. Сочетанные доброкачественные опухоли и гиперпластические процессы матки (миома, аденомиоз, гиперплазия эндометрия): клинические рекомендации по ведению больных. М.; 2015. 26 с. [Adamyan L.V. Concomitant benign tumors and hyperplastic processes of the uterus (myoma, adenomyosis, endometrial hyperplasia): clinical guidelines for the management of patients. M., 2015. 26 p. (in Russian)].
  6. Pontis A., D'Alterio M.N., Pirarba S., de Angelis C., Tinelli R., Angioni S. Adenomyosis: a systematic review of medical treatment. Gynecol. Endocrinol. 2016; 32(9): 696-700. https://dx.doi.org/10.1080/09513590.2016.1197200.
  7. Haney A.F. The pathogenesis and aetiology of endometriosis. In: Thomas E., Rock J., eds. Modern approaches to endometriosis. London; 1991: 3-19.
  8. Адамян Л.В., Кулаков В.И. Эндометриозы. М.; 1998. 317 с. [Adamyan L.V., Kulakov V.I. Endometriosis. M., 1998. 317 p. (in Russian)].
  9. Naftalin J., Hoo W., Pateman K., Mavrelos D., Holland T., Jurkovic D. How common is adenomyosis? A prospective study of prevalence using transvaginal ultrasound in a gynaecology clinic. Hum. Reprod. 2012; 27(12): 3432-9. https://dx.doi.org/10.1093/humrep/des332.
  10. Di Donato N., Seracchioli R. How to evaluate adenomyosis in patients affected by endometriosis? Minim. Invasive Surg. 2014; 2014: 507230. https://dx.doi.org/10.1155/2014/507230.
  11. Gordts S., Koninckx P., Brosens I. Pathogenesis of deep endometriosis. Fertil. Steril. 2017; 108(6): 872-85. e1. https://dx.doi.org/10.1016/j.fertnstert.2017.08.036.
  12. Ищенко А.И., Кудрина Е.А. Эндометриоз: диагностика и лечение. М.: ГЭОТАР-Медиа; 2002. 104 с. [Ishchenko A.I., Kudrina E.A. Endometriosis: diagnosis and treatment. M.: GEOTAR-Media, 2002 . 104 p. (in Russian)].
  13. Brosens I., Pijnenborg R., Benagiano G. Defective myometrial spiral artery remodeling as a cause of major obstetrical syndromes in endometriosis and adenomyosis. Placenta. 2013; 34(2): 100-5. https://dx.doi.org/10.1016/j.placenta.2012.11.017.
  14. Coccia M.E., Rizzello F. Ultrasonographic staging: a new staging system for deep endometriosis. Ann. N. Y. Acad. Sci. 2011; 1221: 61-9. https://dx.doi.org/10.1111/j.1749-6632.2011.05951.x.
  15. Haas D., Wurm P., Shamiyeh A., Shebl O., Chvatal R., Oppelt P. Efficacy of the revised Enzian classification: a retrospective analysis. Does the revised Enzian classification solve the problem of duplicate classification in rASRM and Enzian? Arch. Gynecol. Obstet. 2013; 287(5): 941-5. https://dx.doi.org/10.1007/s00404-012-2647-1.
  16. Tamaresis J.S., Irwin J.C., Goldfien G.A., Rabban J.T., Burney R.O., Nezhat C., DePaolo L.V., Giudice L.C. Molecular classification of endometriosis and disease stage using high-dimensional genomic data. Endocrinology. 2014; 155(13): 4986-99. https://dx.doi.org/10.1210/en.2014-1490.
  17. Адамян Л.В., Андреева Е.Н. Генитальный эндометриоз: этиопатогенез, клиника, диагностика, лечение: Методическое пособие для врачей. М.; 2001. [Adamyan, L.V. Genital endometriosis: etiopathogenesis, clinical picture, diagnosis, treatment: Methodological guide for doctors / L.V. Adamyan, E.N. Andreeva. M., 2001. (in Russian)].
  18. Moore J., Kennedy S., Prentice A. Modern combined oral contraceptives for pain associated with endometriosis. Cochrane Database Syst. Rev. 2000; (2): CD001019.
  19. Atabekoğlu C.S., Şükür Y.E., Kalafat E., Özmen B., Berker B., Aytaç R., Sönmezer M. The association between adenomyosis and recurrent miscarriage. Eur. J. Obstet. Gynecol. Reprod. Biol. 2020; 250: 107-11. https://dx.doi.org/10.1016/j.ejogrb.2020.05.006.
  20. Buggio L., Monti E., Gattei U., Dridi D., Vercellini P. Adenomyosis: fertility and obstetric outcome. A comprehensive literature review. Minerva Ginecol. 2018; 70(3): 295-302. https://dx.doi.org/10.23736/S0026-4784.17.04163-6.
  21. Salamansen L.A., Hannan N.J., Dimitriadis E. Cytokines and chemokines during human embryo implantation: roles in implantation and early placentation. Semin. Reprod. Med. 2007; 25(6): 437-44. https://dx.doi.org/10.1055/s-2007-991041.
  22. Yen C.F., Liao S.K., Huang S.J., Tabak S., Arcuri F., Lee C.L. et al. Decreased endometrial expression of leukemia inhibitory factor receptor disrupts the STAT3 signaling in adenomyosis during the implantation window. Reprod. Sci. 2017; 24(8): 1176-86. https://dx.doi.org/10.1177/1933719116681515.
  23. Prasnikar E., Kunej T., Knez J., Repnik K., Potocnik U., Kovacic B. Determining the molecular background of endometrial receptivity in adenomyosis. Biomolecules. 2020; 10(9): 1311. https://dx.doi.org/10.3390/biom10091311.
  24. Mehasseb M.K., Bell S.C., Pringle J.H., Habiba M.A. Uterine adenomyosis is associated with ultrastructural features of altered contractility in the inner myometrium. Fertil. Steril. 2010; 93(7): 2130-6. https://dx.doi.org/10.1016/j.fertnstert.2009.01.097.
  25. Brosens J., Verhoeven H., Campo R., Gianaroli L, Gordts S., Hazekamp J. et al. High endometrial aromatase P450 mRNA expression is associated with poor IVF outcome. Hum. Reprod. 2004; 19(2): 352-6. https://dx.doi.org/10.1093/humrep/deh075.
  26. Mahajan N., Kaur S., Alonso M.R. Window of implantation is significantly displaced in patients with adenomyosis with previous implantation failure as determined by endometrial receptivity assay. Hum. Reprod. Sci. 2018; 11(4): 353-8. https://dx.doi.org/10.4103/jhrs.JHRS_52_18.
  27. Yang J.H., Chen M.J., Chen H.F., Lee T.H., Ho H.N., Yang Y.S. Decreased expression of killer cell inhibitory receptors on natural killer cells in eutopic endometrium in women with adenomyosis. Hum. Reprod. 2004; 19(9): 1974-8. https://dx.doi.org/10.1093/humrep/deh372.
  28. Савельева Г.М., Сухих Г.Т., Серов В.Н., Радзинский В.Е., Манухин И.Б. Гинекология. Национальное руководство. 2-е изд. М.: ГЭОТАР-Медиа; 2020. 1006с. [Savelyeva G.M., Sukhikh G.T., Serov V.N., Radzinsky V.E., Manukhin I.B. Gynecology: national guide. 2nd ed., reprint. and add. Moscow: GEOTAR-Media, 2020. 1006 p. (in Russian)].
  29. Iacovides S., Avidon I., Baker F.C. What we know about primary dysmenorrhea today: a critical review. Hum. Reprod. Update. 2015; 21(6): 762-78. https://dx.doi.org/10.1093/humupd/dmv039.
  30. Адамян Л.В., Андреева Е.Н. Клинико-генетические аспекты аденомиоза. Акушерство и гинекология. 1999; 3: 38-43. [Adamyan L.V., Andreeva E.N. Clinical and genetic aspects of adenomyosis. Obstetrics and Gynecology. 1999; 3: 38-43. (in Russian)].
  31. Adamyan L.V. Strategies of management of genital endometriosis. In: The 18th congress on controversies in obstetrics, gynecology and infertility. Vienna; 2013.
  32. Адамян Л.В., Сонова М.М. Лечение эндометриоза: поиск продолжается. Новая аптека. 2009; 3: 38-43. [Adamyan L.V., Sonova M.M. Treatment of endometriosis: the search continues. New pharmacy. 2009; 3: 38-43. (in Russian)].
  33. Jacobson T.Z., Duffy J.M., Barlow D.H., Farquhar C., Koninckx P.R., Olive D. Laparoscopic surgery for subfertility associated with endometriosis. Cochrane Database Syst. Rev. 2014; (8): CD001398. https://dx.doi.org/10.1002/14651858.CD001398.pub3.
  34. Сметник В.П., Тумилович Л.Г. Неоперативная гинекология. Руководство для врачей. 3-е изд. М.: МИА; 2006. 629 с. [Smetnik V.P., Tumilovich L.G. Non-operative gynecology. M., 2006. 629 p. (in Russian)].
  35. Демидов В.Н., Гус А.И., Адамян Л.В., Хачатрян А.К. Эхография органов малого таза у женщин. Вып.1. Эндометриоз. Практическое пособие. М.: ИИФ «Скрипто»; 1997. 60 с. [Demidov V.N., Gus A.I., Adamyan L.V., Khachatryan A.K. Echography of the pelvic organs in women. Endometriosis: A Practical Guide. M.; "Scripto", 1997. 60 p. (in Russian)].
  36. Савельева Г.М., Бреусенко В.Г., Каппушева Л.М. Гистероскопия. М.: ГЭОТАР-Медиа; 2001. 176с. [Savelyeva G.M., Breusenko V.G., Kappusheva L.M. Hysteroscopy. M.: GEOTAR-Media, 2001. 176 p. (in Russian).
  37. Гаврилова Т.Ю., Арсланян К.Н. и др. Узловая форма аденомиоза: органосберегающие операции и реабилитация больных репродуктивного возраста. В кн.: Кулаков В.И., Адамян Л.В., ред. Современные технологии в диагностике и лечении гинекологических заболеваний. М.: Пантори; 2005: 158-60. [Gavrilova T.Yu., Arslanyan K.N. et al. Nodal form of adenomyosis: organ-saving operations and rehabilitation of patients of reproductive age. Modern technologies in the diagnosis and treatment of gynecological diseases. Pantori, 2005; 158-160. (in Russian)].
  38. Hughes E., Fedorkow D., Collins J., Vandekerckhove P. Ovulation suppression for endometriosis. Cochrane Database Syst. Rev. 2007; (3): CD000155. https://dx.doi.org/10.1002/14651858.CD000155.pub2.
  39. Batt R., Yeh J. Mullerianosis: for developmental (embryonic) Mullerian diseases. Reprod. Sci. 2013; 20(9): 1030-7. https://dx.doi.org/10.1177/1933719112472736.
  40. Mavrelos D., Holland T.K., O’Donovan O., Khalil M., Ploumpidis G., Jurkovic D., Khalaf Y. The impact of adenomyosis on the outcome of IVF-embryo transfer. Reprod. Biomed. Online. 2017; 35(5): 549-54. https://dx.doi.org/10.1016/j.rbmo.2017.06.026.
  41. Краснопольская К.В., Назаренко Т.А., Попов А.А., Федоров А.А. ЭКО в современных алгоритмах лечения бесплодия при аденомиозе. М.: Медпресс-информ; 2019. 72 с. [Krasnopolskaya K.V., Nazarenko T.A., Popov A.A., Fedorov A.A. IVF in modern algorithms for the treatment of infertility in adenomyosis. M.: "Medpress-inform", 2019. 72 p. (in Russian)].
  42. Maheshwari A., Gurunath S., Fatima F., Bhattacharya S. Adenomyosis and subfertility: a systematic review of prevalence, diagnosis, treatment and fertility outcomes. Hum. Reprod. Update. 2012; 18(4): 374-92. https://dx.doi.org/10.1093/humupd/dms006.
  43. Benaglia L., Candotti G., Papaleo E., Pagliardini L., Leonardi M., Reschini M. et al. Pregnancy outcome in women with endometriosis achieving pregnancy with IVF. Hum. Reprod. 2016; 31(12): 2730-6. https://dx.doi.org/10.1093/humrep/dew210.
  44. Younes G., Tulandi T. Effects of adenomyosis on in vitro fertilization treatment outcomes: a meta-analysis. Fertil. Steril. 2017; 108(3): 483-90. e3. https://dx.doi.org/10.1016/j.fertnstert.2017.06.025.
  45. Hou X., Xing J., Shan H., Mei J., Sun Y., Yan G. et al. The effect of adenomyosis on IVF after long or ultra-long GnRH agonist treatment. Reprod. Biomed. Online. 2020; 41(5): 845-53. https://dx.doi.org/10.1016/j.rbmo.2020.07.027.
  46. Sharma S., Bathwal S., Agarwal N., Chattopadhyay R., Saha I., Chakravarty B. Does presence of adenomyosis affect reproductive outcome in IVF cycles? A retrospective analysis of 973 patients. Reprod. Biomed. Online. 2019; 38(1): 13-21. https://dx.doi.org/10.1016/j.rbmo.2018.09.014.
  47. Sallam H.M., Garcia-Velasco J.A., Dias S., Arici A. Long-term pituitary down-regulation before in vitro fertilization for women with endometriosis. Cochrane Database Syst. Rev. 2006; (1): CD004635.
  48. Lin J., Sun C., Zheng H. Gonadotropin-releasing hormone agonists and laparoscopy in the treatment of adenomyosis with infertility. Chin. Med. J. (Engl). 2000; 113(5): 442-5.
  49. Liang Z., Yin M., Ma M., Wang Y., Kuang Y. Effect of pretreatment with a levonorgestrel-releasing intrauterine system on IVF and vitrified-warmed embryo transfer outcomes in women with adenomyosis; Reprod. Biomed. Online. 2019; 39(1): 111-8. https://dx.doi.org/10.1016/j.rbmo.2019.03.101.
  50. De Ziegler D., Gayet V., Aubriot F.X., Fauque P. Use oral contraceptives in women with endometriosis bebore assisted rebroduction treatment improves outcomes. Fertil. Steril. 2010; 94(7): 2796-9. https://dx.doi.org/10.1016/j.fertnstert.2010.05.056.

Received 28.01.2021

Accepted 16.02.2021

About the Authors

Artem A. Aksenenko, gynecologist of the 1st Gynecology Department, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. E-mail: a_axenenko@oparina4.ru. 117997, Russia, Moscow, Ac. Oparina str., 4.
Alexander I. Gus, MD, Doctor of Medicine, Professor, the Head of Ultrasound and Functional Diagnostics Department, Radiology Division, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. E-mail: a_gus@oparina4.ru. 117997, Russia, Moscow, Oparina str., 4.
Nona G. Mishieva, PhD, senior researcher of 1st Gynecology Department, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. E-mail: nondoc555@mail.ru. 117997, Russia, Moscow, Ac. Oparina str., 4.

For citation: Aksenenko A.A., Gus A.I., Mishieva N.G. Adenomyosis and infertility.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2021; 4: 41-47 (in Russian)
https://dx.doi.org/10.18565/aig.2021.4.41-47

Similar Articles

№9 / 2024
Chekeneva N.A., Dumanovskaya M.R., Chuprynin V.D., Asaturova A.V., Buralkina N.A.
Comprehensive approach to the management of patients with endometriosis‑associated infertility using the fertility index
№8 / 2024
Dubinskaya E.D., Kolesnikova S.N., Alyoshkina E.V., Gasparov A.S.
Clinical risk factors for infertility in reproductive-age patients with intramural uterine fibroids
№7 / 2024
Igitova M.B., Kazanina A.B., Cherkasova T.M., Yavorskaya S.D., Dmitrienko K.V., Dolgova N.S.
Pregnancy after in vitro fertilization: obstetric and perinatal risks
№8 / 2024
Kraevaya Е.Е., Makarova N.P., Kalinina E.A., Nazarenko T.A.
The effectiveness of programs of embryo cryo-transfer into the uterine cavity in women with overweight and obesity
№9 / 2024
Pogosyan M.T., Nazarenko T.A., Krylova E.I., Kovalskaya V.A., Sannikova E.S.
Genetic factors of early embryo developmental arrest in in vitro fertilization programs
By continuing to use our site, you consent to the processing of cookies that ensure the proper functioning of the site.