Long-term consequences of the effect of alcohol on the fetus

DOI

https://dx.doi.org/10.18565/aig.2022.276

Marianian A.Yu., Anisimova A.O., Kalkova A.N., Rashidova M.A., Rychkova L.V., Muradyan A.E.
Scientific Center of Family Health Problems and Human Reproduction, Irkutsk, Russia

High alcohol consumption is a social problem in our country and the world. The paper analyzes Russian and foreign literary sources for studying fetal alcohol syndrome (FAS) and fetal alcohol spectrum disorders (FASDs). By now, there have been a certain amount of studies on female alcohol use during pregnancy. FAS is observed for 1000 live newborns. There is no standard accounting system for the diagnosis of FAS/FASDs in any country of the world. A historical reference is given regarding the nature of alcohol effect on the fetus; however, the problem of the effects of alcohol metabolites at the biochemical and molecular levels requires further investigation. The babies who were born with the signs of FAS are noted to have phenotypic changes in the cerebral cranium and viscerocranium, morphological changes in brain tissue, mental disorders, and behavioral, neurological disorders. To prevent the occurrence of FAS/FASDs in children, it is necessary to enhance the role of medical workers in educating young people about the risk factors of these diseases.
Conclusion: the dissemination of modern information and the transfer of knowledge to pregnant women and reproductive-aged women by physicians, psychologists, social pedagog-ists, and social workers about the irreparable harm of their alcohol use done to the child are extremely important to prevent FAS and FASDs.
It is necessary to fix the attention of the society on the problem of FAS, to popularize a healthy lifestyle, to foster the alcohol use culture, as the ubiquitous availability of alcoholic beverages and the lack of self-discipline lead to harmful consequences.

Authors' contributions: Marianian A.Yu., Rychkova L.V. – the concept and design of the investigation, editing and approving the publication; Anismova A.O., Rashidova M.A., Kalkova A.N., Muradyan A.E. – material collection and processing, literature search for Russian and international studies in the Russian and international databases; Anisimova A.O., Kalkova A.N., Muradyan A.E. – analyzing the data of the published studies, writing the text.
Conflicts of interest: The authors declare that there are no conflicts of interest.
Funding: The authors declare that there is no external financing to conduct the investigation and to publish the article.
For citation: Marianian A.Yu., Anisimova A.O., Kalkova A.N., Rashidova M.A., Rychkova L.V., Muradyan A.E. Long-term consequences of the effect of alcohol on the fetus.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2023; (6): 16-22 (in Russian)
https://dx.doi.org/10.18565/aig.2022.276

pregnancy

fetus

alcohol

fetal alcoholic syndrome

fetal alcohol spectrum disorders

Full text (in Russian)

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Received 18.11.2022

Accepted 27.04.2023

Anait Yu. Marianian, Dr. Med. Sci., Head of the Laboratory of Socially Important Problems of Reproductology, Leading Researcher, Scientific Center of Family Health Problems and Human Reproduction; Associate Professor at the Department of Obstetrics and Gynecology, ISMAPGE – Branch of the RMACPE, Ministry of Health of Russia, +7(3952)20-76-36, +7(914)014-70-65, anait_24@mail.ru, iphr@sbamsr.irk.ru, https://orcid.org/0000-0002-9544-2172, 664003, Russia, Irkutsk, Timiryazev str., 16.
Anastasia O. Anisimova, clinical intern and laboratory researcher at the Laboratory of Socially Important Problems of Reproductology, Scientific Center of Family Health Problems and Human Reproduction, +7(950)126-98-60, mozolewaao@gmail.com, https://orcid.org/0000-0003-2067-4224, 664003, Russia, Irkutsk, Timiryazev str., 16.
Anastasia N. Kalkova, graduate student and research assistant at the Laboratory of Socially Important Problems of Reproductology, Scientific Center of Family Health Problems and Human Reproduction, +7(902)576-00-19, Kalkova_Nastya@mail.ru, https://orcid.org/0000-0002-7626-020X, 664003, Russia, Irkutsk, Timiryazev str., 16.
Maria A. Rashidova, PhD, Researcher at the Laboratory of Physiology and Pathology of the Endocrine System, Scientific Center of Family Health Problems and Human Reproduction, +7(3952)20-76-36, 20-73-67, rashidovama@mail.ru, https://orcid.org/0000-0003-4730-5154, 664003, Russia, Irkutsk, Timiryazev str., 16.
Lyubov V. Rychkova, Professor, Dr. Med. Sci., Corresponding Member of the Russian Academy of Sciences, Director, Scientific Center of Family Health Problems and
Human Reproduction, +7(3952)20-76-36, 20-73-67, iphr@sbamsr.irk.ru, https://orcid.org/0000-0002-0117-2563, 664003, Russia, Irkutsk, Timiryazev str., 16.
Artyom E. Muradyan, 6th year student of the Faculty of Pediatrics, Pirogov Russian National Research Medical University, Ministry of Health of Russia,
+7(495)434-05-43, +7(919)724-54-79, don.muradian@yandex, rsmu@rsmu.ru, https://orcid.org/0000-0001-5350-0453, 117997, Russia, Moscow, Ostrovityanova str., 1.
Corresponding author: Anastasia O. Anisimova, mozolewaao@gmail.com

Long-term consequences of the effect of alcohol on the fetus

Marianian A.Yu., Anisimova A.O., Kalkova A.N., Rashidova M.A., Rychkova L.V., Muradyan A.E.

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