Prospects of treating infertility in women over 40 using assisted reproductive technology with autologous oocytes

Khachatryan L.V., Makarova N.P., Kalinin A.P., Smolnikova V.Yu.

1) I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), Moscow, Russia; 2) Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, Moscow, Russia; 3) N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia
Today, childbearing in women of late reproductive age is not only a pressing clinical problem but also a social one. In couples in this age group, the pathogenesis of infertility is extremely complex, representing a combination of several factors that often require tailored treatment for individual patients.
This review presents data on the role of genetic factors and oxidative stress signaling pathways in the pathogenetic mechanisms underlying ovarian aging. The authors summarized various controlled ovarian stimulation protocols and approaches for the optimization of assisted reproductive technology in patients of late reproductive age. This article provides information about experimental studies that will expand our understanding of the prospects for treating infertility in patients of this age category.
Conclusion: The study of pathogenetic mechanisms of ovarian aging is one of the key directions for the optimization of infertility treatment in women of late reproductive age using ART with autologous oocytes and is of scientific interest for the future development of innovative therapeutic approaches for this cohort of patients.

Authors' contributions: Khachatryan L.V., Makarova N.P., Kalinin A.P., Smolnikova V.Yu. – concept of the article, search, review and analysis of relevant literature, manuscript drafting.
Conflicts of interest: The authors have no conflicts of interest to declare.
Funding: There was no funding for this study.
For citation: Khachatryan L.V., Makarova N.P., Kalinin A.P., Smolnikova V.Yu. Prospects of treating infertility in women over 40 using assisted reproductive technology with autologous oocytes. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2023; (4): 12-19 (in Russian)


assisted reproductive technology (ART)
optimization of ART programs
late reproductive age
oxidative stress
signaling pathways
ovarian aging


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Received 07.02.2023

Accepted 29.03.2023

About the Authors

Leah V. Khachatryan, postgraduate student of the Department of Obstetrics, Gynecology, Perinatology and Reproductology, Faculty of Postgraduate Professional Training of Physicians, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), +7(963)977-88-94,,, 119991, Russia, Moscow, Trubetskaya str., 8-2.
Natalya P. Makarova, PhD, Leading Researcher at the Department of Assistive Technologies in Infertility Treatment, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia,,, 117997, Russia, Moscow, Ac. Oparin str., 4.
Andrey P. Kalinin, student of the Faculty of Medicine, Pirogov Russian National Research Medical University, Ministry of Health of Russia, +7(985)157-78-31,, 117997, Russia, Moscow, Ostrovitianov str., 1.
Veronika Yu. Smolnikova, Dr. Med. Sci., Leading Researcher, Department of Assistive Technologies in Infertility Treatment, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia,, 117997, Russia, Moscow, Ac. Oparin str., 4.

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