Long-term consequences of the effect of alcohol on the fetus

Marianian A.Yu., Anisimova A.O., Kalkova A.N., Rashidova M.A., Rychkova L.V., Muradyan A.E.

Scientific Center of Family Health Problems and Human Reproduction, Irkutsk, Russia
High alcohol consumption is a social problem in our country and the world. The paper analyzes Russian and foreign literary sources for studying fetal alcohol syndrome (FAS) and fetal alcohol spectrum disorders (FASDs). By now, there have been a certain amount of studies on female alcohol use during pregnancy. FAS is observed for 1000 live newborns. There is no standard accounting system for the diagnosis of FAS/FASDs in any country of the world. A historical reference is given regarding the nature of alcohol effect on the fetus; however, the problem of the effects of alcohol metabolites at the biochemical and molecular levels requires further investigation. The babies who were born with the signs of FAS are noted to have phenotypic changes in the cerebral cranium and viscerocranium, morphological changes in brain tissue, mental disorders, and behavioral, neurological disorders. To prevent the occurrence of FAS/FASDs in children, it is necessary to enhance the role of medical workers in educating young people about the risk factors of these diseases.
Conclusion: the dissemination of modern information and the transfer of knowledge to pregnant women and reproductive-aged women by physicians, psychologists, social pedagog-ists, and social workers about the irreparable harm of their alcohol use done to the child are extremely important to prevent FAS and FASDs.
It is necessary to fix the attention of the society on the problem of FAS, to popularize a healthy lifestyle, to foster the alcohol use culture, as the ubiquitous availability of alcoholic beverages and the lack of self-discipline lead to harmful consequences.

Authors' contributions: Marianian A.Yu., Rychkova L.V. – the concept and design of the investigation, editing and approving the publication; Anismova A.O., Rashidova M.A., Kalkova A.N., Muradyan A.E. – material collection and processing, literature search for Russian and international studies in the Russian and international databases; Anisimova A.O., Kalkova A.N., Muradyan A.E. – analyzing the data of the published studies, writing the text.
Conflicts of interest: The authors declare that there are no conflicts of interest.
Funding: The authors declare that there is no external financing to conduct the investigation and to publish the article.
For citation: Marianian A.Yu., Anisimova A.O., Kalkova A.N., Rashidova M.A., Rychkova L.V., Muradyan A.E. Long-term consequences of the effect of alcohol on the fetus.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2023; (6): 16-22 (in Russian)


fetal alcoholic syndrome
fetal alcohol spectrum disorders


  1. Каткова И.П., Рыбальченко С.И. Бремя алкогольной смертности в России и ряде европейских стран. Социально-экономическое развитие государств Евразии и других зарубежных стран. Проблемы современной экономики. 2018; 3: 206-12. [Katkova I.P., Rybalchenko S.I. The burden of alcohol mortality in Russia and a number of European countries. Socio-economic development of the states of Eurasia and other foreign countries. Problems of Moderin Economics. 2018; (3): 206-12. (in Russian)].
  2. World Health Organization. Global status report on alcohol and health. World Health Organization; 2018. Available at: https://www.who.int/publications/i/item/9789241565639 13.10.2022.
  3. Popova S., Lange S., Probst C., Gmel G., Rehm J. Estimation of national, regional, and global prevalence of alcohol use during pregnancy and fetal alcohol syndrome: a systematic review and meta-analysis. Lancet Glob. Health. 2017; 5(3): 290-9. https://dx.doi.org/1016/S2214-109X(17)30021-9.
  4. Popova S., Lange S., Temple V., Poznyak V., Chudley A.E., Burd L. et al. Profile of mothers of children with fetal alcohol spectrum disorder: a population-based study in Canada. Int. J. Environ. Res. Public Health. 2020; 17(21): 7986.https://dx.doi.org/10.3390/ijerph17217986.
  5. Марянян А.Ю., Калькова А.Н. Современный взгляд на тератогенное влияние алкоголя при беременности. Возможные меры профилактики. Акушерство, гинекология и репродукция. 2022; 16(1): 48-57. [Marianian A.Yu., Kalkova A.N. A modern view on the teratogenic effect of alcohol during pregnancy. Possible preventive measures. Obstetrics, Gynecology and Reproduction. 2022; 16(1): 48-57. (in Russian)].https://dx.doi.org/10.17749/2313-7347/ob.gyn.rep.2021.254.
  6. Addila A.E., Bisetegn T.A., Gete Y.K., Mengistu M.Y., Beyene G.M. Alcohol consumption and its associated factors among pregnant women in Sub-Saharan Africa: a systematic review and meta-analysis' as given in the submission system. Subst. Abuse Treat. Prev. Policy. 2020; 15(1): 29. https://dx.doi.org/10.1186/s13011-020-00269-3.
  7. Hanson J.D., Oziel K., Sarche M., MacLehose R.F., Rosenman R., Buchwald D. A culturally tailored intervention to reduce risk of alcohol-exposed pregnancies in American Indian communities: Rationale, design, and methods. Contemp. Clin. Trials. 2021; 104: 106351. https://dx.doi.org/10.1016/j.cct.2021.106351.
  8. Treskina N.A., Postoev V.A., Usynina A.A., Grjibovski A.M., Odland J.Ø. Secular trends of socio-demographic and lifestyle characteristics among delivering women in Arctic Russia, 1973-2017. Int. Circumpolar. Health. 2023; 82: 2161131. https://dx.doi.org/1080/22423982.2022.2161131.
  9. Lemoine P., Harousseau H., Borteyru J.P., Menuet J.C. Les enfants de parents alcooliques: anomalies observees a propos de 127 cas. Ouest Medicale. 1968; 21(2): 476-82.
  10. Jones K.L., Smith D.W. Recognition of the fetal alcohol syndrome in early infancy. Lancet. 1973; 2: 999-1001.
  11. Calhoun F., Warren K. Fetal alcohol syndrome: historical perspectives. Neurosci. Biobehav. Rev. 2007; 31(2): 168-71. https://doi.org/10.1016/j.neubiorev.2006.06.023.
  12. Ikehara S., Kimura T., Kakigano A., Sato T., Iso H. Association between maternal alcoholconsumption during pregnancy and risk of preterm delivery: the Japan Environment and Children’s Study. BJOG. 2019; 126(12): 1448-55.https://dx.doi.org/10.1111/1471-0528.15899.
  13. Brown J.M., Bland R., Jonsson E., Greenshaw A.J. The standardization of diagnostic criteria for fetal alcohol spectrum disorder (FASD): implications for research, clinical practice and population health. Can. J. Psychiatry. 2019; 64(3): 169-76. https://dx.doi.org/10.1177/0706743718777398.
  14. Бюллетень Всемирной организации здравоохранения. 2011; 89(6): 398-9. [Bulletin of World Health Organization. 2011; 89(6): 398-9. (in Russian)]. https://dx.doi.org/10.2471/BLT.11.020611.
  15. Малахова Ж.Л., Шилко В.И., Бубнов А.А. Фетальный алкогольный синдром у детей раннего возраста. М.; 2012. 164с. [Malakhova Zh.L., Shilko V.I., Bubnov A.A. Fetal alcohol syndrome in children of early age. Moscow; 2012. 164p. (in Russian)].
  16. Вalashova T.N.; Prevent FAS Research Group. Developing education-al materials for prevention of FASD in Russia. CDC Grantees. Meeting 14-15 August, 2008. Atlanta; 2008.
  17. Murawski N.J., Moore E.M., Thomas J.D., Riley E.P. Advances in diagnosis and treatment of fetal alcohol spectrum disorders: from animal models to human studies. Alcohol Res. 2015; 37(1): 97-108.
  18. Astley S.J., Clarren S.K. Diagnostic guide to FAS and related condi-tions: the 4-digit diagnostic code. 1st ed. Monograph. Seattle: Univer-sity of Washington Publication Services; 1997. 138p.
  19. Bertrand J. National task force on FAS/FAE fetal alcohol syndrome: guidelines for referral and diagnosis. Monograph. Atlanta GA: Centers for Disease Control and Prevention; 2004. 179p.
  20. Hoyme H.E., May P.A., Kalberg W.O.., Kodituwakku P., Gossage J.P., Trujillo P.M. et al. A practical clinical approach to diagnosis of fetal alcohol spectrum disorders: clarification of the 1996 institute of medi-cine criteria. Pediatrics. 2005; 115(1): 39-47. https://dx.doi.org/10.1542/peds.2004-0259.
  21. Chudley A.E., Conry J., Cook J.L., Loock C., Rosales T., LeBlanc N. Fetal alcohol spectrum disorder: Canadian guidelines for diagnosis. CMAJ. 2005; 172(5,Suppl.): S1-S21. https://dx.doi.org/10.1503/cmaj.1040302.
  22. Hur Y.M., Choi .J, Park S., Oh S.S., Kim Y.J. Prenatal maternal alcohol exposure: diagnosis and prevention of fetal alcohol syndrome. Obstet. Gynecol. Sci. 2022; 65(5): 385-94. https://dx.doi.org/10.5468/ogs.22123.
  23. Colom J., Segura-García L., Bastons-Compta A., Astals M., Andreu-Fernandez V., Barcons N. et al. Prevalence of fetal alcohol spectrum disorders (FASD) among children adopted from eastern european countries: Russia and Ukraine. Int. J. Environ. Res. Public Health. 2021; 18(4): 1388. https://dx.doi.org/10.3390/ijerph18041388.
  24. May P.A., Fiorentino D., Phillip Gossage J., Kalberg W.O., Eugene Hoyme H., Robinson L.K. et al. Epidemiology of FASD in a province in Italy: Prevalence and characteristics of children in a random sample of schools. Alcohol. Clin. Exp. Res. 2006; 30(9): 1562-75. https://dx.doi.org/10.1111/j.1530-0277.2006.00188.x.
  25. May P.A., de Vries M.M., Marais A.S., Kalberg W.O., Buckley D., Hasken J.M. et al. The prevalence of fetal alcohol spectrum disorders in rural communities in South Africa: A third regional sample of child characteristics and maternal risk factors. Alcohol. Clin. Exp. Res. 2022; 46(10): 1819-36.https://dx.doi.org/10.1111/acer.14922.
  26. Murakami K., Obara T., Ishikuro M., Ueno F. Noda A., Kuriyam Sh. et al. Associations of education and work statuswith alcohol use and cessation amongpregnant women in Japan: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. BMC Public Health. 2021; 21(1): 1400. https://dx.doi.org/10.1186/s12889-021-11461-w.
  27. Robert M., Carceller A., Domken V., Ramos F., Dobrescu O., Simard M. et al. Physical and neurodevelopmental evaluation of children adopted from Eastern Europe. Can. J. Clin. Pharmacol. 2009; 16(3):e432-40.
  28. Skagerstrуm J., Chang G., Nilsen P. Predictors of drinking during pregnancy: a systematic review. J. Womens Health. 2011; 20(6): 901-13.https://dx.doi.org/10.1089/jwh.2010.2216.
  29. Марянян А.Ю., Калькова А.Н., Акудович Н.В. Влияние алкоголя на био­элементный статус беременных женщин, употребляющих алкоголь в пренатальном периоде. Акушерство и гинекология. 2021; 10: 21-30. [Marianian A.Yu., Kalkova A.N., Akudovich N.V. Influence of alcohol consumption on the bioelement status of pregnant women in the prenatal period. Obstetrics and Gynecology. 2021; (10): 21-30. (in Russian)].https://dx.doi.org/10.18565/aig.2021.10.21-30.
  30. Беленичев И.Ф., Соколик Е.П., Егоров А.Н. Фармакологическая модуляция компенсаторных механизмов энергетического метаболизма в головном мозге пренатально алкоголизированных животных. Вестник новых медицинских технологий. 2014; 3: 16. [Belenichev I.F., Sokolik E.P., Egorov A.N. Pharmacological modulation of compensatory mechanisms of energy metabolism in the brain of prenatally alcoholic animals. Bulletin of New Medical Technologies. 2014; (3): 16. (in Russian)].
  31. Darenskaya M.A., Kolesnikov S.I., Rychkova L.R., Grebenkina L.A., Kolesnikova L.I. Oxidative stress and antioxidant defense parameters in different diseases: ethnic aspects. Free Radic. Biol. Med. 2018; 120(Suppl. 1): S60.
  32. Колесникова Л.И., Даренская М.А., Колесников С.И. Свободнорадикальное окисление: взгляд патофизиолога. Бюллетень сибирской медицины. 2017; 16(4): 16-29. [Kolesnikova L.I., Darenskaya M.A., Kolesnikov S.I. Free radical oxidation: A view of a pathophysiologist. Bulletin of Siberian Medicine. 2017; 16(4): 16-29. (in Rus-sian)]. https://dx.doi.org/10.20538/1682-0363-2017-4-16-29.
  33. Marianian A., Atalyan A., Bohora S., Darenskaya M., Grebenkina L., Kolesnikova L. et al. The effect of low alcohol consumption during pregnancy on the lipid peroxidation-antioxidant defense system of women, their alcohol-exposed infants, and growth, health, and developmental outcomes. Birth Defects Res. 2019; 112(1): 40-53. https://dx.doi.org/10.1002/bdr2.1582.
  34. Subramoney S., Eastman E., Adnams C., Stein D.J., Donald K.A. The early developmental outcomes of prenatal alcohol exposure: a review. Front. Neurol. 2018; 9: 1108. https://dx.doi.org/10.3389/fneur.2018.01108.
  35. Garrison L., Morley S., Chambers C.D., Bakhireva L.N. Forty Years of Assessing Neurodevelopmental and Behavioral Effects of Prenatal Alcohol Exposure in Infants: What Have We Learned? Alcohol. Clin. Exp. Res. 2019; 43(8): 1632-42. https://dx.doi.org/10.1111/acer.14127.
  36. Колпаков Я.В., Ялтонская А.В., Ялтонский В.М., Абросимов И.Н. Методология диагностики фетального алкогольного спектра нарушений у детей младшего школьного возраста в России. Вопросы наркологии. 2017; 4-5: 153-163. [Kolpakov Ya.V., Yaltonskaya A.V., Yaltonsky V.M., Abrosimov I.N. Methodology for diagnosing fetal alcohol spectrum disorders in children of primary school age in Russia. Questions of Narcology. 2017; 4-5: 153-63. (in Russian)].
  37. Hoyme H.E., Kalberg W.O., Elliott A.J., Blankenship J., Buckley D., Marais A.S. et al. Updated clinical guidelines for diagnosing fetal alcohol spectrum disorders. Pediatrics. 2016; 138(2): e20154256. https://dx.doi.org/10.1542/peds.2015-4256.
  38. Uban K.A., Kan E., Wozniak J.R., Mattson S.N., Coles C.D., Sowell E.R. The relationship between socioeconomic status and brain volume in children and adolescents with prenatal alcohol exposure. Front. Hum. Neurosci. 2020; 14: 85. https://dx.doi.org/10.3389/fnhum.2020.00085.
  39. Subramoney S., Joshi S.H., Wedderburn C.J., Lee D., Roos A., Woods R.P. et al. The impact of prenatal alcohol exposure on gray matter volume and cortical surface area of 2 to 3-year-old children in a South African birth cohort. Alcohol. Clin. Exp. Res. 2022; 46(7): 1233-47. https://dx.doi.org/10.1111/acer.14873.
  40. Poth L.D., Love T., Mattson S.N. Profiles of language and communication abilities in adolescents with fetal alcohol spectrum disorders. J. Int. Neuropsychol. Soc. 2022; Nov.3: 1-10. https://dx.doi.org/10.1017/S1355617722000789.
  41. Gautam P., Lebel C., Narr K.L., Mattson S.N., May P.A., Adnams C.M. et al. Volume changes and brain-behavior relationships in white matter and subcortical gray matter in children with prenatal alcohol exposure. Hum. Brain Mapp. 2015; 36(6): 2318-29. https://dx.doi.org/10.1002/hbm.22772.
  42. Bariselli S., Lovinger D.M. Corticostriatal circuit models of cognitive impairments induced by fetal exposure to alcohol. Biol. Psychiatry. 2021; 90(8): 516-28. https://dx.doi.org/10.1016/j.biopsych.2021.05.014.
  43. Gil-Mohapel J., Boehme F., Patten A., Cox A., Kainer L., Giles E. et al. Altered adult hippocampal neuronal maturation in a rat model of fetal alcohol syndrome. Brain Res. 2011; 1384: 29-41. https://dx.doi.org/10.1016/j.brainres.2011.01.116. 21.
  44. Delatour L.C., Pamela W.L. Yeh, Yeh H.H. Prenatal exposure to ethanol alters synaptic activity in layer V/VI pyramidal neurons of the somatosensory cortex. Cerebral Cortex. 2020; 30(3): 1735-51. https://dx.doi.org/10.1093/cercor/bhz199.
  45. Wozniak J.R., Mueller B.A., Muetzel R.L., Bell C.J., Hoecker H.L., Nelson M.L. et al. Inter-hemispheric functional connectivity disruption in children with prenatal alcohol exposure. Alcohol. Clin. Exp. Res. 2011; 35(5): 849-61.https://dx.doi.org/10.1111/j.1530-0277.2010.01415.x.
  46. Cook J.L., Green C.R., Lilley C.M., Anderson S.M., Baldwin M.E., Chudley A.E. Fetal alcohol spectrum disorder: Aguideline for diagnosis across the lifespan. CMAJ. 2016; 188(3): 191-7. https://dx.doi.org/10.1503/cmaj.141593.
  47. Фонд Организации Объединенных Наций в области народонаселения (ЮНФПА). Программа действий международной конфедерации по народонаселению и развитию. Принятая на Международной конференции по народонаселению и развитию. Каир, 5-13 сентября 1994 г. Доступно по: https://www.unfpa.org/sites/default/files/event-pdf/icpd_rus.pdf [United Nations Population Fund (UNFPA). Programme of Action of the International Conference on Population and Development. Adopted by the International Conference on Population and Development. Cairo, 5-13 September 1994. Available at: https://www.unfpa.org/sites/default/files/event-pdf/icpd_rus.pdf (in Russian)].
  48. Marianian A.Yu., Molchanova E.V. Social and economic effect of comprehensive prevention of fetal alcohol syndrome and fetal alcohol spectrum disorders in children: a review. J. Pharmaceutical Res. Int. 2020; 32(23): 115-23.https://dx.doi.org/10.9734/jpri/2020/v32i2330798.
  49. Burina E.A., Kulieva A.K., Marianian A.Y. The risk of fetal alcohol syndrome in pregnant women and women planning pregnancy. Alcoholism: Clin. Exp. Res. 2018; 42(6): 75. https://dx.doi.org/10.1111/acer.13833.
  50. Бурина Е.А., Марянян А.Ю. Психологические аспекты профилак-тики фетального алкогольного синдрома у беременных женщин репродуктивного возраста. Acta Biomedica Scientifica. 2018; 3(3):149-54. [Burina E.A., Marianian A.Yu. Psychological aspects of fetal alcohol syndrome prevention in pregnant women of childbearing age. Acta Biomedica Scientifica. 2018; 3(3): 149-54. (in Russian). https://dx.doi.org/10.29413/ABS.2018-3.3.23.
  51. Шилко В.И., Малахова Ж.Л., Бубнов А.А., Сергеева Л.М. Фетальный алкогольный спектр нарушений среди воспитанников домов ребенка. ВолГМУ. 2010; 4: 108-11. [Shilko V.I., Malakhova J.L., Bubnov A.A., Sergeeva L.M. Fetal alcohol syndrome in orphanage children. VolGMU. 2010; (4): 108-11. (in Russian)].

Received 18.11.2022

Accepted 27.04.2023

About the Authors

Anait Yu. Marianian, Dr. Med. Sci., Head of the Laboratory of Socially Important Problems of Reproductology, Leading Researcher, Scientific Center of Family Health Problems and Human Reproduction; Associate Professor at the Department of Obstetrics and Gynecology, ISMAPGE – Branch of the RMACPE, Ministry of Health of Russia, +7(3952)20-76-36, +7(914)014-70-65, anait_24@mail.ru, iphr@sbamsr.irk.ru, https://orcid.org/0000-0002-9544-2172, 664003, Russia, Irkutsk, Timiryazev str., 16.
Anastasia O. Anisimova, clinical intern and laboratory researcher at the Laboratory of Socially Important Problems of Reproductology, Scientific Center of Family Health Problems and Human Reproduction, +7(950)126-98-60, mozolewaao@gmail.com, https://orcid.org/0000-0003-2067-4224, 664003, Russia, Irkutsk, Timiryazev str., 16.
Anastasia N. Kalkova, graduate student and research assistant at the Laboratory of Socially Important Problems of Reproductology, Scientific Center of Family Health Problems and Human Reproduction, +7(902)576-00-19, Kalkova_Nastya@mail.ru, https://orcid.org/0000-0002-7626-020X, 664003, Russia, Irkutsk, Timiryazev str., 16.
Maria A. Rashidova, PhD, Researcher at the Laboratory of Physiology and Pathology of the Endocrine System, Scientific Center of Family Health Problems and Human Reproduction, +7(3952)20-76-36, 20-73-67, rashidovama@mail.ru, https://orcid.org/0000-0003-4730-5154, 664003, Russia, Irkutsk, Timiryazev str., 16.
Lyubov V. Rychkova, Professor, Dr. Med. Sci., Corresponding Member of the Russian Academy of Sciences, Director, Scientific Center of Family Health Problems and
Human Reproduction, +7(3952)20-76-36, 20-73-67, iphr@sbamsr.irk.ru, https://orcid.org/0000-0002-0117-2563, 664003, Russia, Irkutsk, Timiryazev str., 16.
Artyom E. Muradyan, 6th year student of the Faculty of Pediatrics, Pirogov Russian National Research Medical University, Ministry of Health of Russia,
+7(495)434-05-43, +7(919)724-54-79, don.muradian@yandex, rsmu@rsmu.ru, https://orcid.org/0000-0001-5350-0453, 117997, Russia, Moscow, Ostrovityanova str., 1.
Corresponding author: Anastasia O. Anisimova, mozolewaao@gmail.com

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